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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
3 Months Ended
Mar. 31, 2018
Mar. 31, 2017
Revenue:    
Royalties $ 21,374 $ 68,956
Product revenue 7,313 10,904
Contract and other revenue 17,739 17,491
Total revenue 46,426 97,351
Operating costs and expenses:    
Cost of product revenue [1] 4,357 5,250
Cost of contract and other revenue 12,122 14,481
Research and development [1] 40,117 36,000
Sales, general and administrative [1] 30,198 28,186
Restructuring Charges 3,245 0
Total operating costs and expenses 90,039 83,917
Operating income (loss) (43,613) 13,434
Interest income and other income (expense), net 9,116 154
Interest expense (4,421) (3,206)
Interest and other income (expense), net 4,695 (3,052)
Income (loss) before income taxes (38,918) 10,382
Provision for (benefit from) income taxes (3,229) 7,376
Net Income (Loss) $ (35,689) $ 3,006
Net income (loss) per share:    
Earnings Per Share, Basic $ (0.33) $ 0.03
Earnings Per Share, Diluted $ (0.33) $ 0.03
Weighted average shares used in per share calculation:    
Basic (in shares) 109,358 111,464
Diluted (in shares) 109,358 115,325
[1] Includes stock-based compensation