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Collaboration Agreements (Takeda Collaboration) (Details) - USD ($) | 1 Months Ended | 3 Months Ended |  |
--- | --- | --- | --- | ---
Feb. 28, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | [1] | Feb. 28, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Current portion of deferred revenue |  | $ 30,662,000 | $ 19,665,000 |
Long-term portion of deferred revenue |  | $ 261,236,000 | $ 237,094,000 |
Collaborative Arrangement with Ipsen [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Upfront payment |  |  |  | $ 200,000,000
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 35.00% |  |
Current portion of deferred revenue |  | $ 19,000,000 |  |
Long-term portion of deferred revenue |  | 224,400,000 |  |
Collaborative Arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Upfront payment | $ 50,000,000 |  |  |
Maximum amount eligible for development and regulatory milestones |  | 95,000,000 |  |
Maximum pre-specified payments |  | $ 83,000,000 |  |
Collaboration period to achieve specified levels of commercial performance | 6 years |  |  |
Deferred revenue, recognition period |  | 4 years |  |
Current portion of deferred revenue |  | $ 11,300,000 |  |
Long-term portion of deferred revenue |  | $ 36,800,000 |  |
Collaborative Arrangement with Takeda [Member] | Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Termination of collaboration agreement, period for written notice | 12 months |  |  |
Collaborative Arrangement with Takeda [Member] | Global [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 20.00% |  |
Collaborative Arrangement with Takeda [Member] | Japan [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 100.00% |  |
Final Tier [Member] | Collaborative Arrangement with Ipsen [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Cumulative net sales |  | $ 150,000,000 |  |
Final Tier [Member] | Collaborative Arrangement with Ipsen [Member] | Minimum [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 22.00% |  |
Final Tier [Member] | Collaborative Arrangement with Ipsen [Member] | Maximum [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 26.00% |  |
Final Tier [Member] | Collaborative Arrangement with Takeda [Member] | Minimum [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 20.00% |  |
Final Tier [Member] | Collaborative Arrangement with Takeda [Member] | Maximum [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 30.00% |  |
Initial [Member] | Collaborative Arrangement with Ipsen [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 2.00% |  |
Cumulative net sales |  | $ 50,000,000 |  |
Initial [Member] | Collaborative Arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Cumulative net sales |  | $ 300,000,000.0 |  |
Initial [Member] | Collaborative Arrangement with Takeda [Member] | Minimum [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 15.00% |  |
Initial [Member] | Collaborative Arrangement with Takeda [Member] | Maximum [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 24.00% |  |
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited financial statements as of that date.

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