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Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 12 Months Ended
Dec. 29, 2017
Dec. 30, 2016
Jan. 01, 2016
Revenues:      
Net product revenues $ 349,008 $ 135,375 $ 34,158
Collaboration revenues 103,469 56,079 3,014
Total revenues 452,477 191,454 37,172
Operating expenses:      
Cost of goods sold 15,066 6,552 3,895
Research and development 112,171 95,967 96,351
Selling, general and administrative 159,362 116,145 57,305
Restructuring (recovery) charge (32) 914 1,042
Total operating expenses 286,567 219,578 158,593
Income (loss) from operations 165,910 (28,124) (121,421)
Other income (expense), net:      
Interest income 4,883 2,578 793
Interest expense (8,679) (33,060) (40,680)
Other, net (3,537) (11,616) (381)
Total other expense, net (7,333) (42,098) (40,268)
Income (loss) before income taxes 158,577 (70,222) (161,689)
Provision for income taxes 4,350 0 55
Net income (loss) $ 154,227 $ (70,222) $ (161,744)
Net income (loss) per share, basic (in dollars per share) $ 0.52 $ (0.28) $ (0.77)
Net income (loss) per share, diluted (in dollars per share) $ 0.49 $ (0.28) $ (0.77)
Shares used in computing net income (loss) per share, basic (in shares) 293,588 250,531 209,227
Shares used in computing net income (loss) per share, diluted (in shares) 312,003 250,531 209,227