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Concentrations of Credit Risk (Tables)
 6 Months Ended
Jun. 30, 2017
Risks and Uncertainties [Abstract]  
Schedules of Concentration Risk
The following table shows the revenues earned by geographic region. Net product revenues are attributed to regions based on the delivery location. Collaboration revenues are attributed to regions based on the location of our collaboration partner's headquarters (dollars in thousands):
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2017
 
2016
 
2017
 
2016
U.S.
$
89,371

 
$
32,192

 
$
163,046

 
$
45,786

Europe
5,494

 
4,060

 
10,024

 
5,893

Japan
4,143

 
—

 
6,825

 
—

The percentage of total revenues recognized by customer that represent 10% or more of total revenues was as follows:
 
Three Months Ended June 30,
 
Six Months Ended June 30,
 
2017
 
2016
 
2017
 
2016
Diplomat Specialty Pharmacy
23
%
 
52
%
 
24
%
 
53
%
Caremark L.L.C.
19
%
 
9
%
 
18
%
 
6
%
Accredo Health, Incorporated
14
%
 
7
%
 
13
%
 
5
%
Affiliates of McKesson Corporation
13
%
 
6
%
 
13
%
 
4
%
Merck
—
%
 
—
%
 
—
%
 
10
%