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Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Revenues:    
Net product revenues $ 68,877 $ 9,099
Collaboration revenues 12,010 6,328
Total revenues 80,887 15,427
Operating expenses:    
Cost of goods sold 3,203 685
Research and development 23,210 28,926
Selling, general and administrative 34,260 34,857
Restructuring charges 28 94
Total operating expenses 60,701 64,562
Income (loss) from operations 20,186 (49,135)
Other expense, net:    
Interest income and other, net 1,068 202
Interest expense (4,420) (10,290)
Total other expense, net (3,352) (10,088)
Income (loss) before income taxes 16,834 (59,223)
Income tax expense 134 0
Net income (loss) $ 16,700 $ (59,223)
Net income (loss) per share, basic (in dollars per share) $ 0.06 $ (0.26)
Net income (loss) per share, diluted (in dollars per share) $ 0.05 $ (0.26)
Shares used in computing net income (loss) per share, basic 290,870 228,304
Shares used in computing net income (loss) per share, diluted 309,535 228,304