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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands

3 Months Ended

6 Months Ended

Jun. 30, 2019

Jun. 30, 2018

Jun. 30, 2019

Jun. 30, 2018

Revenues [Abstract]

Contract and other revenue

$ 58,297

$ 56,458

$ 106,681

$ 102,884

Operating costs and expenses:

Cost of Goods and Services Sold

^[1]

6,310

4,199

10,737

8,556

Cost of contract and other revenue

6,717

11,089

13,488

23,211

Research and development

^[1]

37,890

37,696

78,509

77,813

Sales, general and administrative

^[1]

24,908

24,483

52,553

54,681

Restructuring charges (recoveries)

2,528

(1,022)

2,859

2,223

Impairment of Long-Lived Assets to be Disposed of

16,990

0

16,990

0

Total operating costs and expenses

95,343

76,445

175,136

166,484

Operating income (loss)

(37,046)

(19,987)

(68,455)

(63,600)

Interest income and other income (expense), net

6,972

8,249

14,385

17,365

Interest expense

(2,534)

(4,634)

(4,805)

(9,055)

Interest and other income (expense), net

4,438

3,615

9,580

8,310

Loss before income taxes

(32,608)

(16,372)

(58,875)

(55,290)

Provision for (benefit from) income taxes

4,372

(1,015)

4,681

(4,244)

Net Income (Loss)

$ (36,980)

$ (15,357)

$ (63,556)

$ (51,046)

Net loss per share:

Earnings Per Share, Basic

$ (0.33)

$ (0.14)

$ (0.58)

$ (0.47)

Earnings Per Share, Diluted

$ (0.33)

$ (0.14)

$ (0.58)

$ (0.47)

Weighted average shares used in per share calculation:

Basic (in shares)

110,875

107,737

110,287

108,542

Diluted (in shares)

110,875

107,737

110,287

108,542

Royalty [Member]

Revenues [Abstract]

Contract and other revenue

$ 27,050

$ 30,049

$ 51,903

$ 51,423

Product Revenue [Member]

Revenues [Abstract]

Contract and other revenue

16,031

8,087

24,995

15,400

Contract and other Revenue [Member]

Revenues [Abstract]

Contract and other revenue

$ 15,216

$ 18,322

$ 29,783

$ 36,061

[1]

Includes stock-based compensation:

Cost of product revenue	$	1			$	2			$	2			$	5
Research and development	$	3,058			$	3,286			$	6,268			$	6,478
Sales, general and administrative	$	4,021			$	(1,400	)		$	7,999			$	2,919

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Amount, including tax collected from customer, of revenue from satisfaction of performance obligation by transferring promised good or service to customer. Tax collected from customer is tax assessed by governmental authority that is both imposed on and concurrent with specific revenue-producing transaction, including, but not limited to, sales, use, value-added and excise.

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The aggregate total costs related to selling a firm's product and services, as well as all other general and administrative expenses. Direct selling expenses (for example, credit, warranty, and advertising) are expenses that can be directly linked to the sale of specific products. Indirect selling expenses are expenses that cannot be directly linked to the sale of specific products, for example telephone expenses, Internet, and postal charges. General and administrative expenses include salaries of non-sales personnel, rent, utilities, communication, etc.

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The average number of shares or units issued and outstanding that are used in calculating diluted EPS or earnings per unit (EPU), determined based on the timing of issuance of shares or units in the period.

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Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.

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