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v3.7.0.1

Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2017 | Mar. 31, 2016
Statement of Cash Flows [Abstract] |  |  |
Net income (loss) | $ 16,700 |  | $ (59,223)
Adjustments to reconcile net income (loss) to net cash provided by operating activities: |  |  |
Depreciation and amortization | 281 |  | 229
Stock-based compensation expense | 4,713 |  | 11,185
Amortization of debt discounts and debt issuance costs | 89 |  | 3,161
Accrual of interest paid in kind | 2,068 |  | 1,936
Other | 680 |  | 440
Changes in assets and liabilities: |  |  |
Trade and other receivables | 6,541 |  | (4,956)
Inventory | 34 |  | 144
Prepaid expenses and other current assets | (881) |  | (985)
Other long-term assets | (19) |  | 241
Accounts payable | (1,916) |  | (744)
Accrued compensation and benefits | (5,844) |  | 2,413
Accrued clinical trial liabilities | 347 |  | (1,936)
Accrued collaboration liability | 0 |  | 3,736
Deferred revenue | 35,139 |  | 198,802
Other current and long-term liabilities | 10,926 |  | 2,367
Net cash provided by (used in) operating activities | 68,858 |  | 156,810
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (808) |  | (682)
Proceeds from sale of property and equipment | 4 |  | 107
Proceeds from maturities of restricted cash and investments | 3,504 |  | 2,004
Purchase of restricted cash and investments | (3,504) |  | (2,004)
Proceeds from sale of investments | 37,294 |  | 17
Proceeds from maturities of investments | 122,507 |  | 30,108
Purchases of investments | (124,494) |  | (49,235)
Net cash provided by (used in) investing activities | 34,503 |  | (19,685)
Cash flows from financing activities: |  |  |
Proceeds from exercise of stock options | 9,675 |  | 37
Taxes paid related to net share settlement of equity awards | (1,543) |  | (1,914)
Principal payments on debt | (80,000) |  | 0
Net cash used in financing activities | (71,868) |  | (1,877)
Net increase in cash and cash equivalents | 31,493 |  | 135,248
Cash and cash equivalents at beginning of year | 151,686 | [1] | 141,634
Cash and cash equivalents at end of year | $ 183,179 |  | $ 276,882
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited financial statements as of that date.

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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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