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Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 29, 2017 | Dec. 30, 2016 | Jan. 01, 2016
Cash flows from operating activities: |  |  |
Net income (loss) | $ 154,227 | $ (70,222) | $ (161,744)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |
Depreciation and amortization | 1,187 | 1,002 | 1,406
Stock-based compensation | 23,938 | 22,912 | 21,977
Loss on extinguishment of debt | 6,239 | 13,901 | 0
Amortization of debt discounts and debt issuance costs | 182 | 8,432 | 17,041
Interest paid in kind | (11,825) | 8,008 | 3,817
Gain on other equity investments | (2,980) | (2,494) | (112)
Changes in warrant fair value | 0 | 0 | 548
Other | 1,589 | 1,598 | 1,861
Changes in assets and liabilities: |  |  |
Trade and other receivables | (40,839) | (35,318) | (540)
Inventory, net | (3,319) | (722) | (235)
Prepaid expenses and other current assets | (3,268) | (1,610) | (325)
Other long-term assets | 430 | 1,077 | 1,340
Accounts payable | 3,010 | 164 | (12)
Accrued compensation and benefits | 739 | 16,705 | 279
Accrued clinical trial liabilities | 5,718 | (3,940) | (23,474)
Accrued collaboration liabilities | 6,928 | (10,938) | 10,206
Deferred revenue | 13,745 | 256,759 | (2,582)
Other current and long-term liabilities | 9,910 | 5,090 | (10,502)
Net cash used in operating activities | 165,611 | 210,404 | (141,051)
Cash flows from investing activities: |  |  |
Purchases of property and equipment | (21,143) | (1,703) | (447)
Proceeds from sale of property and equipment | 164 | 97 | 1,346
Purchases of investments | (319,090) | (369,187) | (143,992)
Proceeds from maturities of investments | 336,590 | 151,485 | 178,936
Proceeds from sale of investments | 37,294 | 2,266 | 0
Purchase of restricted cash and investments | (15,650) | (8,650) | (5,650)
Proceeds from maturities of restricted cash and investments | 14,650 | 7,150 | 19,789
Proceeds from other equity investments | 2,980 | 2,494 | 95
Net cash (used in) provided by investing activities | 35,795 | (216,048) | 50,077
Cash flows from financing activities: |  |  |
Principal repayments of debt | (185,788) | (575) | (4,381)
Payments on conversion of convertible notes | 0 | (7,135) | 0
Proceeds from issuance of common stock, net | 0 | 0 | 145,649
Proceeds from exercise of stock options | 17,555 | 25,327 | 10,911
Proceeds from employee stock purchase plan | 4,868 | 2,187 | 568
Taxes paid related to net share settlement of equity awards | (6,563) | (4,108) | (534)
Net cash provided by financing activities | (169,928) | 15,696 | 152,213
Net increase (decrease) in cash and cash equivalents | 31,478 | 10,052 | 61,239
Cash and cash equivalents at beginning of year | 151,686 | 141,634 | 80,395
Cash and cash equivalents at end of year | 183,164 | 151,686 | 141,634
Supplemental cash flow disclosure: |  |  |
Cash paid for interest | 20,460 | 21,044 | 19,822
Cash paid for taxes | 538 | 190 | 192
Non-cash investing and financing activity: |  |  |
Construction in progress deemed to have been acquired under build-to-suit lease | 14,530 | 0 | 0
Issuance of common stock in settlement of convertible notes | $ 0 | $ 286,925 | $ 0

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- Definition Amount of cash outflow to satisfy an employee's income tax withholding obligation as part of a net-share settlement of a share-based award. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 25 -Paragraph 19A -URI http://asc.fasb.org/extlink&oid=96949009&loc=SL79513924-113897 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition The cash outflow to acquire debt securities classified as available-for-sale securities, because they are not classified as either held-to-maturity securities or trading securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash outflow to acquire investments (not to include restricted cash) that are pledged or subject to withdrawal restrictions. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash inflow associated with maturities (principal being due), prepayments and calls (requests of early payments) on securities not classified as either held-to-maturity securities or trading securities which are classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 + Details
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- Definition The cash inflow associated with the sale and maturity (principal being due) of other investments, prepayment and call (request of early payment) of other investments not otherwise defined in the taxonomy. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the sale of debt and equity securities classified as available-for-sale securities. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition Amount of cash inflow from exercise of stock options granted under share-based compensation arrangement. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=96867065&loc=SL79508275-113901 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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- References No definition available. + Details
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