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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2017
Mar. 31, 2016
Statement of Cash Flows [Abstract]    
Net income (loss) $ 16,700 $ (59,223)
Adjustments to reconcile net income (loss) to net cash provided by operating activities:    
Depreciation and amortization 281 229
Stock-based compensation expense 4,713 11,185
Amortization of debt discounts and debt issuance costs 89 3,161
Accrual of interest paid in kind 2,068 1,936
Other 680 440
Changes in assets and liabilities:    
Trade and other receivables 6,541 (4,956)
Inventory 34 144
Prepaid expenses and other current assets (881) (985)
Other long-term assets (19) 241
Accounts payable (1,916) (744)
Accrued compensation and benefits (5,844) 2,413
Accrued clinical trial liabilities 347 (1,936)
Accrued collaboration liability 0 3,736
Deferred revenue 35,139 198,802
Other current and long-term liabilities 10,926 2,367
Net cash provided by (used in) operating activities 68,858 156,810
Cash flows from investing activities:    
Purchases of property and equipment (808) (682)
Proceeds from sale of property and equipment 4 107
Proceeds from maturities of restricted cash and investments 3,504 2,004
Purchase of restricted cash and investments (3,504) (2,004)
Proceeds from sale of investments 37,294 17
Proceeds from maturities of investments 122,507 30,108
Purchases of investments (124,494) (49,235)
Net cash provided by (used in) investing activities 34,503 (19,685)
Cash flows from financing activities:    
Proceeds from exercise of stock options 9,675 37
Taxes paid related to net share settlement of equity awards (1,543) (1,914)
Principal payments on debt (80,000) 0
Net cash used in financing activities (71,868) (1,877)
Net increase in cash and cash equivalents 31,493 135,248
Cash and cash equivalents at beginning of year 151,686 [1] 141,634
Cash and cash equivalents at end of year $ 183,179 $ 276,882
[1] The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited financial statements as of that date.