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Collaboration Agreements (Collaboration Revenues - Ipsen) (Details) - USD ($)
$ in Thousands
 3 Months Ended 6 Months Ended
Jun. 30, 2017
Jun. 30, 2016
Jun. 30, 2017
Jun. 30, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Product supply agreement revenue $ 88,004 $ 31,618 $ 156,881 $ 40,717
Cost of supplied product (3,014) (1,560) (6,217) (2,245)
Collaboration revenues under the collaboration agreement 11,004 4,634 23,014 10,962
Collaborative Arrangement with Ipsen [Member]        
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]        
Amortization of upfront payments and deferred milestone 4,741 3,592 9,046 4,790
Royalty revenue 219 0 443 0
Development cost reimbursements 862 0 1,199 0
Product supply agreement revenue 811 0 1,802 0
Cost of supplied product (811) 0 (1,802) 0
Royalty payable to GSK on net sales by Ipsen (328) 0 (664) 0
Collaboration revenues under the collaboration agreement $ 5,494 $ 3,592 $ 10,024 $ 4,790