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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
Revenues [Abstract] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | $ 224,027 | $ 231,201 | $ 393,096
Operating costs and expenses: |  |  |  |
Cost of product revenue | [1] | 27,156 | 18,299 | 23,783
Cost of contract and other revenue |  | 24,219 | 35,402 | 55,364
Research and development | [1] | 156,815 | 158,339 | 149,135
Sales, general and administrative | [1] | 104,116 | 103,911 | 110,940
Restructuring charges |  | 8,821 | 2,217 | 0
Loss from divestiture |  | 7,439 | 0 | 0
Gain from sale of intellectual property |  | 0 | 0 | (533)
Total operating costs and expenses |  | 328,566 | 318,168 | 338,689
Operating income (loss) |  | (104,539) | (86,967) | 54,407
Interest income (expense), net |  | 27,375 | 32,621 | 1,384
Loss on extinguishment of debt |  | 0 | 0 | (1,082)
Interest expense |  | (9,852) | (16,282) | (13,720)
Interest and other income (expense), net |  | 17,523 | 16,339 | (13,418)
Income (loss) before income taxes |  | (87,016) | (70,628) | 40,989
Provision for income taxes |  | 3,403 | 87,329 | 63,851
Net loss |  | $ (90,419) | $ (157,957) | $ (22,862)
Net loss per share: |  |  |  |
Basic (in dollars per share) |  | $ (0.81) | $ (1.46) | $ (0.21)
Diluted (in dollars per share) |  | $ (0.81) | $ (1.46) | $ (0.21)
Weighted average shares used in per share calculations: |  |  |  |
Basic (in shares) |  | 110,948 | 108,450 | 110,198
Diluted (in shares) |  | 110,948 | 108,450 | 110,198
Royalty [Member] |  |  |  |
Revenues [Abstract] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | $ 90,785 | $ 130,452 | $ 289,594
Product Revenue [Member] |  |  |  |
Revenues [Abstract] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | 72,972 | 38,690 | 36,509
Contract and other Revenue [Member] |  |  |  |
Revenues [Abstract] |  |  |  |
Revenue from Contract with Customer, Including Assessed Tax |  | $ 60,270 | $ 62,059 | $ 66,993
[1] |
* Includes stock-based compensation: |  |  |  |  |
Cost of product revenue | $ | 4 |  |  | $ | 8 |  |  | $ | 78 |
Research and development | $ | 11,032 |  |  | $ | 12,582 |  |  | $ | 12,185 |
Sales, general and administrative | $ | 15,440 |  |  | $ | 9,146 |  |  | $ | 15,140 |

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