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Organization and Summary of Significant Accounting Policies - Impact of Adoption of Topic 606 on the Consolidated Statement of Operations (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended
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Mar. 30, 2018 | Mar. 31, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |
Collaboration revenues | $ 78,074 | $ 12,010
Total revenues | 212,346 | 80,887
Income before income taxes | 118,371 | 16,834
Provision for income taxes | 2,514 | 134
Net income | $ 115,857 | $ 16,700
Net income per share, basic (in dollars per share) | $ 0.39 | $ 0.06
Net income per share, diluted (in dollars per share) | $ 0.37 | $ 0.05
Balances Without the Adoption of Topic 606 |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |
Collaboration revenues | $ 46,676 |
Total revenues | 180,948 |
Income before income taxes | 86,973 |
Provision for income taxes | 1,623 |
Net income | $ 85,350 |
Net income per share, basic (in dollars per share) | $ 0.29 |
Net income per share, diluted (in dollars per share) | $ 0.27 |
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |
Collaboration revenues | $ 31,398 |
Total revenues | 31,398 |
Income before income taxes | 31,398 |
Provision for income taxes | 891 |
Net income | $ 30,507 |
Net income per share, basic (in dollars per share) | $ 0.10 |
Net income per share, diluted (in dollars per share) | $ 0.10 |

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