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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Cash flows from operating activities:      
Net income (loss) $ (22,862) $ 6,820 $ 211,388
Adjustments to reconcile net income to net cash provided by operating activities:      
Stock-based compensation 27,403 21,013 15,096
Depreciation 13,275 12,965 12,379
Amortization of intangible assets 41,962 37,138 25,074
Non-cash interest expense and amortization of convertible debt issuance costs 7,578 6,749 6,372
Loss on extinguishment of debt 1,082 0 0
Impairment of in-process research and development intangible asset 0 18,300 0
Change in contingent consideration liability 0 (6,845) 0
Deferred tax (benefit) provision 39,535 (7,116) (172,706)
Excess Tax Benefit from Share-based Compensation, Operating Activities 0 (1,196) (747)
Non-cash restructuring 0 0 583
Gain from sale of intellectual property and property, plant and equipment, net 227 0 (3,670)
Effect of Exchange Rate on assumed cash liability from acquisition 0 (1,558) 0
Change in operating assets and liabilities, net of effects of acquisitions:      
Accounts receivable (1,110) 5,797 (10,407)
Prepaids and other assets 4,354 (6,205) (1,042)
Inventories 473 1,748 (3,412)
Accounts payable (651) 2,373 (2,621)
Accrued salaries and benefits and other accrued liabilities 5,564 (1,694) (2,150)
Deferred revenue 607 7,313 3,107
Net cash provided by operating activities 117,437 95,602 77,244
Cash flows from investing activities:      
Purchases of property, plant and equipment (9,385) (8,556) (6,132)
Payments to Acquire Intangible Assets 120 0 0
Purchases of marketable securities (102,497) (54,869) (157,811)
Maturities of marketable securities 32,048 110,081 112,721
Proceeds from sale of marketable securities 4,450 50,546 48,380
Proceeds from sale of intellectual property and property, plant and equipment, net 33 113 3,933
Acquisition of businesses, net of cash acquired 0 202,523 0
Net cash provided by (used in) investing activities (75,471) (105,208) 1,091
Cash flows from financing activities:      
Proceeds from Issuance of Senior Long-term Debt 172,500 0 0
Payments of Debt Issuance Costs (3,277) 0 0
Payments for Hedge, Financing Activities (33,523) 0 0
Proceeds from Issuance of Warrants 23,173 0 0
Repayment of senior convertible notes (72,257) 0 0
Proceeds received from issuance of common stock under employee stock plans 15,826 15,436 13,783
Payments under installment payment arrangement 0 0 (1,717)
Principal payments against financing lease obligation (860) (661) (478)
Payment of additional purchase consideration from acquisition 0 10,206 0
Repurchase and retirement of common stock, including prepayment under accelerated share repurchase program (50,038) 0 (100,113)
Incremental tax benefits from stock-based compensation 0 1,196 747
Payments Related to Tax Withholding for Share-based Compensation (5,099) (3,064) (802)
Net cash provided by (used in) financing activities 46,445 2,701 (88,580)
Effect of exchange rate changes on cash and cash equivalents 2,139 (1,565) (117)
Net increase (decrease) in cash and cash equivalents 90,550 (8,470) (10,362)
Cash and cash equivalents at beginning of year 135,294 143,764 154,126
Cash and cash equivalents at end of year 225,844 135,294 143,764
Cash paid during the period for:      
Interest 1,553 1,553 1,553
Income taxes, net of refunds 22,733 26,787 21,679
Non-cash investing and financing activities:      
Re-measurement of investment upon initial public offering 0 0 1,264
Property, plant and equipment received and accrued in accounts payable and other accrued liabilities $ 1,092 $ 576 $ 240