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Equity Incentive Plans and Stock-Based Compensation (Details Narrative)
3 Months Ended 12 Months Ended
Apr. 30, 2020
shares
Sep. 30, 2019
shares
Dec. 31, 2022
USD ($)
plan
$ / shares
shares
Dec. 31, 2021
USD ($)
$ / shares
shares
Dec. 31, 2020
USD ($)
$ / shares
shares
Dec. 31, 2019
shares
Stock-Based Compensation            
Tenure of award     10 years      
Minimum            
Stock-Based Compensation            
Awards, vesting rights     0.00%      
Maximum            
Stock-Based Compensation            
Awards, vesting rights     200.00%      
Option One            
Stock-Based Compensation            
Requisite service period     60 months      
Option Two            
Stock-Based Compensation            
Requisite service period     48 months      
Stock compensation plan            
Stock-Based Compensation            
Number of additional shares authorized | shares [1]         7,800,000  
Shares available for issuance | shares     7,655,769 10,492,178 12,412,320 6,826,863
Options granted | shares         40,000  
Stock compensation plan | 2019 Inducement Equity Incentive Plan            
Stock-Based Compensation            
Number of additional shares authorized | shares   400,000        
Contingently issuable ESPP shares            
Stock-Based Compensation            
Number of additional shares authorized | shares 2,000,000          
Number of employee stock purchase plans | plan     1      
Minimum number of hours of weekly employment in order to qualify for eligibility in the plan     20 hours      
Minimum number of months of employment in a fiscal year in order to qualify for eligibility in the plan     5 months      
Offering period     6 months      
Percentage of the price at the beginning of the offering period or price at the end of each offering period to derive purchase price     85.00%      
Maximum share value per employee in any calendar year | $     $ 25,000      
Employee stock purchase plan, shares issued during period | shares     255,614 384,087 467,065  
Employee stock purchase plan, weighted-average price per share | $ / shares     $ 20.60 $ 12.95 $ 10.51  
Shares available for issuance | shares     2,600,000      
Stock-based compensation expense | $     $ 1,700,000 $ 1,400,000 $ 1,500,000  
Unrecognized compensation cost | $     $ 800,000      
Unrecognized compensation cost, weighted-average period     4 months      
Stock options            
Stock-Based Compensation            
Options granted | shares         40,000  
Stock-based compensation expense | $     $ 100,000 400,000 $ 600,000  
Unrecognized compensation cost | $     $ 100,000      
Unrecognized compensation cost, weighted-average period     9 months 18 days      
Total fair value of options vested | $     $ 1,700,000 $ 2,000,000 $ 3,300,000  
Nonvested equity stock and stock units            
Stock-Based Compensation            
Requisite service period     4 years 4 years 4 years  
Stock-based compensation expense | $     $ 33,800,000 $ 25,700,000 $ 23,700,000  
Unrecognized compensation cost | $     $ 63,500,000      
Unrecognized compensation cost, weighted-average period     2 years 1 month 6 days      
Awards, nonvested grants in period, shares | shares     2,338,255 2,363,885 1,986,117  
Awards, nonvested grants in period, fair value | $     $ 65,600,000 $ 50,100,000 $ 31,000,000  
Nonvested equity stock and stock units | Director            
Stock-Based Compensation            
Requisite service period     1 year 1 year 1 year  
[1] On April 30, 2020, the Company’s stockholders approved an additional 7,800,000 shares for issuance under the 2015 Plan.