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Organization and Summary of Significant Accounting Policies (Narrative) (Details)
1 Months Ended 12 Months Ended
Nov. 30, 2015
Oct. 31, 2008
Dec. 29, 2017
USD ($)
segment
product
Dec. 30, 2016
USD ($)
Jan. 01, 2016
USD ($)
Organization And Summary Of Significant Policies [Line Items]          
Number of products that entered in the commercial marketplace | product     3    
Number of reportable segments | segment     1    
Impairment charge on goodwill     $ 0 $ 0 $ 0
Percent discount for prompt payment     2.00%    
Discount expected to be earned     100.00%    
Adoption of Accounting Standards Update No. 2016-09       0  
Net cash provided by operating activities     $ 165,611,000 210,404,000 (141,051,000)
Net cash used in financing activities     169,928,000 (15,696,000) (152,213,000)
Accumulated deficit     $ 1,829,172,000 1,983,147,000  
GlaxoSmithKline [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Percent of royalty on net sale   3.00%      
Collaborative Arrangement with Genentech [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Percentage of share of the Company in promotions 25.00%        
Collaborative Arrangement with Genentech [Member] | Maximum [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Percentage of share of the Company in promotions     25.00%    
Products Derived from Cabozantinib [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Number of products that entered in the commercial marketplace | product     2    
Accounting Standards Update 2016-09 [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Net cash provided by operating activities       4,100,000 500,000
Net cash used in financing activities       4,100,000 $ 500,000
Accumulated Deficit [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Adoption of Accounting Standards Update No. 2016-09       252,000  
Accumulated Deficit [Member] | Accounting Standards Update 2016-09 [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Adoption of Accounting Standards Update No. 2016-09       300,000  
Additional Paid-In Capital [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Adoption of Accounting Standards Update No. 2016-09       $ (252,000)  
Additional Paid-In Capital [Member] | Accounting Standards Update 2016-09 [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Adoption of Accounting Standards Update No. 2016-09     $ (300,000)    
Difference between Revenue Guidance in Effect before and after Topic 606 [Member] | Accounting Standards Update 2014-09 [Member] | Pro Forma [Member]          
Organization And Summary Of Significant Policies [Line Items]          
Accumulated deficit     $ 260,000,000