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Collaboration Agreements (Ipsen Collaboration) (Details)	3 Months Ended
	Mar. 31, 2017 USD ($)	Dec. 31, 2016 USD ($) milestone		Nov. 29, 2016 USD ($)	Feb. 28, 2016 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Current portion of deferred revenue	$ 30,662,000	$ 19,665,000	[1]
Long-term portion of deferred revenue	$ 261,236,000	237,094,000	[1]
GlaxoSmithKline [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale	3.00%
Collaborative Arrangement with Ipsen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment					$ 200,000,000
Non-substantive milestone payment				$ 60,000,000
Research and development arrangement performed for others, reimbursement for costs incurred, percent	35.00%
Reimbursements of certain clinical programs paid	$ 1,100,000
Current portion of deferred revenue	19,000,000
Long-term portion of deferred revenue	224,400,000
Collaborative Arrangement with Ipsen [Member] | Restatement Adjustment [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Deferred revenue reclassified	$ 9,000,000
Collaborative Arrangement with Ipsen [Member] | Initial [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale	2.00%
Royalty tier	$ 50,000,000
Collaborative Arrangement with Ipsen [Member] | Second [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale	12.00%
Royalty tier	$ 100,000,000
Collaborative Arrangement with Ipsen [Member] | Initial and Second [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty tier	$ 150,000,000
Collaborative Arrangement with Ipsen [Member] | Initial and Second [Member] | Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale	22.00%
Collaborative Arrangement with Ipsen [Member] | Initial and Second [Member] | Maximum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale	26.00%
Collaborative Arrangement with Ipsen [Member] | Canada [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment		$ 10,000,000
Collaborative Arrangement with Ipsen, First Commercial Sales of Product [Member] | CABOMETYX [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Number of milestones achieved | milestone		2
Collaborative Arrangement with Ipsen, First Commercial Sales of Product [Member] | Germany [Member] | CABOMETYX [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Revenue recognized, milestones		$ 10,000,000
[1] The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited financial statements as of that date.

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