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CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands

12 Months Ended

Dec. 31, 2019

Dec. 31, 2018

Dec. 31, 2017

Revenues [Abstract]

Revenue from Contract with Customer, Including Assessed Tax

$ 224,027

$ 231,201

$ 393,096

Operating costs and expenses:

Cost of product revenue

^[1]

27,156

18,299

23,783

Cost of contract and other revenue

24,219

35,402

55,364

Research and development

^[1]

156,815

158,339

149,135

Sales, general and administrative

^[1]

104,116

103,911

110,940

Restructuring charges

8,821

2,217

0

Loss from divestiture

7,439

0

0

Gain from sale of intellectual property

0

0

(533)

Total operating costs and expenses

328,566

318,168

338,689

Operating income (loss)

(104,539)

(86,967)

54,407

Interest income (expense), net

27,375

32,621

1,384

Loss on extinguishment of debt

0

0

(1,082)

Interest expense

(9,852)

(16,282)

(13,720)

Interest and other income (expense), net

17,523

16,339

(13,418)

Income (loss) before income taxes

(87,016)

(70,628)

40,989

Provision for income taxes

3,403

87,329

63,851

Net loss

$ (90,419)

$ (157,957)

$ (22,862)

Net loss per share:

Basic (in dollars per share)

$ (0.81)

$ (1.46)

$ (0.21)

Diluted (in dollars per share)

$ (0.81)

$ (1.46)

$ (0.21)

Weighted average shares used in per share calculations:

Basic (in shares)

110,948

108,450

110,198

Diluted (in shares)

110,948

108,450

110,198

Royalty [Member]

Revenues [Abstract]

Revenue from Contract with Customer, Including Assessed Tax

$ 90,785

$ 130,452

$ 289,594

Product Revenue [Member]

Revenues [Abstract]

Revenue from Contract with Customer, Including Assessed Tax

72,972

38,690

36,509

Contract and other Revenue [Member]

Revenues [Abstract]

Revenue from Contract with Customer, Including Assessed Tax

$ 60,270

$ 62,059

$ 66,993

[1]

* Includes stock-based compensation:
Cost of product revenue	$	4			$	8			$	78
Research and development	$	11,032			$	12,582			$	12,185
Sales, general and administrative	$	15,440			$	9,146			$	15,140

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- Definition

Number of [basic] shares or units, after adjustment for contingently issuable shares or units and other shares or units not deemed outstanding, determined by relating the portion of time within a reporting period that common shares or units have been outstanding to the total time in that period.

+ References

Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 45
-Paragraph 10
-URI http://asc.fasb.org/extlink&oid=109260490&loc=d3e1448-109256

Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 260
-SubTopic 10
-Section 50
-Paragraph 1
-Subparagraph (a)
-URI http://asc.fasb.org/extlink&oid=6371337&loc=d3e3550-109257

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