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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2017 | Jun. 30, 2016
Statement of Cash Flows [Abstract] |  |  |
Net income (loss) | $ 34,356 |  | $ (94,061)
Adjustments to reconcile net income (loss) to net cash provided by operating activities: |  |  |
Depreciation and amortization | 563 |  | 456
Stock-based compensation expense | 9,740 |  | 14,743
Loss on extinguishment of debt | 6,239 |  | 0
Amortization of debt discounts and debt issuance costs | 182 |  | 6,411
Accrual of interest paid in kind | (11,825) |  | 3,908
Gain on sale of other equity investments | (639) |  | 0
Other | 1,146 |  | 921
Changes in assets and liabilities: |  |  |
Trade and other receivables | (2,581) |  | (11,550)
Inventory | (2,087) |  | (192)
Prepaid expenses and other current assets | 1,049 |  | (851)
Other long-term assets | 519 |  | 99
Accounts payable | 472 |  | (966)
Accrued compensation and benefits | (4,779) |  | 6,678
Accrued clinical trial liabilities | 549 |  | (2,390)
Accrued collaboration liabilities | 5,873 |  | 6,055
Deferred revenue | 28,159 |  | 195,469
Other current and long-term liabilities | 7,457 |  | 6,346
Net cash provided by (used in) operating activities | 74,393 |  | 131,076
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (2,312) |  | (1,083)
Proceeds from sale of property and equipment | 14 |  | 112
Proceeds from sale of other equity investments | 639 |  | 0
Proceeds from maturities of restricted cash and investments | 5,650 |  | 2,650
Purchase of restricted cash and investments | (6,150) |  | (4,150)
Proceeds from sale of investments | 37,294 |  | 17
Proceeds from maturities of investments | 200,893 |  | 58,340
Purchases of investments | (154,809) |  | (199,396)
Net cash provided by (used in) investing activities | 81,219 |  | (143,510)
Cash flows from financing activities: |  |  |
Proceeds from exercise of stock options | 12,980 |  | 2,207
Proceeds from employee stock purchase plan | 3,053 |  | 479
Taxes paid related to net share settlement of equity awards | (2,331) |  | (2,059)
Repayment of convertible notes and term loan payable | (185,788) |  | 0
Net cash (used in) provided by financing activities | (172,086) |  | 627
Net decrease in cash and cash equivalents | (16,474) |  | (11,807)
Cash and cash equivalents at beginning of year | 151,686 | [1] | 141,634
Cash and cash equivalents at end of year | 135,212 |  | 129,827
Supplemental cash flow disclosure - non-cash investing and financing activity: |  |  |
Construction-in-progress deemed to have been acquired under build-to-suit lease | $ 14,530 |  | $ 0
[1] | The condensed consolidated balance sheet as of December 31, 2016 has been derived from the audited financial statements as of that date.

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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the sale and maturity (principal being due) of other investments, prepayment and call (request of early payment) of other investments not otherwise defined in the taxonomy. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=66010992&loc=d3e26853-111562 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Investing Activities -URI http://asc.fasb.org/extlink&oid=6516133 + Details
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- Definition The cash inflow associated with the amount received from holders exercising their stock options. This item inherently excludes any excess tax benefit, which the entity may have realized and reported separately. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (j) -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3291-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Financing Activities -URI http://asc.fasb.org/extlink&oid=6513228 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66902209&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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