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Organization and Summary of Significant Accounting Policies - Impact of Adoption of Topic 606 on the Consolidated Statement of Operations (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended
Mar. 30, 2018
Mar. 31, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]    
Collaboration revenues $ 78,074 $ 12,010
Total revenues 212,346 80,887
Income before income taxes 118,371 16,834
Provision for income taxes 2,514 134
Net income $ 115,857 $ 16,700
Net income per share, basic (in dollars per share) $ 0.39 $ 0.06
Net income per share, diluted (in dollars per share) $ 0.37 $ 0.05
Balances Without the Adoption of Topic 606    
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]    
Collaboration revenues $ 46,676  
Total revenues 180,948  
Income before income taxes 86,973  
Provision for income taxes 1,623  
Net income $ 85,350  
Net income per share, basic (in dollars per share) $ 0.29  
Net income per share, diluted (in dollars per share) $ 0.27  
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606    
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]    
Collaboration revenues $ 31,398  
Total revenues 31,398  
Income before income taxes 31,398  
Provision for income taxes 891  
Net income $ 30,507  
Net income per share, basic (in dollars per share) $ 0.10  
Net income per share, diluted (in dollars per share) $ 0.10