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Collaboration Agreements - Takeda Collaboration (Details) - Collaborative Arrangement with Takeda - USD ($) |  | 9 Months Ended
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Jan. 01, 2017 | Sep. 28, 2018
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Upfront payment(s) | $ 50,000,000 |
Maximum amount eligible for development and regulatory milestones |  | $ 100,000,000
Maximum pre-specified payments |  | $ 83,000,000
Sales volume period |  | 6 years
Remaining performance obligation |  | $ 28,500,000
Net contract liability |  | $ 2,300,000
Global |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 20.00%
Japan |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 100.00%
Collaboration period to achieve specified levels of commercial performance |  | 2 years
Initial |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Cumulative net sales |  | $ 300,000,000.0
Initial | Minimum |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 15.00%
Initial | Maximum |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 24.00%
Final | Minimum |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 20.00%
Final | Maximum |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 30.00%

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