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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Revenue        
Revenue $ 84,859 $ 61,717 $ 155,241 $ 127,494
Cost of revenue        
Cost of product revenue 11,422 10,277 22,832 20,620
Cost of contract and other revenue 1,017 1,535 2,573 2,733
Amortization of acquired intangible assets 4,439 4,336 8,825 8,680
Cost of revenue 16,878 16,148 34,230 32,033
Gross profit 67,981 45,569 121,011 95,461
Operating expenses:        
Research and development 31,469 34,688 63,823 71,352
Sales, general and administrative 22,184 21,721 45,746 45,027
Amortization of acquired intangible assets 229 248 458 596
Restructuring charges 0 0 368 836
Change in fair value of earn-out liability 0 0 0 (1,800)
Total operating expenses 53,882 56,657 110,395 116,011
Operating income (loss) 14,099 (11,088) 10,616 (20,550)
Interest income and other income (expense), net 2,381 4,688 5,362 11,131
Interest expense (2,683) (2,580) (5,297) (5,135)
Interest and other income (expense), net (302) 2,108 65 5,996
Income (loss) before income taxes 13,797 (8,980) 10,681 (14,554)
Provision for income taxes 2,631 160 2,128 1,125
Net income (loss) $ 11,166 $ (9,140) $ 8,553 $ (15,679)
Net income (loss) per share:        
Earnings per share, basic $ 0.10 $ (0.08) $ 0.08 $ (0.14)
Earnings per share, diluted $ 0.10 $ (0.08) $ 0.07 $ (0.14)
Weighted-average shares used in per share calculation:        
Basic (in shares) 112,144 113,572 112,177 113,240
Diluted (in shares) 114,931 113,572 115,358 113,240
Product revenue        
Revenue        
Revenue $ 31,170 $ 31,725 $ 61,951 $ 62,453
Royalties        
Revenue        
Revenue 41,910 18,744 70,769 40,226
Contract and other revenue        
Revenue        
Revenue $ 11,779 $ 11,248 $ 22,521 $ 24,815