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Organization and Summary of Significant Accounting Policies - Impact of Adoption of Topic 606 on the Consolidated Statement of Operations (Details) - USD ($) $ / shares in Units, $ in Thousands	3 Months Ended			6 Months Ended
	Jun. 29, 2018	Mar. 30, 2018	Jun. 30, 2017	Jun. 29, 2018	Jun. 30, 2017
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenues	$ 40,272	$ 79,400	$ 11,004	$ 119,719	$ 23,014
Total revenues	186,108	$ 213,700	99,008	399,827	179,895
Income before income taxes	88,395		18,237	206,766	35,071
Provision for income taxes	901		581	3,415	715
Net income	$ 87,494		$ 17,656	$ 203,351	$ 34,356
Net income per share, basic (in dollars per share)	$ 0.29		$ 0.06	$ 0.68	$ 0.12
Net income per share, diluted (in dollars per share)	$ 0.28		$ 0.06	$ 0.65	$ 0.11
Balances Without the Adoption of Topic 606
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenues	$ 94,420			$ 142,469
Total revenues	240,256			422,577
Income before income taxes	142,543			229,516
Provision for income taxes	1,906			3,529
Net income	$ 140,637			$ 225,987
Net income per share, basic (in dollars per share)	$ 0.47			$ 0.76
Net income per share, diluted (in dollars per share)	$ 0.45			$ 0.72
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]
Collaboration revenues	$ (54,148)			$ (22,750)
Total revenues	(54,148)			(22,750)
Income before income taxes	(54,148)			(22,750)
Provision for income taxes	(1,005)			(114)
Net income	$ (53,143)			$ (22,636)
Net income per share, basic (in dollars per share)	$ (0.18)			$ (0.08)
Net income per share, diluted (in dollars per share)	$ (0.17)			$ (0.07)

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