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Collaboration Agreements - Takeda Collaboration (Details) - Collaborative Arrangement with Takeda - USD ($)
3 Months Ended
Jan. 01, 2017
Mar. 30, 2018
Mar. 31, 2018
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Upfront payment(s) $ 50,000,000    
Maximum amount eligible for development and regulatory milestones   $ 95,000,000  
Maximum pre-specified payments   $ 83,000,000  
Sales volume period   6 years  
Remaining performance obligation   $ 28,700,000  
Net contract liability     $ 3,200,000
Global      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Research and development arrangement performed for others, reimbursement for costs incurred, percent   20.00%  
Japan      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Research and development arrangement performed for others, reimbursement for costs incurred, percent   100.00%  
Collaboration period to achieve specified levels of commercial performance   2 years  
Initial      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Cumulative net sales   $ 300,000,000.0  
Initial | Minimum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Percent of royalty on net sale   15.00%  
Initial | Maximum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Percent of royalty on net sale   24.00%  
Final | Minimum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Percent of royalty on net sale   20.00%  
Final | Maximum      
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]      
Percent of royalty on net sale   30.00%