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Organization and Summary of Significant Accounting Policies - Impact of Adoption of Topic 606 on the Consolidated Balance Sheet (Details) - USD ($)
$ in Thousands
Mar. 30, 2018
Dec. 30, 2017
Dec. 29, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]      
Unbilled collaboration revenue $ 31,844   $ 0 [1]
Current portion of deferred revenue 0   31,984 [1]
Other current liabilities 17,711   16,150 [1]
Long-term portion of deferred revenue 3,177   238,520 [1]
Accumulated deficit (1,454,810) $ (1,570,667) (1,829,172) [1]
Balances Without the Adoption of Topic 606      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]      
Unbilled collaboration revenue 0    
Current portion of deferred revenue 30,288    
Other current liabilities 16,820    
Long-term portion of deferred revenue 230,948    
Accumulated deficit (1,743,822)   $ (1,829,172)
ASU 2014-09 | Effect of Adoption Higher / (Lower)      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]      
Unbilled collaboration revenue 31,844    
Current portion of deferred revenue (30,288)    
Other current liabilities 891    
Long-term portion of deferred revenue (227,771)    
Accumulated deficit $ 289,012 $ 258,505  
[1] The Condensed Consolidated Balance Sheet as of December 31, 2017 has been derived from the audited financial statements as of that date.