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Condensed Consolidated Statements of Operations - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 6 Months Ended
Jun. 29, 2018
Jun. 30, 2017
Jun. 29, 2018
Jun. 30, 2017
Revenues:        
Net product revenues $ 145,836 $ 88,004 $ 280,108 $ 156,881
Collaboration revenues 40,272 11,004 119,719 23,014
Total revenues 186,108 99,008 399,827 179,895
Operating expenses:        
Cost of goods sold 5,997 3,014 11,636 6,217
Research and development 42,488 28,214 80,245 51,424
Selling, general and administrative 51,853 40,667 105,869 74,955
Total operating expenses 100,338 71,895 197,750 132,596
Income (loss) from operations 85,770 27,113 202,077 47,299
Other income (expense), net:        
Interest income 2,697 1,251 4,592 2,364
Interest expense 0 (4,259) 0 (8,679)
Other, net (72) (5,868) 97 (5,913)
Total other income (expense), net 2,625 (8,876) 4,689 (12,228)
Income (loss) before income taxes 88,395 18,237 206,766 35,071
Income tax expense 901 581 3,415 715
Net income (loss) $ 87,494 $ 17,656 $ 203,351 $ 34,356
Net income per share, basic (in dollars per share) $ 0.29 $ 0.06 $ 0.68 $ 0.12
Net income per share, diluted (in dollars per share) $ 0.28 $ 0.06 $ 0.65 $ 0.11
Shares used in computing net income per share, basic (in shares) 297,336 293,188 296,874 292,029
Shares used in computing net income per share, diluted (in shares) 312,241 311,219 313,024 310,759