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Debt (Deerfield Notes) (Details) - Secured Notes [Member] - Deerfield Notes [Member] - USD ($)
 3 Months Ended
Mar. 31, 2017
Dec. 31, 2016
Debt Instrument [Line Items]    
Aggregate principal amount $ 113,900,000 $ 109,800,000
Convertible debt $ 113,349,000 109,122,000
Interest rate after extension option election (as a percent) 15.00%  
Prepayment price (as a percent) 105.00%  
Balance of unamortized closing fees and expenses $ 400,000 $ 400,000
Effective interest rate (as a percent) 15.20%  
Percentage of revenues payable under collaborative arrangements (as a percent) 15.00%  
Maximum prepayment amount under collaborative arrangements $ 27,500,000.0  
Mandatory prepayments $ 8,200,000  
Coupon Interest [Member]    
Debt Instrument [Line Items]    
Interest rate after extension option election (as a percent) 7.50%  
Payment-in-Kind Interest [Member]    
Debt Instrument [Line Items]    
Interest rate after extension option election (as a percent) 7.50%