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Collaboration Agreements - Ipsen Collaboration (Details) - USD ($)	1 Months Ended	3 Months Ended			6 Months Ended		23 Months Ended
	Feb. 29, 2016	Jun. 29, 2018	Mar. 30, 2018	Jun. 30, 2017	Jun. 29, 2018	Jun. 30, 2017	Dec. 29, 2017		Dec. 30, 2017
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
License revenues		$ 31,908,000		$ 9,156,000	$ 100,938,000	$ 20,370,000
Current portion of deferred revenue		5,939,000			5,939,000		$ 31,984,000	[1]	$ 8,393,000
Long-term portion of deferred revenue		11,970,000			$ 11,970,000		238,520,000	[1]	$ 25,441,000
Collaborative Arrangement with Ipsen
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Upfront payment(s)	$ 210,000,000
Milestone payments earned							$ 125,000,000
Additional milestone achievement	199,000,000
Contingent cash receipts (up to)	519,900,000
Research and development arrangement performed for others, reimbursement for costs incurred, percent					35.00%
Collaboration period to achieve specified levels of commercial performance					10 years
Remaining performance obligation		51,600,000			$ 51,600,000
Net contract liability		15,200,000			15,200,000
Current portion of deferred revenue		5,900,000			5,900,000
Long-term portion of deferred revenue		9,300,000			$ 9,300,000
Collaborative Arrangement with Ipsen | GlaxoSmithKline
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale					3.00%
Collaborative Arrangement with Ipsen | Initial and Second
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Royalty tier					$ 150,000,000
Collaborative Arrangement with Ipsen | Initial and Second | Minimum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale					22.00%
Collaborative Arrangement with Ipsen | Initial and Second | Maximum
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale					26.00%
Collaborative Arrangement with Ipsen | Initial
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale					2.00%
Collaborative Arrangement with Ipsen | Second
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Percent of royalty on net sale					12.00%
Collaborative Arrangement with Ipsen | EMA Approval - RCC
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Additional milestone achievement		50,000,000			$ 50,000,000
License revenues		$ 200,000	$ 45,800,000
Collaborative Arrangement with Ipsen | HCC Filing
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone payments earned					10,000,000
Collaborative Arrangement with Ipsen | Net Sales Achievements
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Milestone payments earned					25,000,000
Net sales achievement level					100,000,000.0
Collaborative Arrangement with Ipsen | HCC Acceptance
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Additional milestone achievement	$ 40,000,000
Collaborative Arrangement with Ipsen | EMA Approval
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
License revenues					$ 46,000,000
[1] The Condensed Consolidated Balance Sheet as of December 31, 2017 has been derived from the audited financial statements as of that date.

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