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Collaboration Agreements (GlaxoSmithKline Collaboration) (Details) - USD ($) $ in Millions | 3 Months Ended
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Mar. 31, 2017 | Mar. 31, 2016
GlaxoSmithKline [Member] |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Royalty expense | $ 2.7 | $ 0.3

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- Definition Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table. + References No definition available. + Details
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Namespace Prefix: | us-gaap_
Data Type: | xbrli:stringItemType
Balance Type: | na
Period Type: | duration

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- Definition Amount of expense related to royalty payments under a contractual arrangement such as payment for mineral and drilling rights and use of technology or intellectual property. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 225 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.3) -URI http://asc.fasb.org/extlink&oid=63488584&loc=d3e20235-122688 + Details
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Namespace Prefix: | us-gaap_
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Balance Type: | debit
Period Type: | duration

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- Details
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Namespace Prefix: |
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Balance Type: |
Period Type: |