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Collaboration Agreements (Takeda Collaboration) (Details) - USD ($)	1 Months Ended	3 Months Ended
	Feb. 28, 2017	Mar. 31, 2017	Dec. 31, 2016	[1]	Feb. 28, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Current portion of deferred revenue		$ 30,662,000	$ 19,665,000
Long-term portion of deferred revenue		$ 261,236,000	$ 237,094,000
Collaborative Arrangement with Ipsen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment					$ 200,000,000
Research and development arrangement performed for others, reimbursement for costs incurred, percent		35.00%
Current portion of deferred revenue		$ 19,000,000
Long-term portion of deferred revenue		224,400,000
Collaborative Arrangement with Takeda [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment	$ 50,000,000
Maximum amount eligible for development and regulatory milestones		95,000,000
Maximum pre-specified payments		$ 83,000,000
Collaboration period to achieve specified levels of commercial performance	6 years
Deferred revenue, recognition period		4 years
Current portion of deferred revenue		$ 11,300,000
Long-term portion of deferred revenue		$ 36,800,000
Collaborative Arrangement with Takeda [Member] | Takeda [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Termination of collaboration agreement, period for written notice	12 months
Collaborative Arrangement with Takeda [Member] | Global [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development arrangement performed for others, reimbursement for costs incurred, percent		20.00%
Collaborative Arrangement with Takeda [Member] | Japan [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Research and development arrangement performed for others, reimbursement for costs incurred, percent		100.00%
Final Tier [Member] | Collaborative Arrangement with Ipsen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Cumulative net sales		$ 150,000,000
Final Tier [Member] | Collaborative Arrangement with Ipsen [Member] | Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		22.00%
Final Tier [Member] | Collaborative Arrangement with Ipsen [Member] | Maximum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		26.00%
Final Tier [Member] | Collaborative Arrangement with Takeda [Member] | Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		20.00%
Final Tier [Member] | Collaborative Arrangement with Takeda [Member] | Maximum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		30.00%
Initial [Member] | Collaborative Arrangement with Ipsen [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		2.00%
Cumulative net sales		$ 50,000,000
Initial [Member] | Collaborative Arrangement with Takeda [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Cumulative net sales		$ 300,000,000.0
Initial [Member] | Collaborative Arrangement with Takeda [Member] | Minimum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		15.00%
Initial [Member] | Collaborative Arrangement with Takeda [Member] | Maximum [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale		24.00%
[1] The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited financial statements as of that date.

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