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Collaboration Agreements - Ipsen Collaboration (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 6 Months Ended | 23 Months Ended |
--- | --- | --- | --- | --- | ---
Feb. 29, 2016 | Jun. 29, 2018 | Mar. 30, 2018 | Jun. 30, 2017 | Jun. 29, 2018 | Jun. 30, 2017 | Dec. 29, 2017 | Dec. 30, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
License revenues |  | $ 31,908,000 |  | $ 9,156,000 | $ 100,938,000 | $ 20,370,000 |  |  |
Current portion of deferred revenue |  | 5,939,000 |  |  | 5,939,000 |  | $ 31,984,000 | [1] | $ 8,393,000
Long-term portion of deferred revenue |  | 11,970,000 |  |  | $ 11,970,000 |  | 238,520,000 | [1] | $ 25,441,000
Collaborative Arrangement with Ipsen |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Upfront payment(s) | $ 210,000,000 |  |  |  |  |  |  |  |
Milestone payments earned |  |  |  |  |  |  | $ 125,000,000 |  |
Additional milestone achievement | 199,000,000 |  |  |  |  |  |  |  |
Contingent cash receipts (up to) | 519,900,000 |  |  |  |  |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  |  |  |  | 35.00% |  |  |  |
Collaboration period to achieve specified levels of commercial performance |  |  |  |  | 10 years |  |  |  |
Remaining performance obligation |  | 51,600,000 |  |  | $ 51,600,000 |  |  |  |
Net contract liability |  | 15,200,000 |  |  | 15,200,000 |  |  |  |
Current portion of deferred revenue |  | 5,900,000 |  |  | 5,900,000 |  |  |  |
Long-term portion of deferred revenue |  | 9,300,000 |  |  | $ 9,300,000 |  |  |  |
Collaborative Arrangement with Ipsen | GlaxoSmithKline |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  | 3.00% |  |  |  |
Collaborative Arrangement with Ipsen | Initial and Second |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Royalty tier |  |  |  |  | $ 150,000,000 |  |  |  |
Collaborative Arrangement with Ipsen | Initial and Second | Minimum |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  | 22.00% |  |  |  |
Collaborative Arrangement with Ipsen | Initial and Second | Maximum |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  | 26.00% |  |  |  |
Collaborative Arrangement with Ipsen | Initial |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  | 2.00% |  |  |  |
Collaborative Arrangement with Ipsen | Second |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  | 12.00% |  |  |  |
Collaborative Arrangement with Ipsen | EMA Approval - RCC |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Additional milestone achievement |  | 50,000,000 |  |  | $ 50,000,000 |  |  |  |
License revenues |  | $ 200,000 | $ 45,800,000 |  |  |  |  |  |
Collaborative Arrangement with Ipsen | HCC Filing |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Milestone payments earned |  |  |  |  | 10,000,000 |  |  |  |
Collaborative Arrangement with Ipsen | Net Sales Achievements |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Milestone payments earned |  |  |  |  | 25,000,000 |  |  |  |
Net sales achievement level |  |  |  |  | 100,000,000.0 |  |  |  |
Collaborative Arrangement with Ipsen | HCC Acceptance |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
Additional milestone achievement | $ 40,000,000 |  |  |  |  |  |  |  |
Collaborative Arrangement with Ipsen | EMA Approval |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |
License revenues |  |  |  |  | $ 46,000,000 |  |  |  |
[1] | The Condensed Consolidated Balance Sheet as of December 31, 2017 has been derived from the audited financial statements as of that date.

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