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Organization and Summary of Significant Accounting Policies - Impact of Adoption of Topic 606 on the Consolidated Statement of Operations (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 6 Months Ended
--- | --- | ---
Jun. 29, 2018 | Mar. 30, 2018 | Jun. 30, 2017 | Jun. 29, 2018 | Jun. 30, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |
Collaboration revenues | $ 40,272 | $ 79,400 | $ 11,004 | $ 119,719 | $ 23,014
Total revenues | 186,108 | $ 213,700 | 99,008 | 399,827 | 179,895
Income before income taxes | 88,395 |  | 18,237 | 206,766 | 35,071
Provision for income taxes | 901 |  | 581 | 3,415 | 715
Net income | $ 87,494 |  | $ 17,656 | $ 203,351 | $ 34,356
Net income per share, basic (in dollars per share) | $ 0.29 |  | $ 0.06 | $ 0.68 | $ 0.12
Net income per share, diluted (in dollars per share) | $ 0.28 |  | $ 0.06 | $ 0.65 | $ 0.11
Balances Without the Adoption of Topic 606 |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |
Collaboration revenues | $ 94,420 |  |  | $ 142,469 |
Total revenues | 240,256 |  |  | 422,577 |
Income before income taxes | 142,543 |  |  | 229,516 |
Provision for income taxes | 1,906 |  |  | 3,529 |
Net income | $ 140,637 |  |  | $ 225,987 |
Net income per share, basic (in dollars per share) | $ 0.47 |  |  | $ 0.76 |
Net income per share, diluted (in dollars per share) | $ 0.45 |  |  | $ 0.72 |
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |
Collaboration revenues | $ (54,148) |  |  | $ (22,750) |
Total revenues | (54,148) |  |  | (22,750) |
Income before income taxes | (54,148) |  |  | (22,750) |
Provision for income taxes | (1,005) |  |  | (114) |
Net income | $ (53,143) |  |  | $ (22,636) |
Net income per share, basic (in dollars per share) | $ (0.18) |  |  | $ (0.08) |
Net income per share, diluted (in dollars per share) | $ (0.17) |  |  | $ (0.07) |

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