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Collaboration Agreements (Takeda Collaboration, Narrative) (Details) - USD ($) | 1 Months Ended | 12 Months Ended
--- | --- | ---
Feb. 28, 2017 | Dec. 29, 2017 | Dec. 30, 2016 | Jan. 01, 2016
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Collaboration revenues |  | $ 103,469,000 | $ 56,079,000 | $ 3,014,000
Current portion of deferred revenue |  | 31,984,000 | 19,665,000 |
Long-term portion of deferred revenue |  | $ 238,520,000 | 237,094,000 |
Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Upfront and milestone payments | $ 50,000,000 |  |  |
Deferred revenue, recognition period |  | 4 years |  |
Maximum amount eligible for development and regulatory milestones |  | $ 95,000,000 |  |
Maximum amount eligible for commercial milestones under collaborations agreement |  | 83,000,000 |  |
Collaboration revenues |  | 14,779,000 | $ 0 | $ 0
Current portion of deferred revenue |  | 11,300,000 |  |
Long-term portion of deferred revenue |  | $ 28,300,000 |  |
Period for specific commercial performance |  | 6 years |  |
Initial [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Royalty tier |  | $ 300,000,000.0 |  |
Initial [Member] | Minimum [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 15.00% |  |
Initial [Member] | Maximum [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 24.00% |  |
Final tier [Member] | Minimum [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 20.00% |  |
Final tier [Member] | Maximum [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Percent of royalty on net sale |  | 30.00% |  |
Global [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 20.00% |  |
Japan [Member] | Collaborative arrangement with Takeda [Member] |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 100.00% |  |
Collaboration period to achieve specified levels of commercial performance |  | 2 years |  |

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