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CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2022
Mar. 31, 2021
Revenue    
Revenue $ 99,050 $ 70,382
Cost of revenue    
Cost of product revenue 18,397 11,410
Cost of contract and other revenue 624 1,556
Amortization of acquired intangible assets 3,378 4,386
Cost of revenue 22,399 17,352
Gross profit 76,651 53,030
Operating expenses:    
Research and development 39,815 32,354
Sales, general and administrative 26,906 23,562
Amortization of acquired intangible assets 409 229
Restructuring charges 0 368
Change in fair value of earn-out liability 1,200 0
Total operating expenses 68,330 56,513
Operating income (loss) 8,321 (3,483)
Interest income and other income (expense), net 1,360 2,981
Loss on extinguishment of debt (66,497) 0
Loss on fair value adjustment of derivatives, net (8,283) 0
Interest expense (605) (2,614)
Interest and other income (expense), net (74,025) 367
Loss before income taxes (65,704) (3,116)
Provision for (benefit from) income taxes 514 (503)
Net loss $ (66,218) $ (2,613)
Net loss per share:    
Basic net loss per share $ (0.60) $ (0.02)
Diluted net loss per share $ (0.60) $ (0.02)
Weighted-average shares used in per share calculation:    
Basic (in shares) 109,889 112,211
Diluted (in shares) 109,889 112,211
Product revenue    
Revenue    
Revenue $ 47,969 $ 30,781
Royalties    
Revenue    
Revenue 30,464 28,859
Contract and other revenue    
Revenue    
Revenue $ 20,617 $ 10,742