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Organization and Summary of Significant Accounting Policies - Narrative (Details)
$ in Thousands
 3 Months Ended 6 Months Ended 23 Months Ended
Jun. 29, 2018
USD ($)
Mar. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jun. 29, 2018
USD ($)
segment
product
Jun. 30, 2017
USD ($)
Dec. 29, 2017
USD ($)
Dec. 30, 2017
USD ($)
Feb. 29, 2016
USD ($)
Organization And Summary Of Significant Policies [Line Items]                
Number of products that entered in the commercial marketplace | product       3        
Number of business segments | segment       1        
Selling, general and administrative expense $ 51,853 $ 54,000 $ 40,667 $ 105,869 $ 74,955      
Collaboration revenues 40,272 79,400 11,004 119,719 23,014      
Total revenues 186,108 213,700 99,008 399,827 179,895      
Operating expenses 100,338 97,400 71,895 197,750 132,596      
Increase in net cash provided by investing activities       (91,800) 81,719      
Reduction to accumulated deficit (1,367,316)     (1,367,316)   $ (1,829,172) [1] $ (1,570,667)  
Revenue 31,908   9,156 $ 100,938 20,370      
Prompt payment discount rate       2.00%        
Percent of total available discounts expected to be earned       100.00%        
Products Derived from Cabozantinib                
Organization And Summary Of Significant Policies [Line Items]                
Number of products that entered in the commercial marketplace | product       2        
Collaborative Arrangement with Ipsen                
Organization And Summary Of Significant Policies [Line Items]                
Collaboration revenues 34,043   $ 5,494 $ 87,852 10,024      
Milestone payments earned           $ 125,000    
Additional milestone achievement               $ 199,000
Collaborative Arrangement with Ipsen | HCC Filing                
Organization And Summary Of Significant Policies [Line Items]                
Milestone payments earned       10,000        
Collaborative Arrangement with Ipsen | EMA Approval - RCC                
Organization And Summary Of Significant Policies [Line Items]                
Revenue 200 45,800            
Additional milestone achievement 50,000     50,000        
Collaborative Arrangement with Ipsen | EMA Approval                
Organization And Summary Of Significant Policies [Line Items]                
Revenue       46,000        
ASU 2016-18                
Organization And Summary Of Significant Policies [Line Items]                
Increase in net cash provided by investing activities         $ 500      
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606                
Organization And Summary Of Significant Policies [Line Items]                
Collaboration revenues (54,148)     (22,750)        
Total revenues $ (54,148)     $ (22,750)        
Reduction to accumulated deficit             $ 258,505  
Adjustment                
Organization And Summary Of Significant Policies [Line Items]                
Selling, general and administrative expense   1,400            
Collaboration revenues   1,400            
As Previously Reported                
Organization And Summary Of Significant Policies [Line Items]                
Selling, general and administrative expense   52,600            
Collaboration revenues   78,100            
Total revenues   212,300            
Operating expenses   $ 96,000            
[1] The Condensed Consolidated Balance Sheet as of December 31, 2017 has been derived from the audited financial statements as of that date.