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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2020
Mar. 31, 2019
Revenue    
Revenue $ 63,989 $ 48,384
Cost of revenue    
Cost of product revenue [1] 10,343 4,427
Cost of contract and other revenue 1,198 2,908
Amortization of acquired intangible assets 4,344 3,863
Cost of revenue 15,885 11,198
Gross profit 48,104 37,186
Operating expenses:    
Research and development [1] 36,664 40,619
Sales, general and administrative [1] 22,895 26,520
Amortization of acquired intangible assets 348 1,125
Restructuring charges 836 331
Change in fair value of earn-out liability (1,800) 0
Total operating expenses 58,943 68,595
Operating loss (10,839) (31,409)
Interest income and other income (expense), net 6,374 7,413
Interest expense (2,555) (2,271)
Interest and other income (expense), net 3,819 5,142
Loss before income taxes (7,020) (26,267)
Provision for income taxes 963 309
Net loss $ (7,983) $ (26,576)
Net loss per share:    
Earnings per share, basic $ (0.07) $ (0.24)
Earnings per share, diluted $ (0.07) $ (0.24)
Weighted average shares used in per share calculation:    
Basic (in shares) 112,907 109,692
Diluted (in shares) 112,907 109,692
Royalties    
Revenue    
Revenue $ 19,694 $ 24,853
Product revenue    
Revenue    
Revenue 30,728 8,964
Contract and other revenue    
Revenue    
Revenue $ 13,567 $ 14,567
[1] Includes stock-based compensation:
Cost of product revenue
$
—

 
$
1

Research and development
$
2,613

 
$
3,210

Sales, general and administrative
$
3,459

 
$
3,978