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CONSOLIDATED STATEMENTS OF OPERATIONS (Parenthetical) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Cost of product revenue |  |  |
Stock-based compensation | $ 8 | $ 78 | $ 56
Research and development |  |  |
Stock-based compensation | 12,582 | 12,185 | 9,165
Sales, general and administrative |  |  |
Stock-based compensation | $ 9,146 | $ 15,140 | $ 11,792

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