<SEC-DOCUMENT>0001193125-18-114961.txt : 20180412
<SEC-HEADER>0001193125-18-114961.hdr.sgml : 20180412
<ACCEPTANCE-DATETIME>20180412084557
ACCESSION NUMBER:		0001193125-18-114961
CONFORMED SUBMISSION TYPE:	DEF 14A
PUBLIC DOCUMENT COUNT:		18
CONFORMED PERIOD OF REPORT:	20180523
FILED AS OF DATE:		20180412
DATE AS OF CHANGE:		20180412
EFFECTIVENESS DATE:		20180412

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0102

	FILING VALUES:
		FORM TYPE:		DEF 14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		18751227

	BUSINESS ADDRESS:	
		STREET 1:		210 E. GRAND AVE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		210 E. GRAND AVE
		CITY:			SOUTH SAN FRANCISCO
		STATE:			CA
		ZIP:			94080

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEF 14A
<SEQUENCE>1
<FILENAME>d489684ddef14a.htm
<DESCRIPTION>DEF 14A
<TEXT>
<HTML><HEAD>
<TITLE>DEF 14A</TITLE>
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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:16pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>UNITED STATES</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:16pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>SECURITIES AND EXCHANGE COMMISSION</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Washington, D.C. 20549</B> </FONT></P> <P STYLE="font-size:10pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center>
<P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:16pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>SCHEDULE 14A</B> </FONT></P><center>
<P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Proxy Statement Pursuant to Section&nbsp;14(a) of the Securities</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Exchange Act of 1934 (Amendment No.&nbsp;&nbsp;&nbsp;&nbsp;)</B> </FONT></P>
<P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Filed by the Registrant <FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9746;</FONT> </FONT></P>
<P STYLE="margin-top:2pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Filed by a Party other than the Registrant <FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT> </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Check the appropriate box: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


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<TD WIDTH="95%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Preliminary Proxy Statement</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f"><B>Confidential, for Use of the Commission Only (as permitted by Rule <FONT STYLE="white-space:nowrap">14a-6(e)(2))</FONT></B></FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9746;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Definitive Proxy Statement</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Definitive Additional Materials</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Soliciting Material Pursuant to <FONT STYLE="white-space:nowrap">&#167;240.14a-12</FONT></FONT></TD></TR>
</TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f;width:21%">&nbsp;</P></center>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="center">


<IMG SRC="g489684g87b92.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:16pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>EXELIXIS, INC.</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f">(Exact name of registrant as specified in its charter) </FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><center> <P STYLE="line-height:6.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f;width:21%">&nbsp;</P></center>
<P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f">(Name of Person(s) Filing Proxy Statement, if other than the Registrant) </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Payment of Filing Fee (Check the appropriate box): </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="88%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9746;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" COLSPAN="4"><FONT COLOR="#3f3f3f">No fee required.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" COLSPAN="4"><FONT COLOR="#3f3f3f">Fee computed on table below per Exchange Act Rules <FONT STYLE="white-space:nowrap">14a-6(i)(1)</FONT> and <FONT STYLE="white-space:nowrap">0-11.</FONT></FONT></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(1</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Title of each class of securities to which transaction applies:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(2</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Aggregate number of securities to which transaction applies:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="top" ALIGN="right"><FONT COLOR="#3f3f3f">(3</FONT></TD>
<TD NOWRAP VALIGN="top"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Per unit price or other underlying value of transaction computed pursuant to Exchange Act <FONT STYLE="white-space:nowrap">Rule&nbsp;0-11</FONT> (set forth the amount on which the filing fee is calculated
and state how it was determined):</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(4</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Proposed maximum aggregate value of transaction:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(5</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Total fee paid:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" COLSPAN="4"><FONT COLOR="#3f3f3f">Fee paid previously with preliminary materials.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><FONT STYLE="font-family:Times New Roman" COLOR="#3f3f3f">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;<BR><BR></FONT></TD>
<TD VALIGN="bottom" COLSPAN="4"><FONT COLOR="#3f3f3f">Check box if any part of the fee is offset as provided by Exchange Act Rule <FONT STYLE="white-space:nowrap">0-11(a)(2)</FONT> and identify the<BR>filing for which the offsetting fee was paid
previously. Identify the previous filing by registration<BR>statement number, or the Form or Schedule and the date of its filing.</FONT></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8"></TD>
<TD HEIGHT="8" COLSPAN="4"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(1</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Amount Previously Paid:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(2</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Form, Schedule or Registration Statement No.:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(3</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Filing Party:</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">(4</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Date Filed:</FONT></TD></TR>
</TABLE>
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<IMG SRC="g489684g87b92.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">210 East Grand Ave. </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">South San Francisco, CA 94080 </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:22pt; font-family:arial"><FONT
 COLOR="#6d6d6d">N<SMALL>OTICE</SMALL> <SMALL>OF</SMALL> A<SMALL>NNUAL</SMALL> M<SMALL>EETING </SMALL><SMALL>OF</SMALL> S<SMALL>TOCKHOLDERS</SMALL> </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT
 COLOR="#ff4c00">To be held on MAY&nbsp;23, 2018 </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">To the Stockholders of Exelixis, Inc.: </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>NOTICE IS HEREBY GIVEN</B> that the Annual Meeting of Stockholders of Exelixis, Inc., a Delaware corporation (&#147;Exelixis&#148;), will be
held on Wednesday, May&nbsp;23, 2018, at 8:00 a.m., local time, at Exelixis&#146; offices located at 210&nbsp;East Grand Avenue, South San Francisco, California 94080 for the following purposes: </FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#ff4c00">1.</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">To elect the three Class&nbsp;I nominees for director named in the Proxy Statement accompanying this Notice to hold office until the 2021 Annual Meeting of Stockholders. </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#ff4c00">2.</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">To ratify the selection by the Audit Committee of the Board of Directors of Ernst&nbsp;&amp; Young LLP as Exelixis&#146; independent registered public accounting firm for the fiscal year ending
December&nbsp;28, 2018. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#ff4c00">3.</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">To approve, on an advisory basis, the compensation of Exelixis&#146; named executive officers, as disclosed in the Proxy Statement accompanying this Notice. </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#ff4c00">4.</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">To conduct any other business properly brought before the meeting. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">These items of business are more fully described in the Proxy Statement accompanying this Notice. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We are mailing to most of our stockholders a Notice of Internet Availability of Proxy Materials (the &#147;Notice&#148;) instead of a paper copy of
this Proxy Statement and our 2017 Annual Report. The Notice contains instructions on how to access those documents over the Internet. The Notice also contains instructions on how to request a paper copy of our proxy materials, including this Proxy
Statement, our 2017 Annual Report and a form of proxy card or voting instruction card. All stockholders who do not receive a Notice will receive a paper copy of the proxy materials by mail. We believe that this process will allow us to provide our
stockholders with the information they need in a more timely manner, while reducing the environmental impact and lowering the costs of printing and distributing our proxy materials. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The record date for the Annual Meeting is March&nbsp;29, 2018. Only stockholders of record at the close of business on that date may vote at the
meeting or any postponement or adjournment thereof. </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" STYLE="BORDER:1px solid #ff4c00; padding-left:8pt; padding-right:2pt"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.60em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Important notice regarding the
availability of proxy materials for the Annual Meeting of Stockholders to be held on May&nbsp;23, 2018, at 8:00&nbsp;a.m., local time, at Exelixis&#146; offices located at 210 East Grand Avenue, South San Francisco, CA&nbsp;94080. </B></FONT></P>
<P STYLE="font-size:6pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.60em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>The Proxy Statement and Annual Report to stockholders
are available at&nbsp;</B><B><I><FONT STYLE="white-space:nowrap">www.exel-annualstockholdermeeting.com</FONT></I></B><B>.</B></FONT></P> <P STYLE="font-size:6pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.60em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>The Board of Directors recommends that you vote &#147;FOR&#148; Proposal Nos. <FONT STYLE="white-space:nowrap">1-3</FONT>
identified above.</B></FONT></P> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:1pt">&nbsp;</P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">By Order of the Board of Directors </FONT></P>
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 </P> <P STYLE="margin-top:4pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">JEFFREY J. HESSEKIEL </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Executive Vice President and General Counsel </FONT></P> <P STYLE="margin-top:3pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">South San Francisco, California </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">April&nbsp;12, 2018 </FONT></P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>YOUR VOTE IS IMPORTAN</B><B>T</B> </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">WHETHER OR NOT YOU PLAN TO ATTEND THE 2018 ANNUAL MEETING OF STOCKHOLDERS, TO ENSURE THAT YOU ARE REPRESENTED AT THE MEETING AND TO ENSURE THAT A
QUORUM IS PRESENT, WE URGE YOU TO VOTE YOUR PROXY ONLINE, BY TELEPHONE OR BY RETURNING A PROXY CARD BY MAIL AS INSTRUCTED IN THE NOTICE OF AVAILABILITY OF PROXY MATERIALS. EVEN IF YOU HAVE VOTED BY PROXY, YOU MAY STILL VOTE IN PERSON IF YOU ATTEND
THE ANNUAL MEETING. PLEASE NOTE, HOWEVER, THAT IF YOU HOLD YOUR SHARES THROUGH A BROKER, BANK OR OTHER NOMINEE, THEN THAT ENTITY IS THE STOCKHOLDER OF RECORD, AND YOU WILL NEED TO FOLLOW THE INSTRUCTIONS ON THE INSTRUCTION FORM THEY SEND TO YOU AND
THEY WILL VOTE YOUR SHARES AS YOU DIRECT, OR YOU MUST OBTAIN A PROXY ISSUED IN YOUR NAME FROM THAT ENTITY TO VOTE YOUR SHARES. </FONT></P>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Questions and
Answers&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Proxy Materials and Voting </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
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 </P> <P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">210 East Grand Ave. </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">South San Francisco, CA 94080 </FONT></P> <P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:22pt; font-family:arial"><FONT
 COLOR="#6d6d6d">P<SMALL>ROXY</SMALL> S<SMALL>TATEMENT</SMALL> </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:22pt; font-family:arial"><FONT COLOR="#ff4c00">F<SMALL>OR</SMALL> <SMALL>THE</SMALL> 2018 A<SMALL>NNUAL</SMALL>
M<SMALL>EETING</SMALL> <SMALL>OF</SMALL> S<SMALL>TOCKHOLDERS</SMALL> </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">MAY&nbsp;23, 2018 </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#ff4c00">QUESTIONS AND ANSWERS ABOUT THESE PROXY MATERIALS AND VOTING </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Why am I receiving these materials? </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">We have made these materials available to you on the Internet or, upon your request, have delivered printed versions of these materials to you by mail because the Board of Directors, or the Board, of Exelixis, Inc. (sometimes
referred to as &#147;we,&#148; &#147;us&#148; or &#147;Exelixis&#148;) is soliciting your proxy to vote at the 2018 Annual Meeting of Stockholders, or the Annual Meeting, including at any adjournments or postponements of the meeting. The Annual
Meeting will be held on Wednesday, May&nbsp;23, 2018, at 8:00 a.m., local time, at our offices at the address set forth above. We invite you to attend the Annual Meeting to vote on the proposals described in this proxy statement. However, you do not
need to attend the Annual Meeting to vote your shares. Instead, you may simply complete, sign and return a proxy card, or follow the instructions below or in the Notice of Internet Availability of Proxy Materials described below to submit your proxy
over the telephone or on the Internet. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We intend to send or make available these materials to stockholders on April 12, 2018.
</FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What is included in these proxy materials? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">These proxy materials include: </FONT></P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The Notice of the 2018 Annual Meeting of Stockholders; </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The Proxy Statement for the Annual Meeting; and </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, as filed with the Securities and Exchange Commission, or SEC, on
February&nbsp;26, 2018, or the Annual Report. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you requested printed versions by mail, these proxy materials also
include the proxy card or voting instruction form for the Annual Meeting. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Why did I receive a
<FONT STYLE="white-space:nowrap">one-page</FONT> notice in the mail regarding Internet availability of proxy materials instead of a full set of printed proxy materials? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Pursuant to rules adopted by the SEC, we have elected to use the Internet as the primary means of furnishing proxy materials to our stockholders
this year. This method allows us to deliver the proxy materials to you more quickly, lowers our costs significantly and helps to conserve natural resources. Accordingly, we are sending a Notice of Internet Availability of Proxy Materials, or Notice
of Availability, to our stockholders who have not asked us to provide proxy materials in printed form. All stockholders receiving a Notice of Availability can request a printed set of proxy materials. Moreover, all stockholders can access the proxy
materials at <I>www.exel-annualstockholdermeeting.com</I>, irrespective of whether they receive a Notice of Availability or a printed copy of the proxy materials. Instructions on how to access the proxy materials on the Internet or how to request a
printed copy may be found in the Notice of Availability and in this Proxy Statement. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In addition, a stockholder may ask to receive
proxy materials in printed form by mail or electronically by email on an ongoing basis. We encourage stockholders to take advantage of the option to receive proxy materials electronically by email to help reduce the environmental impact of our
annual meeting and to reduce costs associated with the physical printing and mailing of materials. If you choose to receive future proxy materials by email, you will receive an email message next year with instructions containing a link to those
materials and a link to the proxy voting website. Your election to receive proxy materials by email will remain in effect until you terminate it. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">1</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Who may vote at the Annual Meeting? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Only stockholders of record at the close of business on March&nbsp;29, 2018, the Record Date, will be entitled to vote at the Annual Meeting. On
the Record Date, there were 296,659,164 shares of common stock outstanding and entitled to vote. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00">Stockholder of Record: Shares
Registered in Your Name </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If on March&nbsp;29, 2018, your shares were registered directly in your name with our transfer agent,
Computershare Trust Company, N.A., then you are a stockholder of record. As a stockholder of record, you may vote in person at the meeting or vote by proxy. Whether or not you plan to attend the Annual Meeting, we urge you to vote by proxy over the
telephone or on the Internet as instructed below, or complete and mail the proxy card if you received printed materials. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00">Beneficial
Owner: Shares Registered in the Name of a Broker, Bank or Other Stockholder of Record </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If on March&nbsp;29, 2018, your shares were held
in an account at a brokerage firm, bank, dealer, or other similar organization, then you are the beneficial owner of shares held in &#147;street name,&#148; and these proxy materials are being forwarded to you by that organization. The organization
holding your shares is considered to be the stockholder of record for purposes of voting at the Annual Meeting. As a beneficial owner, you have the right to direct your broker, bank or other stockholder of record regarding how to vote the shares in
your account, and you will receive instructions from your broker, bank or other stockholder of record that must be followed in order for your broker, bank or other stockholder of record to vote your shares per your instructions. You are also invited
to attend the Annual Meeting. However, since you are not the stockholder of record, you may not vote your shares in person at the meeting unless you request and obtain a valid proxy from your broker, bank or other stockholder of record giving you
the right to vote such shares in person at the Annual Meeting. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What am I voting on? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">There are three matters scheduled for a vote at the 2018 Annual Meeting. They are as follows: </FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Election of the three Class&nbsp;I nominees for director named herein to hold office until the 2021 Annual Meeting of Stockholders; </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Ratification of Ernst&nbsp;&amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December&nbsp;28, 2018; and </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Advisory approval of the compensation of our named executive officers, as disclosed in this Proxy Statement. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>How do I vote? </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Whether or
not you plan to attend the meeting, we urge you to vote by proxy to ensure your vote is counted. You may still attend the meeting and vote in person even if you have already voted by proxy. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00">Stockholder of Record: Shares Registered in Your Name </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">If you are a stockholder of record, you have four ways to vote. </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<BR> <P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>In&nbsp;Person</B></FONT></P></TD>
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<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">To vote in person, come to the Annual Meeting and we will give you a ballot when you arrive. You must bring valid photo identification such as a driver&#146;s license or passport and may
be asked to provide proof of stock ownership, such as your account statement, as of the Record Date, March&nbsp;29, 2018.</FONT></TD></TR>
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<BR> <P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Via&nbsp;Internet</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">To vote on the Internet, go to www.investorvote.com/EXEL and follow the instructions provided in the Notice of Availability. Your vote must be received by 11:59 p.m., Eastern Time, on
May&nbsp;22, 2018, to be counted.</FONT></TD></TR>
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<BR> <P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>By&nbsp;Telephone</B></FONT></P></TD>
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<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">To vote by telephone, request a paper or email copy of the proxy materials by following the instructions provided in the Notice of Availability and call the number provided with the proxy
materials to transmit your voting instructions. Your vote must be received by 11:59 p.m. Eastern Time, on May&nbsp;22, 2018, to be counted.</FONT></TD></TR>
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<BR> <P STYLE="margin-bottom:1pt; margin-top:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>By Mail</B></FONT></P></TD>
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<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
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<TD VALIGN="top"><FONT STYLE="font-size:10pt" COLOR="#3f3f3f">To vote by mail, request a paper copy of the proxy materials by following the instructions provided in the Notice of Availability and complete, sign and date the proxy card enclosed with
the paper copy of the proxy materials and return it promptly in the envelope that will be provided. If you return your signed proxy card to us before the Annual Meeting, we will vote your shares as you direct.</FONT></TD></TR>
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 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">2</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Questions and
Answers&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Proxy Materials and Voting </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00">Beneficial Owner: Shares Registered in the Name of Broker, Bank or Other Stockholder of Record (<I>i.e., &#147;Street Name&#148;</I>) </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you are a beneficial owner of shares registered in the name of your broker, bank, or other stockholder of record, you should have received the
Notice of Availability containing voting instructions from that organization rather than from us. You must follow these instructions for your bank, broker or other stockholder of record to vote your shares per your instructions. Alternatively, many
brokers and banks provide the means to grant proxies to vote shares by telephone and via the Internet. If your shares are held in an account with a broker, bank or other stockholder of record providing such a service, you may grant a proxy to vote
those shares by telephone or over the Internet as instructed by your broker, bank or other stockholder of record. To vote in person at the Annual Meeting, you must obtain a valid proxy from your broker, bank or other stockholder of record. Follow
the instructions from your broker, bank or other stockholder of record included with these proxy materials, or contact your broker, bank or other stockholder of record to request a proxy form. </FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" STYLE="BORDER:1px solid #ff4c00; padding-left:8pt; padding-right:2pt"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.60em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>We provide Internet proxy voting
to allow you to vote your shares online, with procedures designed to ensure the authenticity and correctness of your proxy vote instructions. However, please be aware that you must bear any costs associated with your Internet access, such as usage
charges from Internet access providers and telephone companies.</B></FONT></P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>How many votes do I have? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">On each matter to be voted upon, you have one vote for each share of common stock you own as of the Record Date, March&nbsp;29, 2018. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>How are proxies voted? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">All shares represented by valid proxies received prior to the taking of the vote at the Annual Meeting will be voted and, where a stockholder
specifies by means of a proxy a choice with respect to any matter to be acted upon, the shares will be voted in accordance with the stockholder&#146;s instructions. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What if I return a proxy card but do not make specific choices? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you are a stockholder of record and you return a signed and dated proxy card without marking any voting selections, your shares will be voted on
the proposals as follows: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;For&#148; the election of Drs. Cohen and Poste and Mr.&nbsp;Wyszomierski as described in Proposal&nbsp;1; </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;For&#148; the ratification of our selection of Ernst&nbsp;&amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December&nbsp;28, 2018, as described
in Proposal&nbsp;2; and </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;For&#148; the advisory approval of the compensation of our named executive officers as described in Proposal&nbsp;3. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If any other matter is properly presented at the Annual Meeting, your proxyholder (one of the individuals named on your proxy card) will vote your
shares using his best judgment. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you are a beneficial owner of shares registered in the name of your broker, bank or other
stockholder of record and you do not provide the broker, bank or other stockholder of record holding your shares with voting instructions, your broker, bank or other stockholder of record will determine if it has the discretionary authority to vote
on the particular matter. If you are a beneficial owner whose shares are held of record by a broker and you do not provide voting instructions, your shares will not be voted on any proposal on which the broker does not have discretionary authority
to vote. This is called a &#147;broker <FONT STYLE="white-space:nowrap">non-vote.&#148;</FONT> In these cases, the broker can register your shares as being present at the Annual Meeting for purposes of determining the presence of a quorum, but will
not be able to vote on those matters for which specific authorization is required under the rules of the New York Stock Exchange. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If
you are a beneficial owner whose shares are held of record by a broker, your broker has discretionary voting authority under the rules of the New York Stock Exchange to vote your shares on Proposal No.&nbsp;2 (the ratification of the appointment of
Ernst&nbsp;&amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December&nbsp;28, 2018), even if your broker does not receive voting instructions from you. However, your broker does not have discretionary
authority to vote on Proposal No.&nbsp;1 or Proposal No.&nbsp;3 without voting instructions from you, in which case a broker <FONT STYLE="white-space:nowrap">non-vote</FONT> will occur and your shares will not be voted on Proposal No.&nbsp;1 or
Proposal No.&nbsp;3. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Who is paying for this proxy solicitation? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We are soliciting proxies and will bear the entire cost of soliciting proxies, including the preparation, printing and mailing of the Notice of
Availability, the Notice of Annual Meeting, the Proxy Statement, the proxy card and any additional information </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">3</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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furnished to stockholders. Copies of solicitation materials will be furnished to banks, brokerage houses, fiduciaries and custodians holding in their names shares of our common stock beneficially
owned by others to forward to such beneficial owners. We may reimburse persons representing beneficial owners of our common stock for their costs of forwarding solicitation materials to such beneficial owners. Original solicitation of proxies by
mail may be supplemented by telephone, telegram or personal solicitation by our directors, officers or other regular employees. No additional compensation will be paid to directors, officers or other regular employees for such services. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What does it mean if I receive more than one Notice of Availability or proxy card? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you receive more than one Notice of Availability or proxy card, your shares are registered in more than one name or are registered in different
accounts. Please follow the instructions on each Notice of Availability or proxy card to ensure that all of your shares are voted. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Can I change my vote after submitting my proxy? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Yes. You can revoke your proxy at any time before the final vote at the Annual Meeting. You may revoke your proxy in the following ways:
</FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00">Stockholder of Record: Shares Registered in Your Name </FONT></P>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Your proxy may be revoked by filing with the Secretary of Exelixis at our principal executive office, Exelixis, Inc., 210 East Grand Avenue, South San Francisco, California 94080, either (1)&nbsp;a
written notice of revocation or (2)&nbsp;a duly executed proxy card bearing a later date. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Your proxy may also be revoked by granting a subsequent proxy by telephone or on the Internet (your latest telephone or Internet proxy is the one that is counted). </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Your proxy may also be revoked by attending the Annual Meeting and voting in person. Attendance at the Annual Meeting will not, by itself, revoke your proxy. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00">Beneficial Owner: Shares Registered in the Name of Broker, Bank or Other Stockholder of Record </FONT></P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">If your shares are held by your broker or bank as nominee or agent, you should follow the instructions provided by your broker or bank to revoke any prior voting instructions.
</FONT></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What is the quorum requirement for the Annual Meeting? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">A majority of the outstanding shares entitled to vote at the Annual Meeting must be present at the Annual Meeting, either in person or by proxy, to
hold a valid meeting. This is called a &#147;quorum.&#148; </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you are a stockholder of record, your shares will be counted towards the
quorum only if you vote in person at the meeting or have properly voted by proxy on the Internet, by telephone or by submitting a proxy card by mail or at the Annual Meeting. You may vote &#147;For,&#148; &#147;Against&#148; or &#147;Abstain&#148;
with respect to Proposals 1, 2 and 3. Abstentions will be counted towards the number of shares considered to be present at the meeting for purposes of determining whether a quorum is present. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you are a beneficial owner holding your shares in &#147;street name&#148; then only the broker, bank or other stockholder of record can vote
your shares unless you obtain a valid proxy from the broker, bank or other stockholder of record. See &#147;What if I return a proxy card but do not make specific choices?&#148; above. Shares represented by &#147;broker <FONT
STYLE="white-space:nowrap">non-votes&#148;</FONT> will be counted in determining whether there is a quorum present. Votes will be counted by the inspector of election appointed for the Annual Meeting. If there is no quorum, either the chairman of
the Annual Meeting or the holders of a majority of shares present at the Annual Meeting in person or represented by proxy may adjourn the Annual Meeting to another date. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>How many votes are needed to approve each proposal, how are votes counted, and how are abstentions and broker
<FONT STYLE="white-space:nowrap">non-votes</FONT> treated? </B></FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f"><B><I>Proposal <FONT STYLE="white-space:nowrap">1-Election</FONT> of Directors:</I></B> Directors in an uncontested election, such as this one, are elected by a majority of the votes cast. Each of
the three Class&nbsp;I nominees must receive &#147;For&#148; votes from the holders of a majority of shares cast with respect to such director (i.e., the number of shares voted &#147;For&#148; a director must exceed the number of shares voted
&#147;Against&#148; that director). Abstentions and broker <FONT STYLE="white-space:nowrap">non-votes,</FONT> if any, are not counted for purposes of electing directors and will have no effect on the results of this vote. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">4</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Questions and
Answers&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Proxy Materials and Voting </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f"><B><I>Proposal <FONT STYLE="white-space:nowrap">2-Ratification</FONT> of Ernst&nbsp;&amp; Young LLP: </I></B>The affirmative vote of a majority of shares present in person or represented by proxy
at the Annual Meeting and entitled to vote on the proposal is required to ratify the selection of Ernst&nbsp;&amp; Young LLP as our independent registered public accounting firm for the fiscal year ending December&nbsp;28, 2018. Abstentions will
have the effect of votes against this proposal. Brokers generally have discretionary authority to vote on the ratification of our independent accounting firm; thus we do not expect any broker <FONT STYLE="white-space:nowrap">non-votes</FONT> on this
proposal. To the extent there are any broker <FONT STYLE="white-space:nowrap">non-votes,</FONT> they will have no effect on the results of this proposal. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f"><B><I></I></B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f"><B><I>Proposal <FONT STYLE="white-space:nowrap">3-Advisory</FONT> Vote on Executive Compensation:</I></B> The affirmative vote of a majority of shares present in person or by represented proxy at
the Annual Meeting and entitled to vote on the proposal is required to approve the <FONT STYLE="white-space:nowrap">non-binding,</FONT> advisory vote on executive compensation. Abstentions will be counted toward the tabulation of votes cast on the
proposal and will have the same effect as votes against this proposal. Broker <FONT STYLE="white-space:nowrap">non-votes</FONT> will have no effect and will not be counted towards the vote total. Since the vote is advisory, it is not binding on the
Board or on us. Nevertheless, the views expressed by our stockholders, whether through this vote or otherwise, are important to the Compensation Committee and the Board and, accordingly, the Compensation Committee and Board intend to consider the
results of this vote in making determinations in the future regarding executive compensation arrangements. Your vote will serve as an additional tool to guide the Compensation Committee and Board in continuing to improve the alignment of our
executive compensation programs with business objectives and performance and with the interests of our stockholders. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Do I have dissenters&#146; rights? </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">No. We are organized as a corporation under Delaware law. Under the Delaware General Corporation Law, our stockholders are not entitled to dissenters&#146; rights with respect to any of the proposals set forth in this Proxy
Statement and we will not independently provide the stockholders with any such rights. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>How can I find out the results of the voting
at the Annual Meeting? </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Preliminary voting results will be announced at the Annual Meeting. In addition, final voting results will
be published in a current report on Form <FONT STYLE="white-space:nowrap">8-K</FONT> that we expect to file within four business days after the Annual Meeting. If final voting results are not available to us in time to file a Form <FONT
STYLE="white-space:nowrap">8-K</FONT> within four business days after the Annual Meeting, we intend to file a Form <FONT STYLE="white-space:nowrap">8-K</FONT> to publish preliminary results and, within four business days after the final results are
known to us, file an additional Form <FONT STYLE="white-space:nowrap">8-K</FONT> to publish the final results. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Will other matters
be voted on at the Annual Meeting? </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We are not aware of any matters to be presented at the Annual Meeting other than those described
in this Proxy Statement. If any other matters not described in the Proxy Statement are properly presented at the meeting, proxies will be voted in accordance with the best judgment of the proxyholders. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What proxy materials are available on the Internet? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">This Proxy Statement and our 2017 Annual Report are available at <I>www.exel-annualstockholdermeeting.com</I>. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>What is the deadline for submitting stockholder proposals for the 2019 Annual Meeting? </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">To be considered for inclusion in the 2019 proxy materials, your proposal must be submitted in writing by December&nbsp;13, 2018, to Exelixis&#146;
Secretary at Exelixis, Inc., 210 East Grand Avenue, South San Francisco, California 94080, and you must comply with all applicable requirements of Rule <FONT STYLE="white-space:nowrap">14a-8</FONT> promulgated under the Securities Exchange Act of
1934, as amended. However, if our 2019 Annual Meeting of Stockholders is held before April&nbsp;23, 2019, or after June&nbsp;22, 2019, then the deadline will be a reasonable time prior to the time that we make our proxy materials available to our
stockholders, either online or in printed form. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If you wish to submit a proposal or nominate a director at the 2019 Annual Meeting of
Stockholders, but you are not requesting that your proposal or nomination be included in next year&#146;s proxy materials, you must submit your proposal in writing, in the manner set forth in our Bylaws, to Exelixis&#146; Secretary at Exelixis,
Inc., 210 East Grand Avenue, South San Francisco, California 94080, to be received no earlier than the close of business on February&nbsp;22, 2019, and no later than the close of business on March&nbsp;24, 2019. However, if our 2019 Annual Meeting
of Stockholders is held before April&nbsp;23, 2019, or after June&nbsp;22, 2019, then you must notify Exelixis&#146; Secretary, in writing, not earlier than the close of business on the 90th day prior to the date of the 2019 Annual Meeting of
Stockholders and not later than the close of business on the later of (i)&nbsp;the 60th day prior to the date of the 2019 Annual Meeting of Stockholders or (ii)&nbsp;if we publicly announce the date of the
</FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">5</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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2019 Annual Meeting of Stockholders fewer than 70 days prior to the date of the 2019 Annual Meeting of Stockholders, the 10th day following the day that we first make such public announcement of
the date of the 2019 Annual Meeting of Stockholders. We also advise you to review our Bylaws, which contain additional requirements about advance notice of stockholder proposals and director nominations. The chairperson of the 2019 Annual Meeting of
Stockholders may determine, if the facts warrant, that a matter has not been properly brought before the meeting and, therefore, may not be considered at the meeting. In addition, unless prohibited by Rule
<FONT STYLE="white-space:nowrap">14a-4(c)</FONT> promulgated under the Securities Exchange Act of 1934, as amended, our management will have discretionary authority to vote all shares for which it has proxies for any such stockholder proposal or
director nomination, including in opposition to such stockholder proposal or director nomination. </FONT></P> <P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>How may I obtain a printed copy
of the Proxy Materials? </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Instructions on how to obtain a printed copy of the proxy materials are set forth in the Notice of
Availability. </FONT></P> <P STYLE="margin-top:10pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Directions to the Annual Meeting </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:11pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>210 East Grand Avenue </B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:11pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>South San Francisco, CA 94080 </B></FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:14pt; font-family:arial" ALIGN="center"><FONT COLOR="#ff4c00"><B>Airport/San Jose</B></FONT></P></TD>
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<TD VALIGN="middle" ALIGN="center" STYLE="BORDER-TOP:1.00pt solid #ff4c00"><FONT STYLE="font-size:14pt" COLOR="#ff4c00"><B>From the City of San Francisco</B></FONT></TD></TR>


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<TD VALIGN="top" ALIGN="center" BGCOLOR="#e5e5e5"><FONT STYLE="font-size:12pt" COLOR="#3f3f3f"><B>Via Highway 101 North</B></FONT></TD>
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<TD VALIGN="bottom" ALIGN="center" BGCOLOR="#e5e5e5"><FONT STYLE="font-size:12pt" COLOR="#3f3f3f"><B>Via Highway 101 South</B></FONT></TD></TR>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Highway 101 North</FONT></P>
<P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Take exit 425A towards Grand Avenue</FONT></P>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Turn right onto Grand Avenue</FONT></P>
<P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Turn right at first light onto East Grand
Avenue</FONT></P> <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT
 COLOR="#3f3f3f">&#8201;&#8201;210 East Grand Avenue will be the first building on&nbsp;your right after crossing light at Harbor Way.</FONT></P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Highway 101 South</FONT></P>
<P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Take exit 425A towards Grand Avenue</FONT></P>
<P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Turn left at first light onto Airport
Boulevard</FONT></P> <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT
 COLOR="#3f3f3f">&#8201;&#8201;Turn left at first light onto Grand Avenue</FONT></P> <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;Grand Avenue becomes East Grand Avenue</FONT></P>
<P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#ff783f">&#149;</FONT><FONT COLOR="#3f3f3f">&#8201;&#8201;210 East Grand Avenue will be the first building
on&nbsp;your right after crossing light at Harbor Way</FONT></P></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Directions to our Annual Meeting may also be found on our website at:
<I>www.exelixis.com/about/locations-and-directions</I>. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">6</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Proposal 1&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT
STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Election of Class I Directors </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT
 COLOR="#ff4c00">P<SMALL>ROPOSAL</SMALL> 1 </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#6d6d6d">E<SMALL>LECTION</SMALL> <SMALL>OF</SMALL> C<SMALL>LASS</SMALL> I D<SMALL>IRECTORS</SMALL>
</FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Our Certificate of Incorporation and Bylaws provide that the Board is divided into three classes, with each class having a three-year
term. As of the date of this Proxy Statement, the Board has twelve members &#151; three Class&nbsp;I directors, five Class&nbsp;II directors and four Class&nbsp;III directors. On April 5, 2018, the Board elected Maria C. Freire, Ph.D. to serve as a
member of the Board. The Board elected Dr. Freire to the Board as a Class II director (so that her term will expire at next year&#146;s annual meeting) after weighing various factors, including the timing of Dr. Freire&#146;s election to our Board
and the proximity of that timing to our deadline for finalizing our proxy materials and the Board&#146;s desire that our stockholders have the opportunity to vote on her election to the Board in the near term. The term of office for each of the
three directors in Class&nbsp;I will expire at the Annual Meeting. Each of the director nominees set forth in this Proxy Statement is currently a director of Exelixis who was previously elected by the stockholders. If elected at the Annual Meeting,
each of these nominees would serve until the 2021 Annual Meeting and until his successor is elected and has qualified, or, if sooner, until the director&#146;s death, resignation or removal. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">As this is an uncontested election, each director will be elected by a majority of the votes cast at the meeting with respect to the election of
that director. A majority of the votes cast means that the number of shares voted &#147;for&#148; a director must exceed the number of votes cast &#147;against&#148; that director. If any nominee becomes unavailable for election as a result of an
unexpected occurrence, your shares will be voted for the election of such substitute nominee as the Board, after receiving the recommendation of the Nominating and Corporate Governance Committee of the Board, may propose. Each person nominated for
election has agreed to serve if elected, and we have no reason to believe that any nominee will be unable to serve. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">All director
nominees set forth in this Proxy Statement have tendered an irrevocable resignation as a director conditioned upon (i)&nbsp;such director failing to receive a majority of the votes cast at the Annual Meeting, and (ii)&nbsp;acceptance by the Board of
such resignation. If a director nominee who is serving as a director at the time of the election does not receive a majority of the votes cast at the Annual Meeting, the Nominating and Corporate Governance Committee will act to determine whether to
accept the director&#146;s conditional resignation and will submit such recommendation for prompt consideration by the Board. The Board will act on the Nominating and Corporate Governance Committee&#146;s recommendation within ninety days following
certification of the stockholder vote. In making their decision, the Nominating and Corporate Governance Committee will evaluate the best interests of Exelixis and its stockholders and shall consider all factors and information deemed relevant. The
director who tenders his conditional resignation shall not participate in the Nominating and Corporate Governance Committee&#146;s recommendation or Board action regarding whether to accept the conditional resignation of such director. If the Board
determines not to accept the conditional resignation of a director, the Board will promptly disclose its decision-making process and decision to reject the conditional resignation in a Form <FONT STYLE="white-space:nowrap">8-K</FONT> furnished to
the Securities and Exchange Commission, or the SEC. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Set forth below is biographical information for each person nominated and each
person whose term of office as a director will continue after the Annual Meeting. Incorporated within each biography is a description of the specific experience, qualifications, attributes and skills of each director or director nominee that led our
Board to conclude that the individual should serve as a director as of the date of this Proxy Statement. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">7</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Class&nbsp;I Director Nominees</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>for Election for a Three-Year Term Expiring at the 2021 Annual Meeting </B></FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Charles Cohen, Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Chief Executive Officer, Perform Biologics, Inc.</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 1995</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 67</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Cohen should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his training as a scientist, his knowledge and experience with respect to the
biotechnology, pharmaceutical and healthcare industries, his broad leadership experience resulting from service on various boards and as a chief executive officer, and his knowledge and experience with respect to finance
matters.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Charles Cohen, Ph.D., has been a director since November 1995. Dr.&nbsp;Cohen is an independent investor and since March 2015, has served as Chief
Executive Officer and as a member of the board of directors of Perform Biologics, Inc., a private biotechnology <FONT STYLE="white-space:nowrap">start-up</FONT> company. Previously, Dr. Cohen served as Chief Executive Officer and as a member of the
board of directors of On Target Therapeutics, LLC, a private biotechnology start-up company, from June 2015 to June 2017. From May 2007 to December 2015, Dr.&nbsp;Cohen was a managing director of Synthesis Capital (formerly Advent Healthcare
Ventures), a venture capital firm. From 2003 to 2007, Dr.&nbsp;Cohen was Vice President of Advent International, a global private equity firm. From 2000 to 2002, Dr.&nbsp;Cohen was the Chief Executive Officer of Cellzome AG, a post-genomics
biotechnology company. Prior to that time, Dr.&nbsp;Cohen <FONT STYLE="white-space:nowrap">co-founded</FONT> Creative BioMolecules, Inc., a biotechnology company, in 1982 and was one of its directors and its Chief Executive Officer from 1985 to
1995. Dr.&nbsp;Cohen served as a member of the board of directors of the following publicly-held companies: Anadys Pharmaceuticals, Inc., a biopharmaceutical company dedicated to improving patient care by developing novel medicines for the treatment
of hepatitis C, from 2000 to 2005; and Anesiva, Inc., a biopharmaceutical company focused on the development and commercialization of novel pharmaceutical products for pain management from 2005 to 2007. Dr.&nbsp;Cohen also served as the Chairman of
the Supervisory Board of Cellzome AG, prior to its acquisition by GlaxoSmithKline in May 2012, and as the Chief Executive Officer of several other companies. Dr.&nbsp;Cohen received his Ph.D. from New York University School of
Medicine.</FONT></P></TD>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>George Poste, DVM, Ph.D., FRS</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Chief Scientist, Complex Adaptive Systems Initiative</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2004</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 73</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Poste should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his training as a scientist, his knowledge and experience with respect to the life
sciences, healthcare and pharmaceutical industries, his broad leadership experience resulting from service on various boards, and his knowledge and experience with policymaking, regulatory issues and other governmental matters.</FONT></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">George Poste, DVM, Ph.D., FRS, has been a director since August 2004. Since February 2009, Dr.&nbsp;Poste has been the Chief Scientist at Complex
Adaptive Systems Initiative and Regents&#146; Professor and Del E. Webb Professor of Health Innovation at Arizona State University. From May 2003 to February 2009, Dr.&nbsp;Poste served as the director of the Biodesign Institute at Arizona State
University. Dr.&nbsp;Poste has served as the Chief Executive Officer of Health Technology Networks, a consulting company that specializes in the application of genomic technologies and computing in healthcare, since 2000. From 1992 to 1999, he was
the Chief Science and Technology Officer and President, R&amp;D, of SmithKline Beecham Corporation, a pharmaceutical company. Dr.&nbsp;Poste served on the Defense Science Board of the U.S. Department of Defense from 2001 to 2010 and is a member of
other organizations dedicated to advancing defenses against bioweapons and biowarfare. Dr.&nbsp;Poste has served as a member of the board of directors of Monsanto Company, a publicly-held provider of agricultural products and solutions, since 2003,
and as a member of the board of directors of Caris Life Sciences, a privately-held medical diagnostics company, since 2009. From April 2000 until August 2009, Dr.&nbsp;Poste served as the <FONT STYLE="white-space:nowrap">Non-Executive</FONT>
Chairman of Orchid Cellmark, Inc., a publicly-held DNA forensics company. Dr.&nbsp;Poste is a Fellow of the Royal Society, the UK Academy of Medical Sciences, Hoover Institution, Stanford University, and various other prestigious organizations and
has been awarded honorary doctorates from several universities. Dr.&nbsp;Poste holds a D.V.M. in veterinary medicine and a Ph.D. in Virology from the University of Bristol, England.</FONT></P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">8</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Class I Director Nominees </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Jack L. Wyszomierski</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Former Executive Vice President and Chief Financial Officer,</B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>VWR International, LLC</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2004</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 62</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Mr.&nbsp;Wyszomierski should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his extensive financial reporting, accounting and finance experience, as well as his
experience in the healthcare and life sciences industries. These qualities have also formed the basis for the Board&#146;s decision to appoint Mr.&nbsp;Wyszomierski as a member and chairman of the Audit Committee.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Jack L. Wyszomierski, has been a director since February 2004. From June 2004 to June 2009, Mr.&nbsp;Wyszomierski served as the Executive Vice
President and Chief Financial Officer of VWR International, LLC, a supplier of laboratory supplies, equipment and supply chain solutions to the global research laboratory industry. From 1982 to 2003, Mr.&nbsp;Wyszomierski held positions of
increasing responsibility within the finance group at Schering-Plough Corporation, a health care company, culminating with his appointment as Executive Vice President and Chief Financial Officer in 1996. Prior to joining Schering-Plough, he was
responsible for capitalization planning at Joy Manufacturing Company, a producer of mining equipment, and was a management consultant at Data Resources, Inc. Mr.&nbsp;Wyszomierski has served: as a member of the board of directors of XOMA
Corporation, a publicly-held company that discovers, develops novel antibody therapeutics, since August 2010; as a member of the board of directors of Athersys, Inc., a publicly-held company engaged in the discovery and development of therapeutic
product candidates, since June 2010; as a member of the board of directors of Solenis LLC, a privately-held manufacturer of chemical products, since August 2014; and as a member of the board of directors of SiteOne Landscape Supply, Inc., a
publicly-held company that distributes landscape supply products, since April 2016. Mr.&nbsp;Wyszomierski previously served as a member of the board of directors of: Unigene Laboratories, Inc., a publicly-held biopharmaceutical company, from April
2010 to July 2013; and AssuraMed Holding, Inc., a privately-held distributor of home healthcare products, from January 2011 until its acquisition by Cardinal Health Inc. in March 2013. Mr.&nbsp;Wyszomierski holds a M.S. in Industrial Administration
and a B.S. in Administration, Management Science and Economics from Carnegie Mellon University.</FONT></P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; padding-top:0pt; font-size:12pt; font-family:arial" ALIGN="center"><FONT COLOR="#ff4c00"><B>THE BOARD OF DIRECTORS RECOMMENDS A VOTE &#147;FOR&#148; EACH NAMED NOMINEE. </B></FONT></P></div>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Class&nbsp;II Directors</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Continuing in Office Until the 2019 Annual Meeting </B></FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Carl B. Feldbaum, Esq.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>President Emeritus, Biotechnology Industry Organization</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2007</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 74</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Mr.&nbsp;Feldbaum should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his training as an attorney, his knowledge and experience with respect to the
biotechnology, pharmaceutical and healthcare industries, his broad leadership experience resulting from service on various boards and as an executive officer and his knowledge and experience with policymaking, regulatory issues and other
governmental matters.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Carl B. Feldbaum, Esq., has been a director since February 2007. Mr.&nbsp;Feldbaum serves as a member emeritus of the board of directors of BIO
Ventures for Global Health, a <FONT STYLE="white-space:nowrap">non-profit</FONT> organization, and is president emeritus of the Biotechnology Industry Organization (BIO), which represents more than 1,000 biotechnology companies, academic
institutions and state biotechnology centers internationally. Mr.&nbsp;Feldbaum served as president of BIO from 1993 until his retirement in 2005. Prior to joining BIO, Mr.&nbsp;Feldbaum was chief of staff to Senator Arlen Specter of Pennsylvania.
He also was president and founder of Palomar Corporation, a national security &#147;think tank&#148; in Washington, D.C. Before founding Palomar Corporation, Mr.&nbsp;Feldbaum was Assistant to the Secretary of Energy and served as the Inspector
General for defense intelligence in the U.S. Department of Defense. Mr.&nbsp;Feldbaum served as a member of the board of directors of the following publicly-held companies: Actelion, Ltd, a biopharmaceutical company focused on the discovery,
development and commercialization of innovative drugs for diseases with significant unmet medical needs (acquired by Johnson&nbsp;&amp; Johnson in 2017), from 2005 to 2015; Trovagene, Inc., a precision medicine biotechnology company focused on the
development of oncology therapeutics for improved cancer care, from 2014 to 2015; and Connetics Corporation, a specialty pharmaceutical company focused on the development and commercialization of innovative therapeutics for the dermatology market,
from 2005 until its acquisition by Stiefel Laboratories, Inc. in 2006. Mr.&nbsp;Feldbaum holds an A.B. in Biology from Princeton University and a J.D. from the University of Pennsylvania Law School.</FONT></P></TD>
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 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">9</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Maria C. Freire, Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>President and Executive Director, Foundation for the National Institutes of Health</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2018</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 64</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr. Freire should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to her training as a scientist, her knowledge and experience with respect to medical research, the
pharmaceutical industry and government healthcare policymaking, as well as her leadership experience in the public sector.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Maria C. Freire, Ph.D., has been a director since April 2018. Since November 2012, Dr.&nbsp;Freire has served as President and Executive Director
and as a member of the board of directors of the Foundation for the National Institutes of Health. From March 2008 to November 2012, she served as President and as a member of the board of directors of the Albert and Mary Lasker Foundation. Prior to
joining the Lasker Foundation, Dr. Freire served as President and Chief Executive Officer of the Global Alliance for TB Drug Development from 2001 to 2008 and Director of the Office of Technology Transfer at the National Institutes of Health from
1995 to 2001. Dr.&nbsp;Freire has served on the board of directors of Alexandria Real Estate Equities, Inc. a publicly-held urban office real estate investment trust uniquely focused on collaborative life science and technology campuses, since April
2012, and has served on the boards of numerous national and international organizations, including the Science Board of the U.S. Food and Drug Administration, the World Health Organization Commission on Intellectual Property Rights, Innovation and
Public Health and the United Nations Secretary General&#146;s High Level Panel on Access to Medicines. Dr.&nbsp;Freire is also a member of the National Academy of Medicine and the Council on Foreign Relations, and she is the recipient of numerous
awards, including a 2017 Gold Stevie Award for &#147;Woman of the Year,&#148; the U.S. Department of Health and Human Services Secretary&#146;s Award for Distinguished Service, the Arthur S. Fleming Award and the Bayh-Dole Award. Dr. Freire holds a
Ph.D. in Biophysics from the University of Virginia and a B.S. from the Universidad Peruana Cayetano Heredia in Lima, Peru.</FONT></P></TD>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Alan M. Garber, M.D., Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Provost of Harvard University</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2005</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 62</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Garber should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his training as a physician and economist, his knowledge and experience with respect to
the life sciences, healthcare and pharmaceutical industries, and his knowledge and experience with policymaking, regulatory issues and other governmental matters.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Alan M. Garber, M.D., Ph.D., has been a director since January 2005. He became Provost of Harvard University, Mallinckrodt Professor of Health Care
Policy at Harvard Medical School, and a Professor in the Harvard Kennedy School of Government and in the Department of Economics at Harvard in September 2011. Before moving to Harvard, from 1998 until August 2011, he was the Henry J. Kaiser Jr.
Professor, a Professor of Medicine, and a Professor (by courtesy) of Economics, Health Research and Policy, and of Economics in the Graduate School of Business at Stanford University. Dr.&nbsp;Garber also served as the Director of the Center for
Primary Care and Outcomes Research and the Center for Health Policy at Stanford. During his tenure at Stanford University, Dr.&nbsp;Garber also served as a Senior Fellow at the Freeman Spogli Institute for International Studies and as a staff
physician at the VA Palo Alto Health Care System. Dr.&nbsp;Garber has served as a member of the board of directors of Vertex Pharmaceuticals Incorporated, a publicly-held biotechnology company focused on developing and commercializing therapies for
the treatment of cystic fibrosis, since June 2017. Dr.&nbsp;Garber is a member of the National Academy of Medicine, the American Society of Clinical Investigation, the Association of American Physicians, the American Academy of Arts and Sciences and
the Board on Science, Technology, and Economic Policy at the National Academies. He is a Fellow of the American College of Physicians, the Royal College of Physicians and the American Association for the Advancement of Science. Dr.&nbsp;Garber is
also a Research Associate with the National Bureau of Economic Research and served as founding Director of its Health Care Program for nineteen years. He has also served as a member of the National Advisory Council on Aging at the National
Institutes of Health, as a member of the Board of Health Advisers of the Congressional Budget Office and as Chair of the Medicare Evidence Development and Coverage Advisory Committee at the Centers for Medicare and Medicaid Services. Dr.&nbsp;Garber
previously served on the editorial board of acclaimed scientific journals and has received numerous awards and honors. Dr.&nbsp;Garber holds an A.B. summa cum laude, an A.M. and a Ph.D., all in Economics, from Harvard University, and an M.D. with
research honors from Stanford University.</FONT></P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">10</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Proposal 1&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT
STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Class&nbsp;II Directors </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Vincent T. Marchesi, M.D., Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Professor of Pathology and Cell Biology, Yale University</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2005</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 82</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Marchesi should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his training as a physician and scientist and his research and experience in the fields
of healthcare and life sciences, with a particular focus on biotechnology.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Vincent T. Marchesi, M.D., Ph.D., has been a director since May 2001. Since 1973, Dr.&nbsp;Marchesi has been a Professor of Pathology and Cell
Biology at Yale University and, since 1991, the Director of the Boyer Center for Molecular Medicine at Yale University. In 1982, Dr.&nbsp;Marchesi <FONT STYLE="white-space:nowrap">co-founded</FONT> Molecular Diagnostics, Inc., a diagnostic
development company. Dr.&nbsp;Marchesi was formerly Chair of Pathology at the <FONT STYLE="white-space:nowrap">Yale-New</FONT> Haven Hospital. Dr.&nbsp;Marchesi holds an M.D. from Yale University and a Ph.D. from Oxford University, and is a member
of the National Academy of Sciences and the Institute of Medicine.</FONT></P> <P STYLE="font-size:24pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Julie Anne Smith</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>President and Chief Executive Officer, Nuredis, Inc.</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2016</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 47</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Ms.&nbsp;Smith should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to her knowledge and experience with respect to biotechnology, healthcare and pharmaceutical
industries and her broad leadership experience resulting from service as an executive in the pharmaceutical industry.</FONT></P></TD></TR>
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<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Julie Anne Smith, has been a director since September 2016. Since July 2017, Ms.&nbsp;Smith has served as President and Chief Executive Officer and
sits on the board of directors of Nuredis, Inc., a privately-held biotechnology company developing novel therapies to treat inherited neurodegenerative diseases caused by nucleotide repeat expansions. Previously, Ms.&nbsp;Smith served as President
and Chief Executive Officer of Raptor Pharmaceutical Corp. from January 2015 until the company&#146;s acquisition by Horizon Pharma plc in October 2016, where she also served as Executive Vice President and Chief Operating Officer from 2012 to 2014.
From 2008 to 2012, Ms.&nbsp;Smith served as Chief Commercial Officer of Enobia Pharmaceuticals prior to the company&#146;s acquisition by Alexion Pharmaceuticals, Inc. Previously, Ms.&nbsp;Smith served as Vice President of Commercial at Jazz
Pharmaceuticals from 2006 to 2008, as Vice President, Global Marketing at Genzyme General from 2001 to 2005, and helped to establish the commercial operations division for the biotech <FONT STYLE="white-space:nowrap">start-up,</FONT> Novazyme
Pharmaceuticals, from 2000 to 2001. Ms.&nbsp;Smith began her industry career at Bristol-Myers Squibb Company, joining the company in 1996 as a Product Manager and rising to become a Director of channel strategy and design. Ms.&nbsp;Smith has served
on the board of directors of Audentes Therapeutics, Inc. a publicly-held clinical stage biotechnology company focused on developing and commercializing gene therapy products for patients suffering from serious, life-threatening rare diseases caused
by single gene defects, since December 2016 and previously, Ms.&nbsp;Smith was a Director on the Health and Emerging Companies Sections of the Biotechnology Industry Organization (BIO) board. Ms.&nbsp;Smith holds a B.S. in biological and nutritional
sciences from Cornell University.</FONT></P></TD>
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</TABLE> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Class&nbsp;III Directors</B> </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Continuing in Office Until the 2020 Annual Meeting </B></FONT></P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Michael M. Morrissey, Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>President and Chief Executive Officer, Exelixis, Inc.</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 2010</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 57</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Morrissey should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his leadership role as the President and Chief Executive Officer of Exelixis. Beyond
his role as Exelixis&#146; principal executive officer, the Board also considered Dr.&nbsp;Morrissey&#146;s extensive qualifications, including his training as a scientist, his significant knowledge and experience with respect to the biotechnology,
healthcare and pharmaceutical industries, comprehensive leadership background resulting from service as an executive in the biotechnology industry, and his ability to bring historic knowledge and continuity to the Board<I>.</I></FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D., has served as a director and as Exelixis&#146; President and Chief Executive Officer since July 2010.
Dr.&nbsp;Morrissey has held positions of increasing responsibility at Exelixis since he joined the company in February 2000, including serving as President of Research and Development from January 2007 until July 2010. From 1991 to 2000,
Dr.&nbsp;Morrissey held several positions at Berlex Biosciences, last holding the position of Vice President, Discovery Research. Earlier in his career, Dr.&nbsp;Morrissey served as a Senior Scientist and Project Team Leader in Medicinal Chemistry
at CIBA-Geigy Corporation. He is the author of numerous scientific publications in medicinal chemistry and drug discovery and an inventor on 70 issued U.S. patents and 25&nbsp;additional published U.S. patent applications. Dr.&nbsp;Morrissey holds a
B.S. (Honors) in Chemistry from the University of Wisconsin and a Ph.D. in Chemistry from Harvard University.</FONT></P> <P STYLE="font-size:24pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="font-size:24pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD>
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 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">11</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Stelios Papadopoulos, Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><FONT STYLE="white-space:nowrap">Co-Founder</FONT> and Chairman of the Board, Exelixis, Inc.</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 1994</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 69</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Papadopoulos should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his training as a scientist, his knowledge and experience with respect to the
biotechnology, healthcare and pharmaceutical industries, his broad leadership experience resulting from extensive service on various boards, his knowledge and experience with respect to finance matters, and his ability to bring historic knowledge
and continuity to the Board.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Stelios Papadopoulos, Ph.D., a <FONT STYLE="white-space:nowrap">co-founder</FONT> of Exelixis, has been a director since December 1994 and the
Chairman of the Board since January 1998. Dr.&nbsp;Papadopoulos retired as Vice Chairman of Cowen&nbsp;&amp; Co., LLC in August 2006 after six years as an investment banker with the firm, where he focused on the biotechnology and pharmaceutical
sectors. Prior to joining Cowen&nbsp;&amp; Co., he spent 13 years as an investment banker at PaineWebber, Incorporated, where he was most recently Chairman of PaineWebber Development Corp., a PaineWebber subsidiary focusing on biotechnology. He
joined PaineWebber in April 1987 from Drexel Burnham Lambert, where he was a Vice President in the Equity Research Department covering the biotechnology industry. Prior to Drexel, he was a biotechnology analyst at Donaldson, Lufkin&nbsp;&amp;
Jenrette. Before coming to Wall Street in 1985, Dr.&nbsp;Papadopoulos was on the faculty of the Department of Cell Biology at New&nbsp;York University Medical Center. He continues his affiliation with New York University Medical Center as an Adjunct
Associate Professor of Cell Biology. Dr.&nbsp;Papadopoulos is a <FONT STYLE="white-space:nowrap">co-founder</FONT> of Anadys Pharmaceuticals, Inc., a publicly-held biopharmaceutical company dedicated to improving patient care by developing novel
medicines for the treatment of hepatitis C, acquired by <FONT STYLE="white-space:nowrap">Hoffmann-La</FONT> Roche Inc. in November 2011. Dr.&nbsp;Papadopoulos served as a member of the board of directors of Anadys Pharmaceuticals from 2000 to 2011
and as its chairman in 2011, prior to its acquisition. Dr.&nbsp;Papadopoulos has also served as a member of the board of directors of three other publicly-held companies: BG Medicine, Inc., a diagnostics company focused on the development and
commercialization of cardiovascular diagnostic tests, since 2003; Biogen, Inc., a biopharmaceutical company focused on the treatment of serious diseases, since 2008 and as its chairman since 2014; and Regulus Therapeutics Inc., a biopharmaceutical
company focused on the development of medicines targeting microRNAs, since 2008, and as its chairman since 2013. Dr.&nbsp;Papadopoulos was also <FONT STYLE="white-space:nowrap">co-founder</FONT> and member of the board of directors of Cellzome Inc.,
a privately-held drug discovery company acquired by GlaxoSmithKline in May 2012. In the <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">not-for-profit</FONT></FONT> sector, Dr.&nbsp;Papadopoulos is a
<FONT STYLE="white-space:nowrap">co-founder</FONT> and Chairman of Fondation Sant&eacute;, a member of the board of visitors of Duke Health, and a member of the Global Advisory Board of the Duke Institute for Health Innovation. Dr.&nbsp;Papadopoulos
holds a Ph.D. in Biophysics and an M.B.A. in Finance, both from New York University.</FONT></P></TD>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>George A. Scangos, Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Chief Executive Officer, Vir Biotechnology, Inc.</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 1996</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 69</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Scangos should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his prior leadership role as our President and Chief Executive Officer. Beyond his prior
role as our principal executive officer, the Board also considered Dr.&nbsp;Scangos&#146; extensive qualifications, including his training as a scientist, his significant knowledge and experience with respect to the biotechnology, healthcare and
pharmaceutical industries, his comprehensive leadership background resulting from service on various boards and as an executive in the biotechnology industry, and his ability to bring historic knowledge and continuity to the
Board.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">George A. Scangos, Ph.D., has been a director since October 1996. Since January 2017, Dr.&nbsp;Scangos has served as Chief Executive Officer and as
a member of the board of directors of Vir Biotechnology, Inc., a privately held biotechnology company focused on fighting infectious diseases. From July 2010 to December 2016, Dr.&nbsp;Scangos served as Chief Executive Officer and as a member of the
board of directors of Biogen Inc., a publicly-held biopharmaceutical company focused on the treatment of serious diseases. Prior to joining the Biogen organization, from October 1996 to July 2010, Dr.&nbsp;Scangos served as our President and Chief
Executive Officer. From September&nbsp;1993 to October 1996, Dr.&nbsp;Scangos served as President of Biotechnology at Bayer Corporation, a pharmaceutical company, and was responsible for research, business and process development, manufacturing,
engineering, and quality assurance. Dr.&nbsp;Scangos has served as a member of the board of directors of various publicly-held companies, including: Agilent Technologies, Inc., a global leader in life sciences, diagnostics and applied chemical
markets, since 2014; and Anadys Pharmaceuticals, Inc., a biopharmaceutical company dedicated to improving patient care by developing novel medicines for the treatment of hepatitis C, from 2003 to 2010. Dr.&nbsp;Scangos has also served as a member of
the board of directors of our former subsidiary, TaconicArtemis GmbH (previously known as Artemis Pharmaceuticals GmbH), until 2010 and Entelos, Inc. from 1997 to 2010, and he currently serves as a director of Decibel Therapeutics, Inc. and
Fondation Sant&eacute;. Dr.&nbsp;Scangos previously served as the Chair of the California Healthcare Institute (CHI), as a member of the Board of the Global Alliance for TB Drug Development, and as a member of the board of directors of BayBio.
Dr.&nbsp;Scangos is also a member of the Board of Advisors of the University of California, San Francisco School of Pharmacy, and the National Board of Advisors of the University of California, Davis School of Medicine. Dr.&nbsp;Scangos was a Jane
Coffin Childs Post-Doctoral Fellow at Yale University and a faculty member at Johns Hopkins University. Dr.&nbsp;Scangos currently holds an appointment as Adjunct Professor of Biology at Johns Hopkins University. Dr.&nbsp;Scangos holds a B.A. in
Biology from Cornell University and a Ph.D. in Microbiology from the University of Massachusetts.</FONT></P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">12</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Proposal 1&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT
STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Class&nbsp;III Directors </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Lance Willsey, M.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Founding Partner, DCF Capital</B></FONT></P></TD>
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<TD VALIGN="top" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Director since 1997</B></FONT></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Age 56</B></FONT></P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Key Qualifications and Expertise:</B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Our Board has concluded that Dr.&nbsp;Willsey should continue to serve as a director of Exelixis as of the date of this Proxy Statement due to his
skill as a physician, his knowledge and experience with respect to the life sciences and healthcare industries, and his knowledge and experience with respect to finance matters.</FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Lance Willsey, M.D., has been a director since April 1997. Dr.&nbsp;Willsey was a founding partner of DCF Capital, a hedge fund focused on investing
in the life sciences, from July 1998 to March 2002, and currently is a consultant to institutional investors in the field of oncology. Since 2000, Dr.&nbsp;Willsey has served on the Visiting Committee of the Department of Genitourinary Oncology at
the Dana-Farber Cancer Institute at Harvard Medical School. From July 1997 to July 1998, Dr.&nbsp;Willsey served on the Staff Department of Urologic Oncology at the Dana-Farber Cancer Institute. From July 1996 to July 1997, Dr.&nbsp;Willsey served
on the Staff Department of Urology at Massachusetts General Hospital at Harvard University School of Medicine, where he was a urology resident from July 1992 to July 1996. From 2000 to 2010, Dr.&nbsp;Willsey served a member of the board of directors
of Exact Sciences Corporation, a publicly-held molecular diagnostics company focused on the early detection and prevention of the deadliest forms of cancer. Dr.&nbsp;Willsey holds a B.S. in Physiology from Michigan State University and an M.S. in
Biology and an M.D., both from Wayne State University.</FONT></P></TD>
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</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Corporate Governance </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Corporate Governance Guidelines
</FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We have adopted written corporate governance guidelines, which may be viewed at <I>www.exelixis.com</I> under the caption
&#147;Investors&nbsp;&amp; Media-Corporate Governance.&#148; This document includes guidelines for determining director independence and qualifications for directors. Our Board regularly reviews, and modifies from time to time, our corporate
governance guidelines, Board committee charters and Board practices. Please note that information found on, or accessible through, our website is not a part of, and is not incorporated into, this Proxy Statement. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Code of Conduct and Ethics </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We
have adopted a Code of Conduct and Ethics that applies to all directors, officers and employees, including the principal executive officer, principal financial officer and principal accounting officer. The Code of Conduct and Ethics is posted on our
website at <I>www.exelixis.com</I> under the caption &#147;Investors&nbsp;&amp; Media-Corporate Governance.&#148; We intend to satisfy the disclosure requirement under Item&nbsp;5.05 of Form <FONT STYLE="white-space:nowrap">8-K</FONT> regarding an
amendment to, or waiver from, a provision of this Code of Conduct and Ethics by posting such information on our website, at the address and location specified above and, to the extent required by the listing standards of the Nasdaq Stock Market, by
filing a Current Report on Form <FONT STYLE="white-space:nowrap">8-K</FONT> with the SEC, disclosing such information. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Director
Independence </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We have adopted standards for director independence pursuant to Nasdaq listing standards, which require that a majority of
the members of a listed company&#146;s board of directors qualify as &#147;independent,&#148; as affirmatively determined by the board of directors. An &#147;independent director&#148; means a person other than an officer or employee of Exelixis or
one of our subsidiaries, or another individual having a relationship that, in the opinion of the Board, would interfere with the exercise of independent judgment in carrying out the responsibilities of a director. Consistent with these
considerations, after review of all relevant transactions or relationships between each director, or any of his or her family members, and Exelixis, its senior management and its independent registered public accounting firm, the Board has
affirmatively determined that Drs. Cohen, Freire, Garber, Marchesi, Papadopoulos, Poste, Scangos and Willsey, Messrs.&nbsp;Wyszomierski and Feldbaum and Ms.&nbsp;Smith, who are eleven of the twelve members of the Board, represent a majority of the
Board and are independent. Dr.&nbsp;Morrissey, our President and Chief Executive Officer, is not independent by virtue of his employment with Exelixis. In addition, the Board has also determined that: (i)&nbsp;all directors who serve on the Audit,
Compensation and Nominating and Corporate Governance Committees are independent under applicable Nasdaq listing standards; and (ii)&nbsp;all members of the Audit Committee meet the independence requirements under the Securities Exchange Act of 1934,
as amended. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Board Leadership Structure </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">The Board does not have a formal policy on whether the role of chairman and chief executive officer should be separate or combined. Our corporate governance guidelines provide that the Board will select its chairman and the chief
executive officer in the manner it considers to be in the best interests of our company. Currently, we have an independent chairman of the board separate from the chief executive officer. The Board believes this bifurcated structure provides for
sufficient </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">13</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
independent oversight of management and strong Board leadership, while allowing for the effective management of company affairs. The Board believes that if the positions of chairman and chief
executive officer are combined, the appointment of a lead independent director would be necessary for effective governance. Accordingly, our corporate governance guidelines provide that if the roles are combined, the independent directors of the
Board must appoint a lead independent director. Our corporate governance guidelines further provide that the lead independent director would: (i)&nbsp;preside at all meetings of the Board at which the chairman is not present, including executive
sessions of the independent directors; (ii)&nbsp;have the authority to call meetings of the independent directors; (iii)&nbsp;serve as the principal liaison on Board-wide issues between the independent directors and the chairman; and (iv)&nbsp;have
such other authority and duties as the Board may from time to time determine. The Board believes that this flexible approach provides it with the ability to establish a leadership structure, based upon its judgment that is in the best interests of
our company and those of our stockholders at any given time. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Role of the Board in Risk Oversight </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Management is responsible for identifying the various risks facing our company, including, without limitation, strategic, operational, financial,
regulatory and cyber-security risks that may exist from time to time. Management is also charged with the responsibility of implementing appropriate risk management policies and procedures and managing our risk exposure on a <FONT
STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">day-to-day</FONT></FONT> basis. While we do not have a formal risk oversight policy, the Board, as a whole and through its various committees, conducts the risk oversight function for our
company. In its risk oversight role, the Board evaluates whether management has reasonable controls in place to address material risks currently facing our company and those we may face in the future. The Board and its committees meet at regularly
scheduled and special meetings throughout the year at which they are presented with information regarding risks facing the company. The Board delegates certain of its risk oversight responsibilities to its various committees as follows: </FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Our Audit Committee oversees the management of risks related to financial reporting, trading in our securities, fraud, information technology and cyber-security, including a regular review of the
existence or status of any such risks and evaluating the steps management has taken or proposes to take to mitigate them. Our Audit Committee also reviews any proposed related party transactions to ensure we do not engage in transactions that would
create a conflict of interest or result in harm to us. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Our Compensation Committee oversees the management of risks related to our compensation policies and practices, including structuring and reviewing our executive compensation programs, considering
whether such programs are in line with our strategic objectives and incentivizing appropriate risk-taking. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Our Nominating and Corporate Governance Committee oversees the management of risks related to our compliance programs, including healthcare compliance, and corporate governance matters, including
director independence and Board composition and succession. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Also, the Board is presented with frequent business updates
during monthly teleconferences among our Board and senior management. Following consideration of the information provided by management, the Board provides feedback, makes recommendations and, as needed, issues directives to management to address
our risk exposure. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Prohibitions on Derivative, Hedging, Monetization and Other Transactions </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We maintain an insider trading policy that applies to directors and employees, including our executive officers, which prohibits certain
transactions in our stock, including short sales, puts, calls or other transactions involving derivative securities, hedging or monetization transactions, purchases of Exelixis securities on margin or borrowing against an account in which Exelixis
securities are held, or pledging Exelixis stock as collateral for a loan. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Stockholder Communications with the Board </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Security holders may send communications to the Board by mail at 210 East Grand Avenue, South San Francisco, California 94080, by facsimile at <FONT
STYLE="white-space:nowrap">(650)&nbsp;837-7951</FONT> or by <FONT STYLE="white-space:nowrap">e-mail</FONT> at info@exelixis.com, each of the foregoing sent &#147;Attn: Board of Directors.&#148; </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Stock Ownership Guidelines </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In
February 2018, the Board adopted Stock Ownership Guidelines applicable to our directors and Named Executive Officers (as defined below) to further align their financial interests with those of our stockholders, as well as to promote sound
</FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">14</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Proposal 1&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT
STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Corporate Governance </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">corporate governance. For our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors, our Stock Ownership Guidelines provide an ownership target equal to the lesser of 3,000 shares or a value equivalent to three times the
annual cash Board retainer. Under the guidelines, we expect <FONT STYLE="white-space:nowrap">non-employee</FONT> directors to achieve their stock ownership targets within five years of becoming subject to these guidelines. The policy includes
procedures for granting exemptions in the case of severe financial hardship. Ownership targets for our Named Executive Officers (including those serving on our Board) are described below under<I>&nbsp;Compensation Discussion and Analysis&#151;Other
Compensation Information&#151;Stock Ownership Guidelines.</I> </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In determining ownership levels for each
<FONT STYLE="white-space:nowrap">non-employee</FONT> director under our Stock Ownership Guidelines, credit is provided for shares held outright (including shares owned through trusts, the Amended and Restated Exelixis, Inc. 401(k) Plan, or the
401(k) Plan, or by a spouse), as well as 50% of the number of vested, but unexercised, stock options. No credit is provided for restricted stock units until they vest. The values for all shares determined to be held by our <FONT
STYLE="white-space:nowrap">non-employee</FONT> directors and Named Executive Officers are based on the <FONT STYLE="white-space:nowrap">200-day</FONT> average stock price as of the measurement date. As of February&nbsp;15, 2018, the date the Board
adopted the Stock Ownership Guidelines, all of our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors serving on the Board as of such date had met the required ownership targets. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Board Committees and Meetings </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Board held five meetings during
2017 and all of our directors attended at least 75% of the total meetings of the Board and of the committees on which they served. The independent directors met four times in regularly scheduled executive sessions. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">During 2017, the Board had four standing committees: an Audit Committee, Compensation Committee, Nominating and Corporate Governance Committee and
Research&nbsp;&amp; Development Committee. Committee membership in 2017 was as follows: </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD></TR>
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<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Board Member</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f"><B>Audit<BR>Committee</B></FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Compensation</B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Committee</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f"><B>Nominating<BR>and&nbsp;Corporate<BR>Governance<BR>Committee</B></FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" BGCOLOR="#e5e5e5">
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Research&nbsp;&amp;</B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT
 COLOR="#3f3f3f"><B>Development<BR>Committee</B></FONT></P></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Charles Cohen, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Chair</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Carl B. Feldbaum, Esq.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Maria C. Freire, Ph.D.*</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Alan M. Garber, M.D., Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Chair</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Vincent T. Marchesi, M.D.,
Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Stelios Papadopoulos, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">George Poste, D.V.M., Ph.D.,
FRS</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Chair</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">George A. Scangos, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member**</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Julie A. Smith</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Lance Willsey, M.D.</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jack L. Wyszomierski</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Chair***</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Member</FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #999999"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Number of Meetings Held in Fiscal
2017</FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#ff4c00"><B>4</B></FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#ff4c00"><B>12</B></FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#ff4c00"><B>3</B></FONT></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-LEFT:1px solid #f2f2f2; BORDER-BOTTOM:1px solid #999999">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1px solid #999999" BGCOLOR="#e5e5e5"><FONT COLOR="#ff4c00"><B>2</B></FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Dr. Freire became a director on April 5, 2018 and did not serve on any committee of the Board during 2017. Dr. Freire was also appointed to the Nominating and Corporate Governance Committee and the
Research &amp; Development Committee on April 5, 2018. </FONT></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">**</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">On May&nbsp;9, 2017, Dr.&nbsp;Scangos resigned from the Audit Committee. </FONT></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">***</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Designated by the Board as an &#147;audit committee financial expert.&#148; </FONT></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT
 COLOR="#ff4c00">Audit Committee </FONT></P> <P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f">&nbsp;</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">The Audit Committee of the Board oversees our corporate accounting and financial reporting process, ensures the integrity of our financial statements and has been designated as the Qualified Legal Compliance Committee within the
meaning of Rule 205.2(k) of Title 17, Chapter II of the Code of Federal Regulations. The Audit Committee performs several functions, such as evaluating the performance of, and assessing the qualifications of, the independent registered public
accounting firm; determining whether to retain or terminate the existing independent registered public accounting firm or to appoint and </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">15</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
engage a new independent registered public accounting firm; reviewing and approving the engagement of the independent registered public accounting firm to perform any proposed permissible
services and appropriate compensation thereof; reviewing, providing oversight of, and approving related party transactions; establishing procedures, as required under applicable law, for the receipt, retention and treatment of complaints received by
Exelixis regarding accounting, internal accounting controls or auditing matters and the confidential and anonymous submission by employees of concerns regarding questionable accounting or auditing matters; overseeing our risk assessment and risk
management processes with respect to financial reporting fraud, including receiving reports on a quarterly basis concerning the existence or status of any significant financial reporting or fraud risks and discussing and evaluating the steps
management has taken or proposes to take to mitigate such risks; reviewing our tax strategy, the status of any material tax audits and proceedings and any other material tax matters; reviewing the financial statements to be included in our Annual
Report on Form <FONT STYLE="white-space:nowrap">10-K;</FONT> discussing with management and the independent registered public accounting firm the results of the annual audit and the results of our quarterly financial statement reviews; and resolving
any disagreements between the independent registered public accounting firm and management. The Audit Committee also has the specific responsibilities and authority necessary to comply with the listing standards of the Nasdaq Stock Market applicable
to audit committees. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Board has determined that Mr.&nbsp;Wyszomierski is an &#147;audit committee financial expert&#148; as defined
in applicable SEC rules. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Audit Committee&#146;s report is set forth in &#147;Report of the Audit Committee&#148; below. The Audit
Committee has a written charter, which is available on our website at <I>www.exelixis.com</I> under the caption &#147;Investors&nbsp;&amp; Media-Corporate Governance.&#148; </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Compensation Committee </FONT></P> <P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f">&nbsp;</P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The purpose of the Compensation Committee is to: oversee our compensation policies, plans and programs; review and determine the compensation to be
paid to officers and directors; work with management to address any conflict of interest with any compensation adviser engaged by management or the Compensation Committee; review with management our Compensation Discussion and Analysis, and to
consider whether to recommend that it be included in our proxy statements and other filings; and prepare and review the Compensation Committee&#146;s report included in our annual proxy statement or Annual Report on Form <FONT
STYLE="white-space:nowrap">10-K,</FONT> as applicable, in accordance with applicable rules and regulations of the SEC. The Compensation Committee also establishes and reviews general policies relating to compensation and benefits of employees,
including executive officers, and performs such other functions regarding compensation as the Board may delegate. The Compensation Committee also administers the issuance of stock options and other awards under our stock plans. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee&#146;s report is set forth in &#147;Compensation Committee Report&#148; below. Information on the Compensation
Committee&#146;s processes and procedures for consideration of executive compensation are addressed in &#147;Compensation Discussion and Analysis&#148; below. For information regarding our processes and procedures for the consideration and
determination of director compensation, please see &#147;Compensation of Directors&#148; below. The Compensation Committee has a written charter, which is available on our website at <I>www.exelixis.com</I> under the caption
&#147;Investors&nbsp;&amp; Media-Corporate Governance.&#148; </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>Compensation Consultants. </I>The Compensation Committee retained
Compensia, Inc., or Compensia, a national compensation consulting firm, as its external compensation consultant to assist the Compensation Committee in its duties related to executive and <FONT STYLE="white-space:nowrap">non-employee</FONT> director
compensation. Compensia did not perform any work for us other than the executive compensation and <FONT STYLE="white-space:nowrap">non-employee</FONT> director compensation consulting services provided to the Compensation Committee and reported
directly to the Compensation Committee or through its chairperson. Fees paid to Compensia in 2017 did not exceed $120,000. At the direction of the Compensation Committee, management retained Radford, a compensation consulting firm serving technology
and life sciences companies, principally to provide benchmark and industry compensation data for executive and broad-based compensation analyses. In consideration for compensation related services provided during 2017 we paid Radford an aggregate of
$49,587. Radford also provided our management with access to the Radford Global Life Sciences Survey, Radford Global Sales Survey and Radford U.S. Benefits Survey, for which we paid Radford an aggregate of $13,123 in 2017. Radford is an Aon Hewitt
company and an affiliate of Aon Risk Services which provided insurance brokerage services to us during 2017 at a total cost of $239,417. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT
 COLOR="#ff4c00">Nominating and Corporate Governance Committee </FONT></P> <P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f">&nbsp;</P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The purpose of the Nominating and Corporate Governance Committee is to: oversee all aspects of our corporate governance functions on behalf of the
Board; make recommendations to the Board regarding corporate governance issues; identify, </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">16</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right">Proposal
1&nbsp;<FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial">&nbsp;Board Committees and Meetings </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">review and evaluate candidates to serve as directors; serve as a focal point for communication between such candidates, <FONT
STYLE="white-space:nowrap">non-committee</FONT> directors and management; recommend such candidates to the Board and make such other recommendations to the Board regarding affairs relating to the directors; and develop a set of corporate governance
principles for Exelixis. The Nominating and Corporate Governance Committee also oversees our compliance programs, including our healthcare compliance program created to prevent fraud and abuse in federal healthcare programs and <FONT
STYLE="white-space:nowrap">non-compliance</FONT> with applicable U.S. Food and Drug Administration and other healthcare laws. The Nominating and Corporate Governance Committee has a written charter, which is available on our website at
<I>www.exelixis.com</I> under the caption &#147;Investors&nbsp;&amp; Media-Corporate Governance.&#148; </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>Director Qualifications;
Diversity. </I>The Nominating and Corporate Governance Committee does not have a fixed set of minimum qualifications for candidates for membership on the Board. Instead, in considering candidates for directorship, the Nominating and Corporate
Governance Committee will generally consider all relevant factors, including the candidate&#146;s applicable expertise and demonstrated excellence in his or her field, the usefulness of such expertise to us, the availability of the candidate to
devote sufficient time and attention to the affairs of Exelixis, the existence of any relationship that would interfere with the exercise of the candidate&#146;s independent judgment, and the candidate&#146;s demonstrated character and judgment. In
the review process, the Nominating and Corporate Governance Committee evaluates prospective candidates for directorship in the context of the existing membership of the Board (including the qualities and skills of the existing directors), our
operating requirements and the long-term interests of our stockholders. While the Board does not have a formal policy with regard to the consideration of diversity in identifying director nominees, the Nominating and Corporate Governance Committee
believes that the factors considered above enable it to identify director candidates that possess key industry knowledge as well as a variety of different professional and personal backgrounds, attributes (including, but not limited to, gender and
national origin), experiences, skills and expertise such that the Board, as a group, can best fulfill its responsibilities to our stockholders. The Nominating and Corporate Governance Committee is authorized to access external resources as it deems
necessary or appropriate to fulfill its defined responsibilities, including engagement of executive search firms to help identify director candidates. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f"><I>Director Nominations. </I>The Nominating and Corporate Governance Committee considers and assesses all candidates recommended by our directors, officers and stockholders. Evaluations of candidates generally involve a review of
background materials, internal discussions and interviews with selected candidates as appropriate. If, after its review, the Nominating and Corporate Governance Committee supports a candidate, it would recommend the candidate for consideration by
the full Board. The Nominating and Corporate Governance Committee considers stockholder recommendations for directors using the same criteria as potential nominees recommended by the members of the Nominating and Corporate Governance Committee or
others. The Nominating and Corporate Governance Committee has not received any recommended nominations from any stockholder holding 5% or more of our common stock in connection with the 2018 Annual Meeting. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Stockholders who wish to recommend individuals for consideration by the Nominating and Corporate Governance Committee to become nominees for
election to the Board may do so by delivering a written recommendation to the Nominating and Corporate Governance Committee within the timeframe specified in our Bylaws that is applicable to matters to be brought before an Annual Meeting of
Stockholders as set forth under &#147;Questions and Answers About These Proxy Materials and Voting&#148; above. Such communications should be sent to the following address: Exelixis, Inc., 210 East Grand Ave., South San Francisco, California 94080,
Attn: Nominating and Corporate Governance Committee of the Board. Submissions must include (a)&nbsp;the name, age, business address and residence address of such person, (b)&nbsp;the principal occupation or employment of such person, (c)&nbsp;the
class and number of shares of the corporation which are beneficially owned by such person, (d)&nbsp;a description of all arrangements or understandings between the stockholder and each nominee and any other person or persons (naming such person or
persons) pursuant to which the nominations are to be made by the stockholder, (e)&nbsp;a statement whether such person, if elected, intends to comply with the corporation&#146;s Corporate Governance Guidelines, including with respect to matters
relating to the election of directors, and (f)&nbsp;any other information relating to such person that is required to be disclosed in solicitations of proxies for election of directors, or is otherwise required, in each case pursuant to
Regulation&nbsp;14A under the 1934 Act (including without limitation such person&#146;s written consent to being named in the proxy statement, if any, as a nominee and to serving as a director if elected). </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Research&nbsp;&amp; Development Committee </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #3f3f3f">&nbsp;</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Research&nbsp;&amp; Development
Committee, which was established in January 2006, is responsible for advising Exelixis and the Board on matters of scientific importance as the Board, in consultation with management, may designate from time to time. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">17</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Annual Meeting; Attendance </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Board does not have a formal
policy with respect to the attendance of its members at Annual Meetings of Stockholders. Dr.&nbsp;Morrissey was the only member of the Board in attendance at the 2017 Annual Meeting of Stockholders. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">18</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Directors </FONT></P>
<p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">COMPENSATION OF DIRECTORS </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The compensation program for our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors is intended to be competitive and fair so that we
can attract optimal talent to our Board and recognize the time and effort required of a director given the size and complexity of our operations. In accordance with its charter, our Compensation Committee is responsible for recommending to the Board
for approval the annual compensation for our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors and acts on behalf of the Board in discharging the Board&#146;s responsibilities with respect to overseeing our compensation policies for <FONT
STYLE="white-space:nowrap">non-employee</FONT> directors. In February 2017, the Board approved changes to the <FONT STYLE="white-space:nowrap">non-employee</FONT> director compensation program following consideration of market data prepared by the
Compensation Committee&#146;s independent compensation adviser, Compensia, and the recommendation of the Compensation Committee. All changes were effective beginning with the first quarter of fiscal 2017. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Cash Compensation Arrangements </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Each <FONT STYLE="white-space:nowrap">non-employee</FONT> director receives an annual cash retainer for his or her service on the Board, as well as an annual cash retainer if he or she serves as the Chairman of the Board, on a
committee or as the chair of a committee. In addition, our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors receive fees for attendance at Board meetings and at their respective committee meetings. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The table below provides information regarding the cash compensation arrangements for our <FONT STYLE="white-space:nowrap">non-employee</FONT>
directors for 2017. Dr.&nbsp;Morrissey receives no compensation in his capacity as a member of the Board. </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="50%"></TD>
<TD VALIGN="bottom" WIDTH="6%"></TD>
<TD WIDTH="30%"></TD>
<TD VALIGN="bottom" WIDTH="7%"></TD>
<TD style="width:41pt"></TD>
<TD></TD>
<TD></TD>
<TD style="width:41pt"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#ff4c00"><B>Service</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#ff4c00"><B>Fee Type</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="4" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00">
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#ff4c00"><B>Cash&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#ff4c00"><B>Compensation&nbsp;($)&nbsp;&nbsp;&nbsp;&nbsp;</B></FONT></P></TD></TR>


<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Board</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">25,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Additional&nbsp;Chair&nbsp;Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">30,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Regular Meeting Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2,500&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Special Meeting&nbsp;Fee (1)</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Audit Committee</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">6,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Additional&nbsp;Chair&nbsp;Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">15,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Meeting Fee (2)</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Compensation Committee</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">5,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Additional&nbsp;Chair&nbsp;Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Meeting Fee (2)</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Nominating&nbsp;&amp; Corporate Governance Committee</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">5,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Additional&nbsp;Chair&nbsp;Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Meeting Fee (2)</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Research&nbsp;&amp; Development Committee</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Additional&nbsp;Chair&nbsp;Retainer&nbsp;Fee</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" >&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom"></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">Meeting Fee (2)</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00;">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">5,000&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Meeting at which minutes are generated. </FONT></TD></TR></TABLE>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f"><FONT STYLE="white-space:nowrap">In-person</FONT> meeting or teleconference at which minutes are generated. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Equity Compensation Arrangements </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors are also eligible to receive equity as part of their Board service, including an initial award upon joining the Board and an annual award on the day following each
Annual Meeting of Stockholders. Grants to our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors are made under our 2017 Equity Incentive Plan, or 2017 Plan, pursuant to the <FONT STYLE="white-space:nowrap">Non-Employee</FONT> Director
Equity Compensation Policy, or 2017 Directors&#146; Policy, as adopted by the Board.&nbsp;Historically, our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors would receive initial awards and annual awards in the form of an option to
purchase a specific and <FONT STYLE="white-space:nowrap">pre-determined</FONT> number of shares of our common stock. However, to address continued changes in the trading price of our common stock, the 2017 Directors&#146; Policy moved to a
value-based approach for determining the number of shares subject to these equity awards. During 2017, under the terms of the 2017 Directors&#146; Policy, <FONT STYLE="white-space:nowrap">non-employee</FONT> directors were eligible to receive a <FONT
STYLE="white-space:nowrap">one-time</FONT> initial award having a value equal to approximately $400,000 when they first join the Board and an annual award having a value equal to approximately $250,000 on the day following each Annual Meeting of
Stockholders. Each initial </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">19</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
award and annual award will be divided between approximately 50% in the form of a nonstatutory stock option and approximately 50% in the form of an RSU award, based on a valuation methodology
established by the Board; provided, however, that with respect to annual awards, each <FONT STYLE="white-space:nowrap">non-employee</FONT> director may instead elect to receive 100% of such equity grants in the form of a nonstatutory stock option.
The total number of options and RSUs granted as part of the initial award and each annual award is determined using a formula based upon the Black-Scholes Merton option pricing model and the average of the daily closing sale prices of our common
stock for all of the trading days during the <FONT STYLE="white-space:nowrap">30-day</FONT> calendar period ending on (and including) the last calendar day immediately prior to the grant date of such initial award or annual award. The fair value of
such initial award or annual award, as determined in accordance with the 2017 Directors&#146; Policy, may be greater or lesser than the grant date fair value reflected in the &#147;Director Compensation Table&#148; below. This is a result of the
different calculation employed to determine the grant date fair value of each initial award or annual award, which is determined using a formula based upon the Black-Scholes Merton option pricing model and the closing sale price of our common stock
on the grant date. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Options granted under the 2017 Plan in accordance with the 2017 Directors&#146; Policy are not incentive stock
options under the Internal Revenue Code of 1986, as amended, or the Code. The exercise price of automatic grants of stock options under the 2017 Plan is equal to 100% of the fair market value of a share of common stock on the grant date. Under the
terms of the 2017 Directors&#146; Policy, the <FONT STYLE="white-space:nowrap">one-time</FONT> initial options are immediately exercisable but are subject to a repurchase right and will vest at the rate of 25% of the underlying shares on the first
anniversary of the grant date and monthly thereafter over the next three years. The annual options are exercisable immediately but are subject to a repurchase right and will vest monthly in equal parts over a
<FONT STYLE="white-space:nowrap">one-year</FONT> period. As long as the <FONT STYLE="white-space:nowrap">non-employee</FONT> director continues to serve with us or with an affiliate of us, the option will continue to vest and be exercisable during
its term. When the option holder&#146;s service terminates, we will have the right to repurchase any unvested shares acquired upon exercise of the option at the original exercise price without interest. The post-termination exercise period for the
vested portion of the options granted to our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors is generally set to terminate the earlier of three years after a <FONT STYLE="white-space:nowrap">non-employee</FONT> director&#146;s service
terminates or the remainder of the term of the option, as described in the form of option agreement for <FONT STYLE="white-space:nowrap">non-employee</FONT> directors under the 2017 Plan. The options granted pursuant to the 2017 Directors&#146;
Policy have a term that does not exceed seven years. Under the terms of the 2017 Directors&#146; Policy, the <FONT STYLE="white-space:nowrap">one-time</FONT> initial RSU awards will vest at the rate of 25% of the underlying shares on each of the
first four anniversaries of the grant date, so long as the <FONT STYLE="white-space:nowrap">non-employee</FONT> director continues to serve with us or with an affiliate with us. The annual RSU awards will vest at the rate of 100% of the shares on
the first anniversary of the grant date, so long as the <FONT STYLE="white-space:nowrap">non-employee</FONT> director continues to serve with us or with an affiliate with us. In the event of a change in control, 100% of the <FONT
STYLE="white-space:nowrap">non-employee</FONT> director&#146;s outstanding and unvested equity awards will immediately vest, and any applicable repurchase rights of the Company will terminate. In the event of a change in control, the vesting of each
award granted under the 2017 Directors&#146; Plan (or under our prior <FONT STYLE="white-space:nowrap">Non-Employee</FONT> Director Equity Compensation Policy, or the Prior Directors&#146; Policy, under the 2014 Equity Incentive Plan, or the 2014
Plan) will be accelerated in full to a date prior to the effective time of such change in control (contingent upon the effectiveness of such change in control) as the Board will determine (or, if the Board does not determine such a date, to the date
that is five days prior to the effective time of such change in control). </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">On September&nbsp;22, 2016, Ms.&nbsp;Smith Joined the Board
and became eligible to receive an equity award pursuant to the terms of the Prior Directors&#146; Policy. At the time Ms.&nbsp;Smith joined the Board, the Compensation Policy determined that it would be appropriate to grant Ms.&nbsp;Smith an initial
option award having a value equal to approximately $200,000, which reflected the value of an initial option award at the time of the most recent Board compensation analysis prior to Ms.&nbsp;Smith joining the Board. Accordingly, the Board granted
Ms.&nbsp;Smith an option to purchase 26,000 shares of our common stock as her <FONT STYLE="white-space:nowrap">one-time</FONT> initial option award. However, on February&nbsp;23, 2017, in connection with the Board&#146;s adoption of the 2017
Directors&#146; Policy and the increase in the target value of the <FONT STYLE="white-space:nowrap">one-time</FONT> initial awards to $400,000, the Board granted Ms.&nbsp;Smith a supplemental award in the form of an option to purchase an additional
16,620 shares of our common stock, such that the total value of both her initial award and supplemental award was equal to approximately $400,000. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f"><B>Reimbursement of Expenses </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The members of the Board are eligible for reimbursement of certain expenses incurred
in connection with their attendance of Board meetings and their service on the Board in accordance with our policy. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">20</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Directors </FONT></P>
<p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Director Compensation Table </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table shows compensation
information for our <FONT STYLE="white-space:nowrap">non-employee</FONT> directors for the fiscal year ended December&nbsp;29, 2017. Discussion of Dr. Freire&#146;s compensation is not included, as she did not become a director until April 5, 2018.
</FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Director Compensation for Fiscal 2017 </B></FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="51%"></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Fees&nbsp;Earned&nbsp;or<BR>Paid&nbsp;in&nbsp;Cash<BR>($)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Stock&nbsp;Awards<BR>(Restricted&nbsp;Stock<BR>Units)&nbsp;($)(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option&nbsp;Awards<BR>($)(2)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Total</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Charles Cohen, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">94,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">233,501</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">328,001</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Carl B. Feldbaum, Esq.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">61,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">233,501</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">295,001</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Alan M. Garber, M.D., Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">74,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">233,501</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">308,001</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Vincent T. Marchesi, M.D.,
Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">74,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">114,348</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">116,159</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">305,007</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Stelios Papadopoulos, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">97,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">114,348</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">116,159</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">328,007</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">George Poste, D.V.M., Ph.D.,
FRS</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">75,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">114,348</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">116,159</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">306,007</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">George A. Scangos, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">62,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">233,501</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">296,001</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Julie A. Smith</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">61,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">426,844</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(3)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">488,344</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Lance Willsey, M.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">74,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">233,501</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">308,001</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jack L. Wyszomierski</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">70,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">114,348</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">116,159</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">301,007</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">On May&nbsp;25, 2017, each of Drs. Marchesi, Papadopoulos and Poste and Mr.&nbsp;Wyszomierski were granted an RSU award pursuant to the 2017 Directors&#146; Policy, which accounted for
approximately 50% of the total value of their annual award. Amounts shown in this column reflect the grant date fair value of the RSU award as computed in accordance with Financial Accounting Standards Board, or FASB, Accounting Standards
Codification Topic 718, or ASC 718. The assumptions used to calculate the value of RSUs are set forth in Note 8 of the Notes to Consolidated Financial Statements included in our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for
the fiscal year ended December&nbsp;27, 2017, filed with the SEC on February&nbsp;26, 2018. See &#147;Equity Compensation Arrangements&#148; above for a description of the RSU awards made to <FONT STYLE="white-space:nowrap">non-employee</FONT>
directors on May&nbsp;25, 2017. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Only one RSU award was granted to each of Drs. Marchesi, Papadopoulos and Poste and Mr.&nbsp;Wyszomierski during fiscal 2017 and, accordingly, the grant date fair value of that RSU award is
reflected in the table. The aggregate number of shares subject to all RSUs held by each of these <FONT STYLE="white-space:nowrap">non-employee</FONT> directors as of December&nbsp;29, 2017, is as follows: Dr.&nbsp;Marchesi&#151;5,843;
Dr.&nbsp;Papadopoulos&#151;5,843; Dr.&nbsp;Poste&#151;5,843; and Mr.&nbsp;Wyszomierski&#151;5,843. None of the other <FONT STYLE="white-space:nowrap">non-employee</FONT> directors received any RSU awards during fiscal 2017, and none of the other <FONT
STYLE="white-space:nowrap">non-employee</FONT> directors held any outstanding RSU awards as of December&nbsp;29, 2017. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">On May&nbsp;25, 2017, each <FONT STYLE="white-space:nowrap">non-employee</FONT> director was granted an option to purchase our common stock pursuant to the 2017 Directors&#146; Policy. Each of Drs.
Cohen, Garber, Scangos and Willsey, Mr.&nbsp;Feldbaum and Ms.&nbsp;Smith elected to receive 100% of their annual award in the form of options to purchase our common stock, while each of Drs. Marchesi, Papadopoulos and Poste and Mr.&nbsp;Wyszomierski
elected to receive approximately 50% of their annual award in the form of options to purchase our common stock and approximately 50% of their annual award in the form of an RSU award. Amounts shown in this column reflect the aggregate grant date
fair value for the option awards granted in fiscal 2017 as computed in accordance with FASB ASC 718. The assumptions used to calculate the value of option awards are set forth in Note 8 of the Notes to Consolidated Financial Statements included in
our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, filed with the SEC on February&nbsp;26, 2018. See &#147;Equity Compensation Arrangements&#148; above for a description of the
option grants made to <FONT STYLE="white-space:nowrap">non-employee</FONT> directors on May&nbsp;25, 2017. There can be no assurance that the options will ever be exercised (in which case no value will actually be realized by the director) or that
the value on exercise of stock options will be equal to the grant date fair value shown in this column. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">With the exception of Ms.&nbsp;Smith, who was also granted a supplemental option award on February&nbsp;23, 2017, only one stock option award was granted to each
<FONT STYLE="white-space:nowrap">non-employee</FONT> director during fiscal 2017 and, accordingly, the grant date fair value of that stock option is reflected in the table. The aggregate number of shares subject to all stock options held by each of
our current <FONT STYLE="white-space:nowrap">non-employee</FONT> directors as of December&nbsp;29, 2017, is as follows: Dr.&nbsp;Cohen&#151;360,137; Mr.&nbsp;Feldbaum&#151;269,287; Dr.&nbsp;Garber&#151;301,697; Dr.&nbsp;Marchesi&#151;272,940;
Dr.&nbsp;Papadopoulos&#151;353,727; Dr.&nbsp;Poste&#151;226,348; Dr.&nbsp;Scangos&#151;333,510; Ms.&nbsp;Smith&#151;66,111; Dr.&nbsp;Willsey&#151;350,883; and Mr.&nbsp;Wyszomierski&#151;295,339. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">21</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">

<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">On February&nbsp;23, 2017, Ms.&nbsp;Smith was granted a supplemental award in the form of an option to purchase 16,620 shares or our common stock in connection with the Board&#146;s adoption of the
2017 Directors&#146; Policy and the increase in the target value of the <FONT STYLE="white-space:nowrap">one-time</FONT> initial awards to $400,000. The grant date fair value of her supplemental award was $193,343 and the grant date fair value of
her annual award was $233,501, in each case as computed in accordance with FASB ASC 718. The assumptions used to calculate the value of this option award is set forth in Note 8 of the Notes to Consolidated Financial Statements included in our Annual
Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, filed with the SEC on February&nbsp;26, 2018. See &#147;Equity Compensation Arrangements&#148; above for a description of the supplemental
option grant made to Ms.&nbsp;Smith on February&nbsp;23, 2018. There can be no assurance that the option will ever be exercised (in which case no value will actually be realized by the director) or that the value on exercise of the stock option will
be equal to the grant date fair value described above. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">22</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

</DIV></Center>


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<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Proposal 2 &nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT
STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Ratification of Selection of Independent Registered Public Accounting Firm </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">P<SMALL>ROPOSAL</SMALL> 2 </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#6d6d6d">R<SMALL>ATIFICATION</SMALL> <SMALL>OF</SMALL> S<SMALL>ELECTION</SMALL> <SMALL>OF</SMALL> I<SMALL>NDEPENDENT</SMALL> R<SMALL>EGISTERED</SMALL>
P<SMALL>UBLIC</SMALL> A<SMALL>CCOUNTING</SMALL> F<SMALL>IRM</SMALL> </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Audit Committee of the Board has selected Ernst&nbsp;&amp;
Young LLP as Exelixis&#146; independent registered public accounting firm for the fiscal year ending December&nbsp;28, 2018. The Board, on behalf of the Audit Committee, has further directed that management submit the selection of the independent
registered public accounting firm for ratification by the stockholders at the Annual Meeting. Ernst&nbsp;&amp; Young LLP has audited our financial statements for each of the seventeen fiscal years in the period ended December&nbsp;29, 2017.
Representatives of Ernst&nbsp;&amp; Young LLP are expected to be present at the Annual Meeting. They will have an opportunity to make a statement if they so desire and will be available to respond to appropriate questions. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Neither our Bylaws nor other governing documents or law require stockholder ratification of the selection of Ernst&nbsp;&amp; Young LLP as
Exelixis&#146; independent registered public accounting firm. However, the Board is submitting the selection of Ernst&nbsp;&amp; Young LLP to the stockholders for ratification as a matter of good corporate governance. If the stockholders fail to
ratify the selection, the Audit Committee of the Board will reconsider whether or not to retain that firm. Even if the selection is ratified, the Audit Committee of the Board in its discretion may direct the appointment of a different independent
registered public accounting firm at any time during the year if they determine that such a change would be in the best interests of Exelixis and its stockholders. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The affirmative vote of the holders of a majority of the shares present in person or represented by proxy and entitled to vote at the Annual
Meeting is required to ratify the selection of Ernst&nbsp;&amp; Young LLP. Abstentions will be counted toward the tabulation of votes cast on proposals presented to the stockholders and will have the same effect as a vote against this proposal.
Broker <FONT STYLE="white-space:nowrap">non-votes,</FONT> if any, will have no effect on the results of this vote. </FONT></P>
<P STYLE="font-size:24pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><div style="max-width:100%;margin-left:0%; margin-right:0%;background-color:#e5e5e5;;padding-top:2pt;padding-bottom:3pt">
<P STYLE="margin-top:0pt; margin-bottom:0pt; padding-top:0pt; font-size:12pt; font-family:arial" ALIGN="center"><FONT COLOR="#ff4c00"><B>THE BOARD OF DIRECTORS RECOMMENDS A VOTE &#147;FOR&#148; PROPOSAL 2. </B></FONT></P></div>
<P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Principal Accountant Fees and Services </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">The aggregate fees billed by Ernst&nbsp;&amp; Young LLP for the last two fiscal years for the services described below are as follows: </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="78%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Fiscal Year Ended</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="center"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">December&nbsp;29,</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">2017</FONT></B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">December&nbsp;30,<BR>2016</FONT></B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-RIGHT:1px solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-right:2pt">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Audit Fees<SUP
STYLE="font-size:85%; vertical-align:top"> (1)</SUP></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,658,395</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,703,009</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Audit-Related Fees<SUP
STYLE="font-size:85%; vertical-align:top"> (2)</SUP></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">220,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Tax Fees <SUP
STYLE="font-size:85%; vertical-align:top">(3)</SUP></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">208,152</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">All Other Fees <SUP
STYLE="font-size:85%; vertical-align:top">(4)</SUP></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,955</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,995</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>&nbsp;&nbsp;&nbsp;&nbsp;Total
Fees</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>$</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>2,088,502</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B></B>&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>$</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>1,705,004</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B></B>&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;Audit fees&#148; consist of fees billed for professional services rendered for the audit of our consolidated financial statements and review of the interim consolidated financial statements
included in quarterly reports and services that are normally provided by Ernst&nbsp;&amp; Young LLP in connection with statutory and regulatory filings and other engagements such as comfort letters, consents, and review of documents filed with the
SEC. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;Audit-related fees&#148; consist of fees billed for assurance and related services that are reasonably related to the performance of the audit or review of our consolidated financial
statements and are not reported under &#147;Audit fees.&#148; During fiscal 2017 these services included consultations relating to various transactions. We did not incur any &#147;Audit-related&#148; fees during fiscal 2016.
</FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;Tax fees&#148; include fees for tax compliance, tax advice and tax planning. No tax fees were billed during fiscal 2016. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">23</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(4)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;All other fees&#148; consist of fees for products and services other than the services described above. During fiscal 2017 and 2016, these fees related to an
<FONT STYLE="white-space:nowrap">on-line</FONT> subscription to an Ernst&nbsp;&amp; Young, LLP database. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">All fees
described above were <FONT STYLE="white-space:nowrap">pre-approved</FONT> by the Audit Committee. The Audit Committee has determined that the rendering of the services other than audit services by Ernst&nbsp;&amp; Young LLP is compatible with
maintaining the independence of the independent registered public accounting firm. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><FONT STYLE="white-space:nowrap">Pre-Approval</FONT> of Services </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">During 2017 and 2016, the Audit Committee of the Board <FONT STYLE="white-space:nowrap">pre-approved</FONT> the audit and <FONT
STYLE="white-space:nowrap">non-audit</FONT> services to be performed by Exelixis&#146; independent registered public accounting firm, Ernst&nbsp;&amp; Young LLP. <FONT STYLE="white-space:nowrap">Non-audit</FONT> services are defined as services
other than those provided in connection with an audit or a review of our financial statements. The Audit Committee <FONT STYLE="white-space:nowrap">pre-approves</FONT> all audit and <FONT STYLE="white-space:nowrap">non-audit</FONT> services rendered
by Ernst&nbsp;&amp; Young LLP. The Audit Committee generally <FONT STYLE="white-space:nowrap">pre-approves</FONT> specified services in the defined categories of audit services, audit-related services, tax services and all other services up to
specified amounts. <FONT STYLE="white-space:nowrap">Pre-approval</FONT> may also be given as part of the Audit Committee&#146;s approval of the scope of the engagement of the independent registered public accounting firm or on an individual explicit
<FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">case-by-case</FONT></FONT> basis before the independent auditor is engaged to provide each service. The Audit Committee or its chairman, whom the Audit Committee has designated as a <FONT
STYLE="white-space:nowrap">one-person</FONT> subcommittee with <FONT STYLE="white-space:nowrap">pre-approval</FONT> authority, <FONT STYLE="white-space:nowrap">pre-approved</FONT> all audit fees, audit-related fees, tax fees and other fees in 2017
and 2016. Any <FONT STYLE="white-space:nowrap">pre-approvals</FONT> by the subcommittee must be and were presented to the Audit Committee at its next scheduled meeting. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">24</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Report of the Audit Committee </FONT></P>
<p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">R<SMALL>EPORT</SMALL> <SMALL>OF</SMALL> <SMALL>THE</SMALL>
A<SMALL>UDIT</SMALL> C<SMALL>OMMITTEE</SMALL> </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>The material in this report is not &#147;soliciting material,&#148; is not deemed
&#147;filed&#148; with the Securities and Exchange Commission and is not deemed to be incorporated by reference in any filing of Exelixis under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made
before or after the date hereof and irrespective of any general incorporation language in any such filing. </I></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In connection with the
audited consolidated financial statements for the fiscal year ended December&nbsp;29, 2017, of Exelixis, Inc. (&#147;Exelixis&#148;), the Audit Committee of the Board of Directors of Exelixis has: </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:7%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">(1) reviewed and discussed the audited financial statements for the fiscal year ended December&nbsp;29, 2017, with management of
Exelixis; </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:7%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">(2) discussed with Ernst&nbsp;&amp; Young LLP, Exelixis&#146; independent registered public accounting firm
(&#147;Ernst&nbsp;&amp; Young&#148;), the matters required to be discussed by Auditing Standard No.&nbsp;1301, <I>Communications with Audit Committees</I>, as adopted by the Public Company Accounting Oversight Board (&#147;PCAOB&#148;); and
</FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:7%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">(3)&nbsp;received the written disclosures and the letter from Ernst&nbsp;&amp; Young required by applicable
requirements of the PCAOB regarding Ernst&nbsp;&amp; Young&#146;s communications with the Audit Committee concerning independence, and has discussed with Ernst&nbsp;&amp; Young that accounting firm&#146;s independence. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Based on the foregoing, the Audit Committee has recommended to the Board of Directors that the audited financial statements be included in
Exelixis&#146; Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Audit Committee: </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>Jack L.
Wyszomierski, Chairman </I></FONT></P> <P STYLE="margin-top:3pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>Charles Cohen </I></FONT></P>
<P STYLE="margin-top:3pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>Stelios Papadopoulos </I></FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">25</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">P<SMALL>ROPOSAL</SMALL> 3 </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#6d6d6d">A<SMALL>DVISORY</SMALL> V<SMALL>OTE</SMALL> <SMALL>ON</SMALL> <SMALL>THE</SMALL> C<SMALL>OMPENSATION</SMALL> <SMALL>OF</SMALL> <SMALL>THE</SMALL>
N<SMALL>AMED</SMALL> E<SMALL>XECUTIVE</SMALL> O<SMALL>FFICERS</SMALL> </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Our stockholders are entitled to vote to approve, on an advisory
basis, the compensation, as disclosed in this Proxy Statement, of our Chief Executive Officer, Chief Financial Officer and the other executive officers appearing in the table entitled &#147;Summary Compensation Table&#148; later in this Proxy
Statement (collectively, the Named Executive Officers). This vote is not intended to address any specific item of compensation, but rather the overall compensation of our Named Executive Officers and the philosophy, policies and practices described
in this Proxy Statement. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The compensation of our Named Executive Officers subject to the vote is disclosed in &#147;Compensation
Discussion and Analysis,&#148; and the compensation tables and the related narrative disclosure contained in this Proxy Statement. As discussed in the &#147;Compensation Discussion and Analysis&#148; section of this Proxy Statement, the success of
biopharmaceutical companies is significantly influenced by their work forces. We believe it is critical to our business that we retain our core team of highly qualified employees, including our executive officers. Large pharmaceutical and
biopharmaceutical companies and strong local competitors have aggressively recruited our executives and other skilled employees, with the most critical positions at our company among those that are the most in demand. In light of these
circumstances, we have designed our executive compensation program to help attract and retain highly qualified individuals with relevant experience in the biopharmaceutical industry to manage the varied aspects of our evolving business. The primary
objective of our executive compensation program is to retain and motivate our core team of highly qualified employees, including our Named Executive Officers, and align their compensation with our critical business objectives and performance, as
well as with the interests of our stockholders. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Board encourages our stockholders to read the disclosures set forth in the
&#147;Compensation Discussion and Analysis&#148; section of this Proxy Statement to review the correlation between compensation and performance, as well as compensation actions taken in 2017. The Board believes that our executive compensation
program effectively aligns executive pay with our performance and results in the attraction and retention of highly talented executives. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Accordingly, the Board recommends that our stockholders vote FOR the following resolution: </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:7%; margin-right:7%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&#147;<B>RESOLVED,</B> that the compensation paid to the our Named Executive Officers, as disclosed pursuant to
Item&nbsp;402 of Regulation <FONT STYLE="white-space:nowrap">S-K,</FONT> including the Compensation Discussion and Analysis, compensation tables and narrative discussion, is hereby APPROVED.&#148; </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Required Vote and Board of Directors Recommendation </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Advisory approval of Proposal 3
requires the affirmative vote of a majority of the shares present or represented by proxy and entitled to vote at the Annual Meeting. Abstentions will be counted toward the tabulation of votes cast on the proposal and will have the same effect as
votes against this proposal. Broker <FONT STYLE="white-space:nowrap">non-votes</FONT> will have no effect. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Our stockholders have
expressed a preference, and our Board has determined, to hold an advisory vote on executive compensation annually. We are presenting this Proposal 3 as required by Section&nbsp;14A of the Securities Exchange Act of 1934, as amended. Our Board
believes that approval of Proposal 3 is in our best interests and the best interests of our stockholders for the reasons stated above. Because the vote is advisory, it is not binding on the Board or on us. Nevertheless, the views expressed by our
stockholders, whether through this vote or otherwise, are important to management and the Board and, accordingly, the Compensation Committee and Board intend to consider the results of this vote in making determinations in the future regarding
executive compensation arrangements. Your vote will serve as an additional tool to guide the Compensation Committee and Board in continuing to improve the alignment of our executive compensation programs with business objectives and performance and
with the interests of our stockholders. </FONT></P> <P STYLE="font-size:24pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><div style="max-width:100%;margin-left:0%; margin-right:0%;background-color:#e5e5e5;;padding-top:2pt;padding-bottom:3pt">
<P STYLE="margin-top:0pt; margin-bottom:0pt; padding-top:0pt; font-size:12pt; font-family:arial" ALIGN="center"><FONT COLOR="#ff4c00"><B>THE BOARD OF DIRECTORS RECOMMENDS A VOTE &#147;FOR&#148; PROPOSAL 3. </B></FONT></P></div>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">26</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Security Ownership of Certain Beneficial Owners and Management </FONT></P>
<p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">SECURITY OWNERSHIP OF CERTAIN BENEFICIAL OWNERS AND MANAGEMENT </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table sets forth certain information regarding the ownership of our common stock as of March&nbsp;2, 2018, (except as noted) by:
(i)&nbsp;each director and nominee for director; (ii)&nbsp;each of the executive officers named in the Summary Compensation Table; (iii)&nbsp;all current executive officers and directors of Exelixis as a group; and (iv)&nbsp;all those known by us to
be beneficial owners of more than five percent of our common stock. </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="69%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD VALIGN="bottom" WIDTH="9%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B>Beneficially<FONT COLOR="#ffffff">&nbsp;Owned(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name of Beneficial
Owner</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number&nbsp;of<BR>Shares&nbsp;of<BR>Common&nbsp;Stock</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Percentage<BR>of&nbsp;Total</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Executive Officers and
Directors</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D. (2)</FONT></P></TD>

<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">3,731,695</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.2</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D. (3)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,954,029</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner (4)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">420,608</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D. (5)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">860,729</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D. (6)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,124,691</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Charles Cohen, Ph.D. (7)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">608,317</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Carl B. Feldbaum, Esq. (8)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">304,020</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Maria C. Freire, Ph.D. (9)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Alan M. Garber, M.D., Ph.D.
(10)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">348,026</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Vincent T. Marchesi, M.D., Ph.D.
(11)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">393,010</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Stelios Papadopoulos, Ph.D.
(12)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,367,198</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">George Poste, D.V.M., Ph.D., FRS
(13)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">288,903</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">George A. Scangos, Ph.D. (14)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,820,753</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Julie A. Smith (15)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">66,874</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Lance Willsey, M.D. (16)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">789,156</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Jack L. Wyszomierski (17)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">368,299</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">All current directors, executive officers as a
group (17 persons) (18)</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">14,807,376</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.8</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>5% Stockholders</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">FMR LLC (19)</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">245 Summer Street</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Boston, Massachusetts 02210</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">36,439,460</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12.3</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">The Vanguard Group (20)</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">100 Vanguard Blvd.</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Malvern, Pennsylvania 19355</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">26,351,871</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">8.9</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Meditor Group Ltd. (21)</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Wessex House, 3rd Floor</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">45 Reid Street</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">Hamilton HM12, Bermuda</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">16,484,638</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.6</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">BlackRock, Inc. (22)</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">55 East 52nd Street</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.56em; text-indent:-1.00em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">New York, New York 10055</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">16,321,767</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">5.5</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Less than one percent. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"> <P ALIGN="left" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:arial; font-size:10pt"><FONT COLOR="#3f3f3f">This table is based upon information supplied by executive officers and directors and upon
information gathered by us about principal stockholders known to us. Unless otherwise indicated in the footnotes to this table and subject to community property laws where applicable, we believe that each of the stockholders named in this table has
sole voting and investment power with respect to the shares indicated as beneficially owned. Applicable percentages are based on </FONT></P></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">27</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">

<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%">&nbsp;</TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">
296,528,278 shares outstanding on March&nbsp;2, 2018, adjusted as required by rules promulgated by the SEC. The percentage of beneficial ownership as to any person as of a particular date is
calculated by dividing the number of shares beneficially owned by such person, which includes the number of shares as to which such person has the right to acquire voting or investment power within 60 days of March&nbsp;2, 2018, by the sum of the
number of shares outstanding as of such date plus the number of shares as to which such person has the right to acquire voting or investment power within 60 days of March&nbsp;2, 2018. Consequently, the denominator for calculating beneficial
ownership percentages may be different for each beneficial owner. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 169,698 shares held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July&nbsp;21, 1994, as amended. Also includes 3,538,217 shares
Dr.&nbsp;Morrissey has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018. Also includes 17,127 shares held by Mr.&nbsp;Morrissey under our 401(k) Plan, determined based upon information provided in plan
statements. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 1,767,053 shares Dr.&nbsp;Schwab has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018. Also includes 14,287 shares held by Dr.&nbsp;Schwab under
our 401(k) Plan, determined based upon information provided in plan statements. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(4)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 333,437 shares Mr.&nbsp;Senner has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018. Also includes 2,174 shares held by Mr.&nbsp;Senner under our
401(k) Plan, determined based upon information provided in plan statements. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(5)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 608,999 shares Mr.&nbsp;Hessekiel has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018. Also includes 475 shares held by Mr.&nbsp;Hessekiel under
our 401(k) Plan, determined based upon information provided in plan statements. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(6)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 1,048,967 shares Dr.&nbsp;Lamb has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018. Also includes 16,515 shares held by Dr.&nbsp;Lamb under our
401(k) Plan, determined based upon information provided in plan statements. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(7)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 360,137 shares Dr.&nbsp;Cohen has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 5,873 of which would be subject to repurchase by us, if so
exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(8)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 269,287 shares Mr.&nbsp;Feldbaum has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 5,873 of which would be subject to repurchase by us, if so
exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(9)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Dr. Freire became a director on April 5, 2018 and concurrently was granted a one-time initial award pursuant to the 2017 Directors&#146; Policy, consisting of (i) an option to purchase 28,240
shares of our common stock and (ii) an RSU award representing 14,120 shares of our common stock, each of which will vest in accordance with the terms of the 2017 Directors&#146; Policy, described under &#147;Compensation of Directors&#151;Equity
Compensation Arrangements&#148; above. However, as the one-time initial award was granted subsequent to March 2, 2018, the effective date of this table, she did not have beneficial ownership of any of these shares as of March 2, 2018.
</FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(10)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 286,697 shares Dr. Garber has the right to acquire pursuant to options exercisable within 60 days of March 2, 2018, 5,873 of which would be subject to repurchase by us, if so exercised.
</FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(11)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 272,940 shares Dr.&nbsp;Marchesi has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 2,922 of which would be subject to repurchase by us, if so
exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(12)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 338,727 shares Dr.&nbsp;Papadopoulos has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 2,922 of which would be subject to repurchase by us, if
so exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(13)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 211,348 shares Dr.&nbsp;Poste has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 2,922 of which would be subject to repurchase by us, if so
exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(14)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 8,963 shares held by Dr.&nbsp;Scangos and Leslie S. Wilson, as Trustees of The Jennifer Wilson Scangos Trust, and 8,963 shares held by Dr.&nbsp;Scangos and Leslie S. Wilson, as Trustees of
The Katherine Wilson Scangos Trust. Also includes 333,510 shares Dr.&nbsp;Scangos has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 5,873 of which would be subject to repurchase by us, if so exercised.
Also includes 5,669 shares held by Dr.&nbsp;Scangos under our 401(k) Plan, determined based upon information provided in plan statements. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(15)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 66,111 shares Ms.&nbsp;Smith has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 35,130 of which would be subject to repurchase by us, if so
exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(16)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 320,883 shares Dr.&nbsp;Willsey has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 5,873 of which would be subject to repurchase by us, if so
exercised. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(17)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Includes 295,339 shares Mr.&nbsp;Wyszomierski has the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 2,922 of which would be subject to repurchase by us, if
so exercised. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">28</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Security Ownership of Certain Beneficial Owners and Management </FONT></P>
<p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(18)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Total number of shares includes 4,407,836 shares of common stock held by our current directors and executive officers as of March&nbsp;2, 2018, and entities affiliated with such directors and
executive officers. Also includes 10,333,192 shares our directors and executive officers have the right to acquire pursuant to options exercisable within 60 days of March&nbsp;2, 2018, 76,183 of which would be subject to repurchase by us, if so
exercised. Also includes 66,348 shares held by our current directors and executive officers under our 401(k) Plan, determined based upon information provided in plan statements. </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(19)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">FMR LLC reported that (a)&nbsp;it has sole voting power with respect to 9,813,751 of these shares, (b)&nbsp;FMR LLC and Abigail P.&nbsp;Johnson each have sole dispositive power of all of these
shares and (c)&nbsp;Fidelity Growth Company Fund has sole voting power with respect to 14,889,267 of these shares. Ms.&nbsp;Johnson is a Director, the Vice Chairman and the Chief Executive Officer of FMR LLC. FMR LLC also reports that FMR Co., Inc.
beneficially owns 5% or greater of our common stock. The foregoing information is based solely on a Schedule 13G/A filed with the SEC on February&nbsp;13, 2018, which provides information only as of December&nbsp;29, 2017, and, consequently, the
beneficial ownership of these reporting persons may have changed between December&nbsp;29, 2017 and March&nbsp;2, 2017. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(20)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The Vanguard Group reported that it has sole voting power over 159,258 of such shares, shared voting power over 39,980 of these shares, sole dispositive power over 26,175,453 of such shares and
shared dispositive power over 176,418 of such shares. The information is based solely on a Schedule 13G/A, filed with the SEC on February&nbsp;9, 2018, which provides information only as of December&nbsp;31, 2017, and, consequently, the beneficial
ownership of Vanguard may have changed between December&nbsp;31, 2017 and March&nbsp;2, 2018. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(21)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">These shares are beneficially owned by Meditor Group Ltd., or Meditor, and Meditor European Master Fund Ltd., or MEMF, an investment management client and subsidiary of Meditor. Meditor reported
that it and MEMF each have shared voting and dispositive power over the shares. The foregoing information is based solely on a Schedule 13G/A filed with the SEC on January&nbsp;4, 2018, which provides information only as of December&nbsp;31, 2017,
and, consequently, the beneficial ownership of Meditor and MEMF may have changed between December&nbsp;31, 2017 and March&nbsp;2, 2018. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(22)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">BlackRock, Inc. reported that it has sole voting power over 15,258,340 of such shares, and that it has sole dispositive power over all of the shares. The information is based solely on a Schedule
13G/A, filed with the SEC on January&nbsp;29, 2018, which provides information only as of December&nbsp;31, 2017, and, consequently, the beneficial ownership of BlackRock may have changed between December&nbsp;31, 2017 and March&nbsp;2, 2018.
</FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">29</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">EXECUTIVE OFFICERS </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following chart sets forth certain information regarding our executive officers as of March&nbsp;29, 2018: </FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="26%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="69%"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ff4c00"><B>Name</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#ff4c00"><B>Age</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#ff4c00"><B>Position</B></FONT></TD></TR>


<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.&nbsp;(1)</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT COLOR="#3f3f3f">57</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">President and Chief Executive Officer</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT COLOR="#3f3f3f">61</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">President, Product Development and Medical Affairs and Chief Medical Officer</FONT></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT COLOR="#3f3f3f">50</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Executive Vice President and Chief Financial Officer</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Patrick J. Haley</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT COLOR="#3f3f3f">42</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Senior Vice President, Commercial</FONT></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center"><FONT COLOR="#3f3f3f">49</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Executive Vice President and General Counsel</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">57</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">Executive Vice President, Scientific Strategy and Chief Scientific Officer</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Please see &#147;Class&nbsp;III Directors Continuing in Office until the 2020 Annual Meeting&#148; in this Proxy Statement for Dr.&nbsp;Morrissey&#146;s biography. </FONT></TD></TR></TABLE>
<P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Gisela M. Schwab, M.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>President, Product Development and Medical Affairs and Chief Medical Officer</B></FONT></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D., has served as President, Product Development and Medical Affairs and Chief Medical Officer since February 2016. Previously
she served as Executive Vice President and Chief Medical Officer from January&nbsp;2008 to February 2016 and as Senior Vice President and Chief Medical Officer from September 2006 to January 2008. From 2002 to 2006, she held the position of Senior
Vice President and Chief Medical Officer at Abgenix, Inc., a human antibody-based drug development company. She also served as Vice President, Clinical Development, at Abgenix from 1999 to 2001. Prior to working at Abgenix, from 1992 to 1999, she
held positions of increasing responsibility at Amgen Inc., most recently as Director of Clinical Research and Hematology/Oncology Therapeutic Area Team Leader. From August 2011 through July 2014, Dr.&nbsp;Schwab served as a member of the board of
directors of Topotarget A/S, a publicly-held biopharmaceutical company. Since June 2012 she has served as a member of the board of directors of Cellerant Therapeutics, Inc. a privately-held biopharmaceutical company and since March 2015, she has
served as a member of the board of directors of Nordic Nanovector A.S., a Norwegian biotechnology company. She received her Doctor of Medicine degree from the University of Heidelberg, trained at the University of Erlangen-Nuremberg and the National
Cancer Institute and is board certified in internal medicine and hematology and oncology.</FONT></P></TD></TR>
</TABLE> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Christopher J. Senner</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Executive Vice President and Chief Financial Officer</B></FONT></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner, has served as Executive Vice President and Chief Financial Officer (and in such capacity, as our principal financial officer
and principal accounting officer, as defined under applicable securities laws) since July 2015. Prior to joining Exelixis, Mr.&nbsp;Senner served as Vice President, Corporate Finance for Gilead Sciences, Inc., a biopharmaceutical company, from March
2010 to July 2015, where he was accountable for controllership, tax, treasury and corporate and operational financial planning. Mr.&nbsp;Senner previously spent eighteen years at Wyeth, a pharmaceutical company acquired by Pfizer Inc. in 2009, in a
variety of financial roles with increasing responsibility, most notably as Chief Financial Officer of Wyeth&#146;s U.S. pharmaceuticals business and the BioPharma Business Unit. Mr.&nbsp;Senner holds a B.S. in Finance from Bentley
College.</FONT></P></TD></TR>
</TABLE> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="100%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>P.J. Haley</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Senior Vice President, Commercial</B></FONT></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">P.J. Haley, has served as the company&#146;s Senior Vice President, Commercial since December 2016 and has held positions of progressive Commercial
leadership since September 2010, serving as Vice President, Commercial from November 2014 to November 2016, Executive Director, Sales&nbsp;&amp; Marketing from September 2013 to October 2014, Senior Director, Marketing from March 2012 to August
2013, and as Director, Marketing from September 2010 to February 2012. Prior to joining Exelixis, from 2007 to 2010, he held positions of increasing responsibility at Genentech, Inc., on the Avastin marketing team, most recently Group Product
Manager. Between 2003 and 2007, Mr.&nbsp;Haley served in various sales and marketing roles at Amgen, Inc. He served as an analyst at PWC Securities, Lehman Brothers and Accenture from 1998 to 2001. Mr.&nbsp;Haley holds a Masters of Business
Administration from University of Michigan, Ross School of Business, and a Bachelor of Arts in Art History and Medieval and Renaissance Studies from Duke University.</FONT></P></TD></TR>
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 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">30</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Executive Officers </FONT></P>
<p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Jeffrey J. Hessekiel, J.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Executive Vice President and General Counsel</B></FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D., has served as Executive Vice President and General Counsel since February 2014 and as its Secretary from October 2014 to
September 2017. From 2012 to 2014, he held the position of Senior Counsel at Arnold&nbsp;&amp; Porter Kaye Scholer LLP, where he advised emerging growth and public companies, primarily in the life sciences sector, on complex legal issues connected
with strategic transactions, healthcare compliance programs and investigations, and regulatory matters. Prior to working with Arnold&nbsp;&amp; Porter, from 2002 to 2012, he held positions of increasing responsibility at Gilead Sciences, Inc., most
recently as Chief Compliance&nbsp;&amp; Quality Officer where he was responsible for the creation and management of Gilead&#146;s Corporate Compliance&nbsp;&amp; Quality department. From 1998 to 2002, Mr.&nbsp;Hessekiel held the position of
Associate, working on both litigation and corporate matters for Wilson Sonsini Goodrich and Rosati PC. Mr.&nbsp;Hessekiel also worked as an Associate focusing on litigation matters for Heller Ehrman LLP from 1996 to 1998. Prior to joining Heller
Ehrman LLP, Mr.&nbsp;Hessekiel also worked for several international <FONT STYLE="white-space:nowrap">non-governmental</FONT> organizations. Mr.&nbsp;Hessekiel received his J.D. from The George Washington University Law School and is admitted to
practice in California. Mr.&nbsp;Hessekiel received a B.A. in Political Science from Duke University.</FONT></P></TD></TR>
</TABLE> <P STYLE="font-size:18pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:0.22em; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00"><I>Peter Lamb, Ph.D.</I></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Executive Vice President, Scientific Strategy and Chief Scientific Officer</B></FONT></P></TD></TR>
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<TD VALIGN="top"> <P STYLE="margin-top:0pt;margin-bottom:0pt;border-bottom:1px solid #999999">&nbsp;</P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D., has served as Executive Vice President, Scientific Strategy and Chief Scientific Officer since February 2016. Previously, he
served as Executive Vice President, Discovery Research and Chief Scientific Officer from September 2009 to February 2016, as Senior Vice President, Discovery Research and Chief Scientific Officer from January 2007 until September 2009, as Vice
President, Discovery Pharmacology from December&nbsp;2003 until January 2007 and as Senior Director, Molecular Pharmacology and Structural Biology from October 2000 until December 2003. Prior to joining Exelixis, from June 1992 until September 2000,
Dr.&nbsp;Lamb held positions of increasing responsibility at Ligand Pharmaceuticals, a pharmaceutical company, most recently serving as Director of Transcription Research. Dr.&nbsp;Lamb has held post-doctoral research fellowships at the Carnegie
Institution, Department of Embryology, with Dr.&nbsp;S.L. McKnight and the University of Oxford with Dr.&nbsp;N.J. Proudfoot, working in the field of gene regulation. He has authored numerous articles in the fields of gene expression, signal
transduction and oncology, and is an author on multiple issued and pending U.S. patents. He has a Ph.D. in Molecular Biology from the ICRF/University of London and a B.A. in Biochemistry from the University of Cambridge.</FONT></P></TD></TR>
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 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">31</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">COMPENSATION OF EXECUTIVE OFFICERS </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Compensation Discussion and Analysis </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">This Compensation Discussion and
Analysis explains the strategy, design, and decision-making related to our compensation programs and practices for our principal executive officer, our principal financial officer and our three other most highly compensated executive officers, who
we refer to collectively as our Named Executive Officers. This Compensation Discussion and Analysis is intended to provide perspective on the information contained in the tables that follow this discussion. For fiscal 2017, our Named Executive
Officers were: </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ff4c00"><B>Named Executive Officers</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#ff4c00"><B>Title</B></FONT></TD></TR>


<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">President and Chief Executive Officer</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">President, Product Development and Medical Affairs and Chief Medical Officer</FONT></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Executive Vice President and Chief Financial Officer</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Executive Vice President and General Counsel</FONT></TD></TR>
<TR BGCOLOR="#e5e5e5" STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Executive Vice President, Scientific Strategy and Chief Scientific Officer</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">While the principal purpose of this Compensation Discussion and Analysis is to discuss the compensation of our
Named Executive Officers, many of the programs discussed apply to other members of senior management who, together with the Named Executive Officers, are collectively referred to as our executive officers. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Executive Summary </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Our
Business </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We are a biotechnology company committed to the discovery, development and commercialization of new medicines to improve
care and outcomes for people with cancer. Since our founding in 1994, three products discovered at&nbsp;Exelixis&nbsp;have progressed through clinical development, received regulatory approval, and entered the marketplace. Two are derived from
cabozantinib, an inhibitor of multiple tyrosine kinases including MET, AXL and VEGF receptors: CABOMETYX<SUP STYLE="font-size:85%; vertical-align:top">&reg;</SUP> (cabozantinib) approved for advanced renal cell carcinoma, or RCC, and COMETRIQ<SUP
STYLE="font-size:85%; vertical-align:top">&reg;</SUP> (cobimetinib) approved for progressive, metastatic medullary thyroid cancer, or MTC. The third product, COTELLIC<SUP STYLE="font-size:85%; vertical-align:top">&reg;</SUP> (cobimetinib), is a
formulation of cobimetinib, an inhibitor of MEK, and is marketed under a collaboration with Genentech, Inc. (a member of the Roche Group), or Genentech; it is approved as part of a combination regimen to treat advanced melanoma. Both cabozantinib
and cobimetinib have shown potential in a variety of forms of cancer and are the subject of broad clinical development programs for multiple potential oncology indications. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>2017 Financial Performance Highlights </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">We delivered strong financial results in fiscal 2017, increasing total revenue by 136% year over year and ending fiscal 2017 with a healthy cash and investments balance of $457.2&nbsp;million, of which $452.0&nbsp;million was
available for operations and that we plan to reinvest in our business in order to drive the anticipated expansion and depth of our product offerings. Other key financial highlights from fiscal 2017 include: </FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Cabozantinib franchise net product revenue of $349.0&nbsp;million, resulting in our second consecutive year of record net product revenue; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Total revenue of $452.5&nbsp;million, reflecting both strong product demand and significant financial contributions generated from our collaborations; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="3%">&nbsp;</TD>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Total operating expenses of $286.6&nbsp;million, up 31% from the prior fiscal year, demonstrating disciplined expense management by operating within the parameters of our issued guidance;
</FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="3%">&nbsp;</TD>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Our first full year of operating profit, resulting in diluted earnings per share of $0.49, up from diluted net loss per share of $(0.28) from the prior fiscal year; and </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Retired all of our outstanding debt, including our&nbsp;$80.0 million&nbsp;term loan with Silicon Valley Bank and $113.9&nbsp;million of Secured Convertible Notes due 2018 held by entities
associated with Deerfield Management Company, L.P., or the Deerfield Notes. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">32</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Stock Price Performance </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Our strong financial and corporate performance in fiscal 2017 also resulted in meaningful value creation for our stockholders. As illustrated
below, in fiscal 2017 our stock price continued to significantly outperform both our 2017 peer group (described below) as a whole, as well as the Russell 3000 Index. </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>FY2015-FY2017 Total Shareholder Return vs 2017 Peer Group </B></FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="center">


<IMG SRC="g489684g56c18.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The foregoing graph compares, for the three-year period ended&nbsp;December&nbsp;31, 2017, the cumulative total
stockholder return for our common stock, the Russell 3000 Index and an average of the companies that form our 2017 peer group. The graph assumes that $100 was invested on December&nbsp;31, 2014 in each of our common stock, the Russell 3000 Index and
in each company in our 2017 peer group, and assumes reinvestment of any dividends. It places our corporate performance in context, highlighting the strength of our results versus our 2017 peers as a whole and the market. When considering corporate
performance factors, the Compensation Committee&#146;s decision-making in 2017 was rooted in the understanding that our Named Executive Officers led our company to achieve this exceptional success on a relative basis. The stock price performance on
the graph is not necessarily indicative of future stock price performance. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>2017 Corporate Performance Highlights </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In fiscal 2017, we continued to drive growth by executing on our strategy. Key highlights of our corporate performance included: </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Successful Commercialization of CABOMETYX for Previously Treated Advanced RCC </B></FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">In the U.S., we expanded our distribution channel in order to improve patient access to CABOMETYX and continued to focus on educating physicians on CABOMETYX&#146;s unique product profile, which
translated into strong product demand in 2017. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">We worked closely with our partner Ipsen Pharma SAS, or Ipsen, in support of its regulatory strategy and commercialization efforts for CABOMETYX outside the U.S. and Japan, which culminated in
regulatory approvals in Australia, Switzerland and South Korea, as well as launches and completed and/or ongoing pricing and reimbursement negotiations in a majority of European Union, or EU, member states. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Expansion of CABOMETYX Label as a Treatment for Previously Untreated Advanced RCC </B></FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">On December&nbsp;19, 2017, approximately two months ahead of the assigned&nbsp;Prescription Drug User Fee Act, or PDUFA, action date, the&nbsp;U.S. Food and Drug Administration, or FDA, approved
CABOMETYX for an expanded indication to include previously untreated patients with advanced RCC, the most common form of advanced kidney cancer in adults. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">33</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Ipsen submitted to&nbsp;the European Medicines Agency, or EMA, the regulatory dossier for CABOMETYX as a treatment for previously untreated, advanced or metastatic RCC in
the&nbsp;EU&nbsp;on&nbsp;August 28, 2017; the filing was subsequently validated on&nbsp;September 8, 2017. </FONT></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f"><B>Positive Results from the CELESTIAL Trial in Previously Treated Advanced HCC following Second Interim Analysis </B></FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">In October 2017, we announced that CELESTIAL, our company-sponsored, global phase 3 trial comparing cabozantinib to placebo in patients with advanced hepatocellular carcinoma, or HCC, who had
previously progressed on or were intolerant to sorafenib and up to one additional therapy, met its primary endpoint, with cabozantinib providing a statistically significant and clinically meaningful improvement in overall survival compared to
placebo. </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Based on the results of CELESTIAL,&nbsp;on March&nbsp;15, 2018, we submitted a supplemental New Drug Application, or sNDA, to the FDA, for CABOMETYX as a treatment for patients with previously
treated advanced HCC. </FONT></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Evaluation of Cabozantinib in Combination with Multiple Immune Checkpoint
Inhibitors </B></FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">We initiated a phase 3 pivotal trial in previously untreated, advanced or metastatic RCC in collaboration with Bristol-Myers Squibb Company, or BMS, which, pursuant to its amended protocol, is
evaluating the combination of cabozantinib with BMS&#146;s immune checkpoint inhibitor, nivolumab. </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">We initiated a phase 1/2 trial in collaboration with BMS in patients with both previously treated and previously untreated advanced HCC, evaluating cabozantinib in combination with nivolumab and in
combination with both nivolumab and ipilimumab. </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">We initiated a phase 1b trial with various expansion cohorts evaluating cabozantinib and atezolizumab, F. <FONT STYLE="white-space:nowrap">Hoffmann-La</FONT> Roche Ltd&#146;s, or Roche&#146;s, <FONT
STYLE="white-space:nowrap">PD-L1</FONT> checkpoint inhibitor, in patients with advanced genitourinary malignancies, which, pursuant to its amended protocol, includes expansion cohorts for <FONT STYLE="white-space:nowrap">non-small</FONT> cell lung
cancer, or NSCLC, and castration-resistant prostate cancer, or CRPC, in addition to the previously included RCC and urothelial carcinoma. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Expansion of Global Partnership for Cabozantinib to Japan </B></FONT></P>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">On January&nbsp;30, 2017, we entered into a collaboration and license agreement with Takeda Pharmaceutical Company Limited, or Takeda, for the commercialization and further clinical development of
cabozantinib in Japan. </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">In December 2017, Takeda confirmed that the first patient was enrolled in its bridging study evaluating cabozantinib in second-line advanced RCC in Japan. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; margin-left:4%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Continued Development of COTELLIC </B></FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Genentech advanced the development program for cobimetinib, with three phase 3 pivotal trials exploring the combination of cobimetinib with atezolizumab or atezolizumab alone in colorectal
carcinoma (IMblaze370) and BRAF wild-type melanoma&nbsp;(IMspire170), and the combination of cobimetinib with atezolizumab and vemurafenib in BRAF V600 mutant melanoma (IMspire150). </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="7%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Enrollment for IMblaze370 was completed in the first quarter of 2017, and Genentech has announced that <FONT STYLE="white-space:nowrap">top-line</FONT> results for the trial are expected during the
first half of 2018. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">34</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>2017 Compensation Program Highlights </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">In 2017, we achieved significant corporate and financial milestones that helped position us to be able to deliver upon our goal of driving the expansion and depth of our product offerings. The Compensation Committee believes that
the 2017 compensation of our employees, including our Named Executive Officers, reflects not only those achievements, but will also encourage appropriate efforts towards the achievement of our commercial objectives and both short-term and long-term
research and development goals. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In light of the above, the Board and Compensation Committee took the following key actions with respect
to 2017 compensation for our Named Executive Officers: </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="bottom"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; text-indent:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Key
Compensation Actions</FONT></B></FONT></P> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Description</FONT></B></FONT></P>
<P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:1pt" align="left">&nbsp;</P></TD></TR>


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<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" BGCOLOR="#e5e5e5"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Modest Salary Increases for Named Executive
Officers</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">In February 2017, the Compensation Committee increased base salaries of our Named Executive Officers by between 3.5% and 6% over salaries for 2016.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" BGCOLOR="#e5e5e5"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Granted Substantial Portion of Long-Term
Incentive Compensation in the Form of Stock Options</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">In October 2017, as part of our ongoing equity incentive compensation program, the Compensation Committee granted stock options and restricted stock units, or RSUs, to
focus our Named Executive Officers on the company&#146;s long-term performance. For Dr. Morrissey, the mix was 75% stock options and 25% RSUs, and for the other Named Executive Officers, the mix was 50% stock options and 50% RSUs. Stock options are
a key aspect of aligning our Named Executive Officers&#146; compensation with the interests of our stockholders because they provide a return to our Named Executive Officers only if the market price of our common stock appreciates over the stock
option term.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" BGCOLOR="#e5e5e5"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Approved Annual Cash Bonuses Aligned
with Strong Company Performance</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">In February 2018, the Compensation Committee approved the payment of cash bonuses in the amount of 100% of each Named Executive Officer&#146;s 2017 target cash bonuses
resulting from the Compensation Committee&#146;s assessment of the overall achievement of our corporate goals during 2017, and the contribution of each Named Executive Officer toward such achievements.</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Compensation Practices and Governance Highlights </B></FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="bottom" WIDTH="2%"></TD>
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<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Pay for Performance</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Link the compensation of our Named Executive Officers to the success of our corporate goals</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Stockholder Alignment</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Align the interests of our Named Executive Officers with those of our stockholders through the use of long-term equity incentives</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Equity Plan Features</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Apply a maximum <FONT STYLE="white-space:nowrap">7-year</FONT> term for
stock options</FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">No repricing of underwater stock options without prior stockholder approval</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">2017 Plan includes minimum vesting requirements of no less than one year for all types of awards, subject to limited
exceptions</FONT></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Stock Ownership
Guidelines</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Apply stock ownership guidelines to directors and executive officers to further align their interests with those of our stockholders</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Change in Control
Provisions</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">No excessive change in control or severance payments</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Provide &#147;double-trigger&#148; change in control benefits</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">No tax <FONT STYLE="white-space:nowrap">gross-ups</FONT> on severance or change in control benefits</FONT></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Perquisites, Retirement and<BR>Pension
Benefits</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Named Executive Officers do not receive excessive perquisites or post-termination retirement or pension benefits that are not available to all employees
generally</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Prohibition on Hedging and<BR>Margin
Loans</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5" STYLE=" BORDER-BOTTOM:1px solid #ffffff">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #ffffff" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Prohibit hedging and purchases on margin by executive officers and directors.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="middle" BGCOLOR="#6d6d6d"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:0.40em; font-size:10pt; font-family:arial"><FONT COLOR="#FFFFFF"><B>Meaningful Limits on Pledging</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#e5e5e5">&nbsp;&nbsp;</TD>
<TD VALIGN="top" BGCOLOR="#e5e5e5"><FONT COLOR="#3f3f3f">Limit pledging of our common stock by executive officers and directors to circumstances where the individual can clearly demonstrate the financial capacity to repay the loan without resort to
the pledged securities. No executive officers or directors pledged our common stock during 2017.</FONT></TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">35</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Objectives of the Compensation Program </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The primary goals of our executive compensation program are to: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Provide market-competitive compensation that attracts, retains and motivates our executive officers to achieve our short- and long-term business objectives; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="3%">&nbsp;</TD>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Align our executive officers&#146; compensation with the interests of our stockholders; and </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Reward our executive officers for our success in achieving our corporate goals. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">The success of any biopharmaceutical company is significantly influenced by the quality of its work force. We believe it is critical to our business that we retain our core team of highly qualified employees, including our Named
Executive Officers. As a testament to their high value in the marketplace, large pharmaceutical and biopharmaceutical companies and strong local competitors have aggressively recruited our executives and other skilled employees, with the most
critical positions at our company among those that are the most in demand. In light of these circumstances, each year we design our executive compensation program to help attract and retain highly qualified individuals with relevant experience in
the biopharmaceutical industry to manage the varied aspects of our growing business operations. In fact, our Named Executive Officers have an average tenure of over ten years with Exelixis, which we believe is evidence of the effectiveness of our
compensation program with respect to retention. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">How We Determine Executive Compensation </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Role of the Compensation Committee, Compensation Consultants and Executive Officers in Compensation Decisions </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee is responsible for determining and approving the compensation packages offered to our Named Executive Officers. When
appropriate, the Compensation Committee will solicit the input of, or present its recommendations on compensation matters for consideration and approval to, the full Board. The Compensation Committee acts on behalf of the Board in discharging the
Board&#146;s responsibilities with respect to overseeing our compensation policies, plans, and programs, and establishing and reviewing general policies relating to compensation and benefits of our employees. The Compensation Committee also
administers our equity and other incentive plans. The Compensation Committee does not delegate any of its functions to others in determining executive compensation. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Under its charter, the Compensation Committee has the authority to obtain the advice and assistance from external advisors to assist it in the
performance of its duties. In accordance with this authority, the Compensation Committee engages external advisors to advise on executive officer compensation, including base salaries, bonus targets and equity compensation, as well as director
compensation. These advisors also prepare industry compensation data, assist with the development of our peer group, and advise the Compensation Committee on best industry practices and relevant changes to regulations that may impact the
Compensation Committee&#146;s decision-making process with regard to executive officer and director compensation determinations. In November 2016, the Compensation Committee retained the consulting firm Compensia, to compile biopharmaceutical
industry compensation data for the purpose of developing a peer group for fiscal 2017 and to help us evaluate the compensation of our executive officers and directors against that peer group. Compensia also prepared a market analysis of long-term
incentive compensation of our executive officers compared to our peer group. This market analysis was reviewed with the Compensation Committee and used to guide the Compensation Committee&#146;s decisions regarding annual long-term equity
compensation determinations in October 2017. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Dr.&nbsp;Morrissey, our President and Chief Executive Officer, also participates in the
Compensation Committee&#146;s deliberations with respect to Named Executive Officer compensation other than his own, and is not present during deliberation and voting on his compensation. Each year, Dr.&nbsp;Morrissey and other senior management
develop annual corporate business goals for the company, which are reviewed and, subject to their input, approved by the Compensation Committee and the Board. In determining Named Executive Officer compensation recommendations for 2017, our Chief
Executive Officer solicited the input of and received documentary support from our senior human resources personnel. The Compensation Committee also received documentary support, including peer group and industry data, from third-party sources with
respect to base salaries, target annual cash bonuses, and equity compensation. In particular, in January 2017, at the direction of the Compensation Committee, our senior human resources personnel retained Radford to provide a market analysis of
executive compensation of our executive officers compared to our peer group that was previously approved by the Compensation Committee based on advice from Compensia. This market analysis was reviewed with the Compensation Committee and used to
guide the Compensation Committee&#146;s decisions regarding 2017 base salaries and 2017 bonus targets in February 2017. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">36</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee did not engage any other consultants in 2017 with respect to executive and/or director compensation matters, other than
Compensia and Radford. The Compensation Committee assessed the independence of both Compensia and Radford pursuant to SEC rules and concluded that the work performed by both compensation consultants for the Compensation Committee had not raised any
conflict of interest. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Compensation Committee Process </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In setting the level of salary, cash bonus and equity compensation for our Named Executive Officers, the Compensation Committee typically considers
various factors, including: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the performance of the company during the prior year; </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the performance of each Named Executive Officer during the prior year; </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the criticality of each Named Executive Officer&#146;s skill set and expected future contributions to our business; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the growing complexity of our business resulting in increased workloads and responsibilities of our Named Executive Officers; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the appropriate mix of compensation for each Named Executive Officer; </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the percentage of vested versus unvested equity awards held by each Named Executive Officer; and </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">market data for our industry and specific peer group. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The
Compensation Committee balances each of these factors against our cash resources and the critical need to prioritize clinical development investments over other expenditures, as well as our aggregate equity burn rate. When establishing each element
of a Named Executive Officer&#146;s compensation, the Compensation Committee also typically takes into consideration the executive officer&#146;s historical salary, cash bonus and equity compensation, as well as his or her total current and
potential compensation. Using this process, our Compensation Committee strives to ensure that our executive compensation program as a whole is competitive. In determining the amount and mix of compensation elements and whether each element provides
the correct incentives and rewards for performance consistent with our short and long-term goals and objectives, the Compensation Committee relies on its subjective judgment about each individual rather than adopting a formulaic approach to
compensatory decisions. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee believes that it is important when making its compensation decisions to be informed
as to the current practices of comparable publicly-held companies. To this end, the Compensation Committee reviews market data, which include competitive information relating to compensation levels for comparable positions in the biotechnology and
life sciences sector. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Stockholder Advisory Vote on Executive Compensation </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We provide our stockholders with the opportunity to cast an annual advisory vote on our executive compensation program, which the Compensation
Committee takes into account when determining the compensation of the company&#146;s Named Executive Officers. At our annual meeting of stockholders held in May 2017, approximately 97% of the votes present and entitled to vote on the <FONT
STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">say-on-pay</FONT></FONT> proposal voted in favor of the proposal. Our Compensation Committee considered the outcome of the vote on the <FONT STYLE="white-space:nowrap"><FONT
STYLE="white-space:nowrap">say-on-pay</FONT></FONT> proposal to be an endorsement of the Compensation Committee&#146;s policies and practices and has continued to conduct its review of executive compensation generally consistent with past practice.
</FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Competitive Assessment&#151;Peer Group and Market Data </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee reviews and makes adjustments to the composition of the peer group as often as deemed necessary, to account for changes
in both our business and the businesses of the companies in the peer group. As discussed above, the Compensation Committee, in consultation with Compensia, developed a peer group to be used as a reference point for setting base salaries, bonus
targets and annual equity incentive compensation for 2017. The Compensation Committee does not have a specific target compensation level for the Named Executive Officers and does not otherwise use a formulaic approach to setting pay at a particular
positioning within the market data. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In developing the 2017 peer group, the Compensation Committee considered the significant evolution
of our business and meaningful developments in comparison to the 2016 peer group companies. It also considered what other companies might make suitable additions to the 2017 list. The key qualitative and quantitative considerations that influenced
the development </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">37</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
of the 2017 peer group were: (1)&nbsp;industry&#151;including, biotechnology and pharmaceutical companies; (2)&nbsp;therapeutic area, including companies with an oncology product focus, while
avoiding the inclusion of companies marketing solely orphan and rare disease drugs; (3)&nbsp;stage of business, as reflected by the existence of a marketed product; (4)&nbsp;location of headquarters and whether the company is traded on a major U.S.
exchange; (5)&nbsp;market capitalization between 0.25x&#151;4.0x of our then-current market capitalization (approximately $750 million&#151;approximately $12.0 billion) and (6)&nbsp;revenue between 0.5x&#151;5.0x of our then revenue (approximately
$60 million&#151;approximately $600 million). Due to the limited number of companies that had comparable revenue growth expectations after taking into consideration the possibility that our revenue could grow appreciably due to increased CABOMETYX
sales during 2017, the Compensation Committee expanded the top end of the revenue range from 2.0x of current revenue to 5.0x. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Following
this analysis, the Compensation Committee identified the following 19 publicly-traded, U.S&#151;based biotechnology/pharmaceutical companies as our peer group to be used in reviewing compensation for 2017: </FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="31%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="29%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" COLSPAN="5" ALIGN="center" STYLE="BORDER-LEFT:1px solid #ff4c00; BORDER-TOP:2.00pt solid #ff4c00; BORDER-RIGHT:1px solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-left:8pt; padding-right:2pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.40em; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#ffffff"><B>Fiscal 2017 Peer Group</B></FONT></P></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">ACADIA Pharmaceuticals Inc.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Intercept Pharmaceuticals, Inc.</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Neurocrine Biosciences, Inc.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Acorda Therapeutics, Inc.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Ionis Pharmaceuticals, Inc.</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Seattle Genetics, Inc.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Alkermes Public Limited
Company</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Ironwood Pharmaceuticals, Inc.</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Supernus Pharmaceuticals, Inc.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">ARIAD Pharmaceuticals, Inc.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Lexicon Pharmaceuticals, Inc.</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">TESARO, Inc.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Corcept Therapeutics
Incorporated</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Momenta Pharmaceuticals, Inc.</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">The Medicines Company</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Eagle Pharmaceuticals, Inc.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Nektar Therapeutics</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Vanda Pharmaceuticals, Inc.</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Halozyme Therapeutics, Inc.</FONT></P></TD>

<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
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<IMG SRC="g489684g02e02.jpg" ALT="LOGO">
 </P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Of these companies, 13 companies (ARIAD Pharmaceuticals, Inc., Corcept Therapeutics Incorporated, Eagle
Pharmaceuticals, Inc., Halozyme Therapeutics, Inc., Intercept Pharmaceuticals, Inc., Ironwood Pharmaceuticals, Inc., Ionis Pharmaceuticals, Inc., Momenta Pharmaceuticals, Inc., Nektar Therapeutics, Neurocrine Biosciences, Inc., Seattle Genetics,
Inc., Supernus Pharmaceuticals, Inc. and Vanda Pharmaceuticals Inc.) were in our 2016 peer group. The Compensation Committee did not include in our 2017 peer group six companies (Alnylam Pharmaceuticals, Inc., Array BioPharma, Inc., FibroGen, Inc.,
Ophthotech Corporation, Portola Pharmaceuticals, Inc. and PTC Therapeutics, Inc.) that were in our 2016 peer group, because they were either a clinical-stage company or had a market capitalization that fell far below the selection criteria.
</FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In addition to the analysis of the compensation data from the peer group, due to our anticipated growth during 2017, the Compensation
Committee also reviewed the compensation levels and disclosed program design for executive officers of Endo International plc, United Therapeutics Corporation, Jazz Pharmaceuticals Public Limited Company, Medivation, Inc., BioMarin Pharmaceutical
Inc., Incyte Corporation, Vertex Pharmaceuticals Incorporated and Alexion Pharmaceuticals, Inc. to provide perspective on what executive officer pay would look like at the next stage of growth. We refer to this group of companies as our reference
peer group. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">38</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Elements of Compensation </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Our
executive compensation program consists of three principal components: base salary, annual discretionary cash bonus, and equity incentive compensation. Our Named Executive Officers are also eligible to participate, on the same basis as other
employees, in our 401(k) Plan, our employee stock purchase plan and other benefit programs generally available to all employees. The Compensation Committee has not established any formal policies or guidelines for allocating compensation between
current and long-term incentive compensation, or between cash and <FONT STYLE="white-space:nowrap">non-cash</FONT> compensation. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Base Salary</I></B><B>.</B> We pay a base salary to each of our Named Executive Officers to provide an appropriate and competitive base level
of current cash income. The Compensation Committee reviews annually each Named Executive Officer&#146;s base salary and sets salary generally based on the criticality of such officer&#146;s skill set and expected future contributions to our
business, the performance of the Named Executive Officer during the prior year, the growing complexity of our business and market data for our industry and specific peer group, with each of these factors balanced against the critical need to
effectively manage our cash resources to prioritize clinical development investments over other expenditures, as well as other elements of the executive officer&#146;s compensation. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Annual Cash Bonus</I></B><B>.</B> We pay annual cash bonuses to our Named Executive Officers to align the Named Executive Officers&#146;
compensation with our business objectives, and to enable us to retain and reward executive officers who fulfill or exceed performance expectations. Our Compensation Committee determines bonus targets (expressed as a percentage of base salary) based
on the seniority of the applicable position. The bonus targets are reviewed annually by the Compensation Committee, taking into consideration market data for our industry and specific peer group. Actual cash bonuses have been discretionary but
subject to the Compensation Committee&#146;s assessment as to the achievement of our corporate goals on an overall basis and the Compensation Committee&#146;s subjective determination of each Named Executive Officer&#146;s contribution toward the
achievement of such goals. Whether or not a bonus is paid is solely within the discretion of our Compensation Committee, which will weigh the relative importance of achievement or failure to achieve certain of our corporate goals against the
achievement or failure to achieve others, all in the context of our overall annual performance. The actual bonus awarded in any year, if any, may be more or less than the target, depending on individual performance and the achievement of our
corporate goals, as well as other factors, including the critical need to effectively manage our cash resources to prioritize clinical development investments over other expenditures. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Equity Incentive Compensation</I></B><B>.</B> We have granted, and intend to continue to grant, stock options and RSUs, and potentially other
types of equity incentive awards, to align our Named Executive Officers&#146; compensation with achievement of the company&#146;s key business objectives and its long-term performance, thereby linking their compensation to the interests of our
stockholders. The Compensation Committee believes that stock options are an effective equity-based tool to motivate our Named Executive Officers to pursue critical company interests aggressively, because options only have value if the value of our
company as reflected by our stock price increases over time. The Compensation Committee believes that RSUs are another effective instrument for employee retention, and that they also have incentive value since the value of RSUs increases as our
stock price increases over time. RSUs are also generally less dilutive to our stockholders than stock options. Further, RSUs continue to have incentive value even in the event of a severe stock price decline, unlike stock options that can lose their
incentive value in such an event. Because of the overall importance to our success of aggressively pursuing our strategic goals, as well as the critical need to effectively manage our cash resources to prioritize clinical development investments
over other expenditures, a significant portion of the Named Executive Officers&#146; total compensation typically has consisted of, and is expected to continue to consist of, equity-based awards in the form of stock options and RSUs. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Change in Control and Severance Benefit Plan</I></B><B>.</B> We have adopted a Change in Control and Severance Benefit Plan, in which all of
our Named Executive Officers participate, to maintain the competitiveness of our executive compensation program and to remove or at least reduce an executive&#146;s potential personal bias against a takeover attempt. It also provides incentives to
our executive officers to remain with our company, and objectively evaluate and facilitate an acquisition of our company should consideration of such a transaction be determined appropriate by the Board and in the best interests of our stockholders.
A description of this plan is set forth below under the heading &#147;Potential Payments Upon Termination or Change in Control.&#148; This plan is a double-trigger plan, in which each participant receives benefits under the plan only if the
participant is terminated without cause or is constructively terminated in connection with a change in control, rather than a single-trigger plan, in which each participant would receive benefits under the plan if a change in control occurs or the
participant resigns for any reason after a change in control. We adopted a double-trigger plan because it protects the participants from post-change in control events that are not related to the participants&#146; performance, encourages them to
stay throughout a transition period in the event of a change in control, and does not provide for benefits for a participant who remains with the surviving company in a comparable position. The Compensation Committee believes that these benefits are
an important element of the Named Executive Officers&#146; retention and motivation and are consistent with </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">39</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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compensation arrangements provided in a competitive market for executive talent, and that the benefits of such severance rights agreements, including generally requiring a release of claims
against us as a condition to receiving any severance benefits are in our best interests. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Other Benefits</I></B><B>.</B> We have a
401(k) Plan in which substantially all of our employees, including our Named Executive Officers, are entitled to participate. Employees contribute their own funds, as salary deductions, on a <FONT STYLE="white-space:nowrap">pre-tax</FONT> basis.
Contributions may be made up to plan limits, subject to government limitations. We match employee contributions <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">dollar-for-dollar</FONT></FONT> up to $8,500 in each calendar year, in
the form of Exelixis common stock. Our employee stock purchase plan allows for eligible employees to purchase shares of our common stock at a price equal to the lower of 85% of the closing price on the first day of the
<FONT STYLE="white-space:nowrap">six-month</FONT> offering period or 85% of the closing price on the final day of such offering period, subject to specified limits. We provide health care, dental and vision benefits to all full-time employees,
including our Named Executive Officers. These and other standard health and welfare benefits are available to all eligible employees, subject to applicable laws. We provide these benefits because we believe they are consistent and competitive with
the market practices of our peers. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">2017 Compensation Decisions </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Through our compensation program, we seek to align pay and performance. To that end, a significant portion of our Named Executive Officers&#146;
compensation is &#147;at risk&#148; because it is variable, performance-based and in large part dependent on the success of our company. <FONT STYLE="white-space:nowrap">At-risk</FONT> compensation includes long-term equity based awards, the value
of which depends on increases in the price of our common stock, and annual incentive cash bonuses, which relate to the overall level of achievement of our company performance goals and, other than for Dr.&nbsp;Morrissey, each Named Executive
Officer&#146;s individual contributions toward the achievement of such performance goals. The following charts highlight the pay mix for our Chief Executive Officer and all of our other Named Executive Officers as a group. </FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" ALIGN="center"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><B>Chief Executive Officer</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><B>Pay Mix<SUP STYLE="font-size:85%; vertical-align:top">1</SUP></B></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="center"><B>91% of CEO 2017 Compensation is Considered At-Risk</B></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><B>All Other Named Executive Officers (as a group)</B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><B>Pay Mix<SUP STYLE="font-size:85%; vertical-align:top">1</SUP></B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="center"><B>85% of All Other Named Executive Officers (as a group) 2017 Compensation is Considered At-Risk</B></P>
<P STYLE="font-size:12pt; margin-top:0pt; margin-bottom:1pt" align="left">&nbsp;</P></TD></TR>
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<TD WIDTH="1%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f"><B><SUP STYLE="font-size:85%; vertical-align:top">1</SUP></B></FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f"><B><SUP STYLE="font-size:85%; vertical-align:top"></SUP></B>Percentages calculated from values reported in the 2017 Summary Compensation Table </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>2017 Base Salaries </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In
considering the appropriate level of base salaries for our Named Executive Officers, the Compensation Committee did not apply a formula, but rather employed a holistic analysis emphasizing: (1)&nbsp;the individual contribution of the Named Executive
Officer to our exceptional 2016 commercial, regulatory and financial achievements; (2)&nbsp;the criticality of each Named Executive Officer&#146;s skill set and relative expected future contributions to our business; (3)&nbsp;the growing complexity
of our business resulting in increased workloads and responsibilities of each of our Named Executive Officers; and (4)&nbsp;other competing business priorities for our company that require substantial investment. The Compensation Committee also
considered the base salaries of similarly situated executives at our peer group companies, and in contemplation of the potential continuation of our rapid growth, of similarly situated executives at our reference peer group companies, for an
understanding of whether our compensation program is competitively positioned to retain our highly qualified Named Executive Officers. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">40</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Following such analysis, in February 2017, the Compensation Committee determined that each Named Executive Officer should receive a modest increase
in his or her base salary for 2017 as follows: </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-left:8pt"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT
 COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">2016 Base<BR>Salary</FONT></B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">2017 Base<BR>Salary</FONT></B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Percentage<BR>Increase</FONT></B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-RIGHT:1px solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-right:2pt">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">850,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">901,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.00</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">600,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">636,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.00</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">540,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">567,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.00</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">489,038</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">511,045</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.50</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">460,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">476,100</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">3.50</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>2017 Annual Cash Bonuses </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In February 2017, the Compensation Committee determined 2017 target annual cash bonuses (expressed as a percentage of base salary) should remain at
the same levels as 2016 for all Named Executive Officers other than Dr.&nbsp;Morrissey (i.e., 50% for Dr.&nbsp;Schwab and 45% for each of Mr.&nbsp;Senner, Mr.&nbsp;Hessekiel and Dr.&nbsp;Lamb). The Compensation Committee&#146;s decision regarding
2017 target bonuses was based on its subjective assessment that the percentages of base salaries previously established were appropriate and continued to align us competitively with our 2017 peer group. Following a review of a market analysis
prepared by Radford, in order to better align Dr.&nbsp;Morrissey&#146;s total cash compensation with those of chief executive officers of the companies included in our 2017 peer group and in recognition of his greater role in determining the course
of, and ability to influence the future of the company, as well as the importance of his leadership to the company&#146;s achievement of its 2017 business and financial objectives, the Compensation Committee approved an increase to
Dr.&nbsp;Morrissey&#146;s 2017 target annual bonus to 75% (expressed as a percentage of base salary). The target bonus amounts for the company&#146;s cash bonuses are intended to serve as general guidelines for the determination of actual bonuses
and are not designed to set formulaic payout levels. The Compensation Committee determined at the time that it would not be appropriate to apply an objective formulaic approach during a period of such rapid change and evolution for the company.
</FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In connection with establishing the bonus program for 2017, the Compensation Committee reviewed management&#146;s proposed commercial,
product development, pipeline development, finance and legal goals and recommended them to the Board for approval. In February 2017, the Board then reviewed and approved the proposed company goals for 2017, as identified in the table below. In
selecting these goals, the Compensation Committee and the Board believed that they were appropriate drivers for our business, as they provided a balance between the efforts necessary to continue to execute on a successful commercial launch for
CABOMETYX and generate further growth in our business, all while maintaining a solid financial position, which together, would enhance stockholder value. At the time the 2017 corporate performance goals were set, the Compensation Committee and
management believed that such goals were challenging and achieving them would require not only continued strong commercial performance, favorable clinical trial results, business development opportunities, and prudent fiscal and legal management,
but also a high level of effort and execution on the part of our Named Executive Officers. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">During 2017, management reported regularly
to the Compensation Committee and the Board on the status of the company&#146;s performance against these goals, including in formal meetings in February, May, September and December. In February 2018, the Compensation Committee and the Board
evaluated the company&#146;s performance in relation to the 2017 goals, as well as, other than for Dr.&nbsp;Morrissey, each Named Executive Officer&#146;s individual contribution to the achievement of those goals. As further described below, the
Compensation Committee concluded that 2017 was a year of meaningful </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">41</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
accomplishments during which the Company <FONT STYLE="white-space:nowrap">partially-met,</FONT> met or exceeded each of the goals, as highlighted by the corporate achievements identified in the
table below. </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="22%"></TD>
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<TD WIDTH="26%"></TD>
<TD VALIGN="bottom"></TD>
<TD WIDTH="38%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="10%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B>CORPORATE GOALS</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B>ACHIEVEMENTS</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-RIGHT:1px solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-right:2pt"><FONT COLOR="#ffffff"><B>EVALUATION</B></FONT></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="middle" ROWSPAN="5" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" BGCOLOR="#ededed"><FONT STYLE="font-size:14pt" COLOR="#ff4c00"><B>Product Development</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>File a sNDA for CABOMETYX as a treatment for patients with previously untreated advanced RCC based on CABOSUN results</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT
 COLOR="#3f3f3f">&#8194;&#8202;Based on the results from CABOSUN, filed a sNDA with the FDA for CABOMETYX as a treatment for patients with previously untreated advanced RCC. The FDA granted Priority Review of the filing and assigned a PDUFA action
date of February&nbsp;15, 2018.</FONT></P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT
 COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Received FDA approval for CABOMETYX as a treatment for patients with previously untreated advanced RCC on December&nbsp;19, 2017, two months ahead
of the assigned PDUFA date.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Exceeded</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Conduct a second interim analysis, or IA, for CELESTIAL, and if positive, file a sNDA for CABOMETYX as a treatment for patients with previously treated advanced
HCC</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT
 COLOR="#3f3f3f">&#8194;&#8202;Completed a second IA for CELESTIAL, which met its primary endpoint, with cabozantinib providing a statistically significant and clinically meaningful improvement in overall survival compared to placebo.</FONT></P>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Following internal
preparations and discussions with the FDA during 2017, filed a sNDA on March&nbsp;15, 2018 for CABOMETYX as a treatment for patients with previously treated advanced HCC.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Partially Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Initiate late stage development of cabozantinib in combination with an immunotherapy in patients with previously untreated advanced RCC and in bladder
cancer</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT
 COLOR="#3f3f3f">&#8194;&#8202;Initiated CheckMate 9ER, a phase 3 pivotal trial evaluating the combination of cabozantinib with nivolumab in previously untreated, advanced or metastatic RCC and CheckMate 040 evaluating the same combination and also
cabozantinib with both nivolumab and ipilimumab in a phase 1/2 trial in both previously treated and previously untreated advanced HCC.</FONT></P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Initiated a phase 1b
trial evaluating cabozantinib and atezolizumab in patients with advanced genitorurinary malignancies, which, pursuant to its amended protocol includes expansion cohorts for NSCLC and CRPC, in addition to the previously included RCC and
UC.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Partially Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Continue the broad evaluation of cabozantinib in other tumor types through externally-sponsored studies</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Managed 31 ongoing
and 29 planned externally sponsored trials evaluating the clinical and therapeutic potential of cabozantinib, including those administered through our Cooperative Research and Development Agreement with National Cancer Institute&#146;s Cancer
Therapy Evaluation Program and our investigator sponsored trial program.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>Support cabozantinib worldwide regulatory filings by cabozantinib partners</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f">
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Supported EMA
validation of the regulatory dossier submitted by Ipsen, for CABOMETYX as a treatment for patients with previously untreated advanced RCC in the EU.</FONT></P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Supported Ipsen&#146;s
receipt of regulatory approvals in Australia, Switzerland and South Korea for CABOMETYX as a treatment for advanced RCC in adults following prior VEGF targeted therapy, launches in France, Germany, Italy, Spain and the United Kingdom and associated
pricing and reimbursement negotiations in the EU member states.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">Exceeded</FONT></TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">42</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
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<TR>
<TD WIDTH="19%"></TD>
<TD VALIGN="bottom"></TD>
<TD WIDTH="25%"></TD>
<TD VALIGN="bottom"></TD>
<TD WIDTH="42%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="10%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B>CORPORATE GOALS</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="center" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00"><FONT COLOR="#ffffff"><B>ACHIEVEMENTS</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-TOP:2.00pt solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:2.00pt solid #ff4c00; BORDER-RIGHT:1px solid #ff4c00; BORDER-BOTTOM:2.00pt solid #ff4c00; padding-right:2pt"><FONT COLOR="#ffffff"><B>EVALUATION</B></FONT></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="middle" ROWSPAN="2" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" BGCOLOR="#e5e5e5"><FONT STYLE="font-size:14pt" COLOR="#ff4c00"><B>Commercial</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Continue to execute successful commercial launch for CABOMETYX in the U.S. and exceed the net product revenue target established by the Board</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Generated&nbsp;
cabozantinib franchise net product revenue of $349.0&nbsp;million during 2017.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Exceeded</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>Develop and implement launch strategy to ensure organizational readiness should the company receive FDA approval for CABOMETYX as a treatment for patients with
previously untreated advanced RCC and/or patients with previously treated advanced HCC</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f">
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;The organization was
launch-ready immediately upon the FDA&#146;s approval for CABOMETYX as a treatment for patients with previously untreated advanced RCC on December&nbsp;19, 2017.</FONT></P> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Continued launch
preparedness efforts in line with regulatory timelines for a potential approval of CABOMETYX as a treatment for patients with previously treated advanced HCC.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="middle" ROWSPAN="2" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" BGCOLOR="#e5e5e5"><FONT STYLE="font-size:14pt" COLOR="#ff4c00"><B>Pipeline Development</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Support licensing efforts for a late preclinical/clinical oncology asset and rapidly advance development of the asset once
<FONT STYLE="white-space:nowrap">in-house</FONT></B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Conducted a worldwide
landscape review of oncology opportunities, followed by due diligence efforts, site visits and early stage partnering discussions for multiple <FONT STYLE="white-space:nowrap">pre-clinical</FONT> and clinical stage oncology assets, resulting in the
execution of an exclusive license and collaboration agreement with StemSynergy Therapeutics, Inc., or StemSynergy, on January&nbsp;8 2018.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><FONT STYLE="white-space:nowrap">Partially-met</FONT></FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>Complete the initial build out of an internal discovery team and advance initial potential programs to a preclinical
<FONT STYLE="white-space:nowrap">go/no-go</FONT> decision (i.e., proof of concept to initiate full discovery program)</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Hired the necessary
full-time employees to enable restart of internal discovery work, conducted multiple <FONT STYLE="white-space:nowrap"><FONT STYLE="white-space:nowrap">proof-of-concept</FONT></FONT> experiments and advanced one program to preclinical
development.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="middle" ROWSPAN="4" ALIGN="center" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" BGCOLOR="#e5e5e5"><FONT STYLE="font-size:14pt" COLOR="#ff4c00"><B>Finance and Legal</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Manage cash balance to a target established by the Board, and manage operating expenses within the budget approved by the Board</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Managed operating
expenses to $286.6&nbsp;million and ended fiscal 2017 with a cash balance of $457.2&nbsp;million.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Execute an agreement with a partner for the development and commercialization of cabozantinib in Japan</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Entered into an
exclusive licensing agreement with Takeda to commercialize current and potential future cabozantinib indications in Japan.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f"><B>Effectively manage the JAMS arbitration hearing&nbsp;in the dispute with Genentech/Roche regarding cobimetinib</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Amended our
collaboration agreement with Genentech in connection with the resolution of our arbitration, which provides for a favorably- revised revenue and cost-sharing arrangement, that became effective as of July&nbsp;1, 2017, and that is applicable to
current and all potential future commercial uses of COTELLIC.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:9pt">
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>Repay outstanding debt with Silicon Valley Bank and the Deerfield Notes</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.33em; text-indent:-1.33em; font-size:9pt; font-family:arial"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT><FONT COLOR="#3f3f3f">&#8194;&#8202;Retired all
outstanding debt, including our $80.0 million&nbsp;term loan with Silicon Valley Bank and our Deerfield Notes in the amount of $123.8&nbsp;million.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">Met</FONT></TD></TR>
</TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">43</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee did not assign any weighting to specific company goals in making its
assessment of overall performance, but rather made its assessment of our overall performance against the goals from a holistic perspective. The Compensation Committee also recognized the individual contributions, other than for Dr.&nbsp;Morrissey,
toward achievement of the corporate goals and the combined contribution of our Named Executive Officers and cohesive management effort that led to these 2017 corporate achievements. Specifically, the Compensation Committee considered the following
contributions from each Named Executive Officer, other than Dr.&nbsp;Morrissey: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Dr. Schwab&#146;s overall leadership of our product development and medical affairs organizations and her performance with respect to the execution of our product development goals in 2017,
particularly with respect to the FDA&#146;s approval of CABOMETYX as a treatment for patients with previously untreated advanced RCC, positive <FONT STYLE="white-space:nowrap">top-line</FONT> results from CELESTIAL, support of cabozantinib worldwide
regulatory filings by collaboration partners, and the initiation of multiple clinical trials of cabozantinib in combination with immunotherapy agents; </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Mr.&nbsp;Senner&#146;s overall leadership of our finance organization and his performance with respect to the execution of our financial goals in 2017, particularly with respect to the repayment of
all of our outstanding debt; </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Mr.&nbsp;Hessekiel&#146;s overall leadership of our legal and compliance organizations and his performance with respect to our business and legal goals in 2017, particularly with respect to the
resolution of our arbitration with Genentech; and </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Dr.&nbsp;Lamb&#146;s overall leadership of our research and discovery organization and his performance with respect to our pipeline development goals, particularly with respect to the progress on
the license and collaboration agreement with StemSynergy and the rebuilding of our discovery organization. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Although the
Compensation Committee determined that, overall, our corporate and financial performance in 2017 exceeded expectations and that this exceptional performance could reasonably have justified above-target bonus payments for Named Executive Officers,
the Compensation Committee was conscious of the importance of financial discipline at this particular juncture in our company&#146;s history and the critical need to effectively manage our cash resources to prioritize clinical development
investments over other expenditures. Therefore, in February 2018, the Compensation Committee approved annual cash bonus payments at 100% of each Named Executive Officer&#146;s target amount, as reflected in the table below. </FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="61%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="5%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="5%"></TD>
<TD VALIGN="bottom" WIDTH="9%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">2017&nbsp;Target<BR>Cash Bonus</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">(% of 2017<BR>Base&nbsp;Salary)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">2017&nbsp;Bonus&nbsp;Payout</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">(% of 2017 Target<BR>Cash Bonus)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">2017&nbsp;Bonus<BR>Payout</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">75</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">675,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">50</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">318,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">45</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">255,150</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">45</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">229,970</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">45</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">100</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">%&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">$</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">214,245</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>2017 Equity Incentive Awards </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In October 2017, the Compensation Committee reviewed the annual equity compensation awards for our Named Executive Officers for 2017. In
determining the form of equity incentive grants for the Named Executive Officers, the Compensation Committee: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">evaluated the status of equity incentive awards held by the Named Executive Officers to assess the retention and incentive values of those awards; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">determined the appropriate size and value of new equity incentive awards for our Named Executive Officers, taking into consideration the need to be competitive in the market to retain the talent
required to continue to execute on the successful commercial launch of CABOMETYX and further advance the cabozantinib development program; and </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">determined the grant of a mix of 75% stock options and 25% RSUs for Dr.&nbsp;Morrissey, and 50% stock options and 50% RSUs for all other Named Executive Officers, to align our Named Executive
Officer&#146;s interests with the interests of our stockholders, while allowing us to minimize dilution and deliver an appropriate level of compensation. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">When determining the appropriate size and value of equity incentive awards, the Compensation Committee asked Compensia to provide guidance with
respect to implementing a program that would incentivize our Named Executive </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">44</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Officers to drive toward the achievement of key company priorities and increase stockholder value over the long-term, while maintaining competitive
market practices and being mindful of the company&#146;s equity burn rate. Compensia prepared a market analysis of long-term incentive compensation of our executive officers compared to our 2017 peer group. However, due to the significant
appreciation of our stock price over the course of 2017, at the time the 2017 equity awards were granted, our market capitalization was positioned at the 85<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> percentile of our 2017 peer group.
While we have historically focused on grant date dollar value when determining the size of ongoing equity awards, the Compensation Committee determined that as a result of this increase in market capitalization, it would be more prudent to evaluate
equity grants for the Named Executive Officers as a percentage of market capitalization of a select <FONT STYLE="white-space:nowrap">sub-set</FONT> of our 2017 peer group, including Seattle Genetics, Inc., Alkermes Public Limited Company and TESARO,
Inc. and one member of our reference peer group Jazz Pharmaceuticals Public Limited Company because the Compensation Committee believed that each of these companies were a good comparator based on its current financial and business characteristics
and trajectory. Reviewing equity grant values as a percent of market capitalization can provide an understanding of how much of a company&#146;s market capitalization is used for executive equity awards and can help to normalize for varying market
capitalizations. At the direction of the Compensation Committee, Compensia prepared an analysis taking the last annual grant reported in each of those companies proxy statements divided by the market capitalization of each company at the time of
grant to determine the percent of market capitalization granted to each Named Executive Officer of those peer companies. The Compensation Committee reviewed the materials provided by Compensia and determined that the equity awards for each of our
Named Executive Officers should be sized substantially below the 50<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> percentile of the equity grants as a percent of market capitalization of this select peer group. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">As part of the decision making process, the Compensation Committee considered the challenges of managing a rapidly evolving organization from one
rooted in drug discovery and development to one focused on product commercialization, as well as Exelixis&#146; need to retain a cohesive management team to facilitate the continued commercial success of CABOMETYX, and the achievement of development
and regulatory objectives that would position the company for future success. The Compensation Committee also believed it was important that the value of the equity awards continue to reflect the individual performance of each Named Executive
Officer during the 2017 fiscal year to date and criticality of each Named Executive Officer&#146;s skill set and expected future contributions to our business, and in October 2017, approved the following grants to the Named Executive Officers:
</FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TR>
<TD WIDTH="72%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="5%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number&nbsp;of&nbsp;Shares<BR>Subject to Time-<BR>Based Stock<BR>Options</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number&nbsp;of&nbsp;Shares<BR>Subject to RSUs</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">480,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">80,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">150,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">75,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">125,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">62,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">50,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">110,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">55,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The stock options for each of the Named Executive Officers have an exercise price of $24.41 per share, the fair
market value of our common stock on the date of grant (October 3, 2017), and expire seven years from the date of grant or earlier upon termination of service with us. All of the stock options vest over a four year period following the grant date and
the RSUs vest annually over approximately a four year period following the first quarterly vesting date (i.e., February 15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP>, May 15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP>,
August&nbsp;15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> and November 15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP>) following the date of grant. Vesting of these stock options and RSUs will cease upon termination of service
as an employee for any reason. The Named Executive Officers are party to our Change in Control and Severance Benefit Plan, which provides for acceleration of vesting of the award in the event of certain specified change in control events involving
us, for the reasons discussed above. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Other Compensation Information </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Timing of Equity Awards </B></FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Annual grants of equity awards to our executive officers, including our Named Executive Officers, are generally determined and approved at <FONT
STYLE="white-space:nowrap">pre-scheduled</FONT> Compensation Committee meetings, with such meeting date typically serving as the grant date. However, the Compensation Committee may sometimes approve the grant of equity awards to executive officers
and other employees in advance of its next scheduled meeting, either at a special meeting or by unanimous written consent, in </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">45</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
connection with certain new hires, promotions and other circumstances where the Compensation Committee deems it appropriate to make such grants. The grant dates for these equity awards are
typically the same date that a newly hired officer begins employment or the effective date of an officer&#146;s promotion, as applicable. Grants made to new hires below the level of Vice President, are approved on a monthly basis by our Equity Award
Committee, comprised solely of Dr.&nbsp;Morrissey, acting in his capacity as a director pursuant to authority delegated to him by the Compensation Committee. All stock options are granted with an exercise price that is not less than the closing
price of our common stock on The Nasdaq Global Select Market on the grant date. We have no plan or practice to&nbsp;time&nbsp;option grants in coordination with the release of <FONT STYLE="white-space:nowrap">non-public</FONT> information,&nbsp;and
we do not time&nbsp;the release of <FONT STYLE="white-space:nowrap">non-public</FONT> information&nbsp;to affect the value of executive compensation. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f"><B>Stock Ownership Guidelines </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In February 2018, the Board adopted Stock Ownership Guidelines for our Named
Executive Officers in order to further align their financial interests with those of our stockholders, as well as to promote sound corporate governance. The Stock Ownership Guidelines for our Named Executive Officers provide for ownership targets as
follows: </FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="29%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD WIDTH="69%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B>Position</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Ownership Level</FONT></B></FONT></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Chief Executive Officer</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Lesser of 160,000 shares or a value equivalent to 5 times annual base salary</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Other Named Executive
Officers</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">Lesser of 25,000 shares or a value equivalent to 1.5 times annual base salary</FONT></TD></TR>
</TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In considering appropriate guidelines for our executive officers and directors, the Compensation Committee reviewed
a market analysis of stock ownership guidelines of our peer group established by the Compensation Committee for 2018 executive and director compensation determinations. The approved guidelines are representative of the median of our 2018 peer group
and provide for a &#147;lesser of&#148; approach to address stock price volatility often experienced by biotechnology companies. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">All
Named Executive Officers are expected to achieve their stock ownership targets within five years of becoming subject to these guidelines. The policy includes procedures for granting exemptions in the case of severe financial hardship. In determining
ownership levels for each Named Executive Officer under our Stock Ownership Guidelines, credit is provided for shares held outright (including shares owned through trusts, our 401(k) Plan, or by a spouse), as well as 50% of the number of vested, but
unexercised, stock options. No credit is provided for restricted stock units until they vest. The values for all shares determined to be held by Named Executive Officers are based on the <FONT STYLE="white-space:nowrap">200-day</FONT> average stock
price as of the measurement date. As of February&nbsp;15, 2018, the date the stock ownership guidelines were adopted by the Board, all of our Named Executive Officers had met the required ownership targets. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>&#147;Clawback&#148; Policy </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">The Compensation Committee has not yet established a policy to recover bonuses from our executive officers if the performance objectives that led to a bonus determination were to be restated, or found not to have been met to the
extent originally believed by the Compensation Committee. As a public company, if we are required to restate our financial results due to our material noncompliance with any financial reporting requirements under the federal securities laws as a
result of misconduct, our Chief Executive Officer and Chief Financial Officer may be legally required to reimburse us for any bonus or other incentive-based or equity-based compensation they receive, in accordance with the provisions of
Section&nbsp;304 of the Sarbanes-Oxley Act of 2002. Further, the Dodd-Frank Wall Street Reform and Consumer Protection Act, or Dodd-Frank Act, requires that the SEC promulgate rules which would require that, in the event we are required to restate
our financial statements, we &#147;claw back&#148; any bonuses paid based on financial performance that would not have been paid if based on the restated financial performance. The SEC has not yet finalized its &#147;claw back&#148; rules. We expect
that the Compensation Committee and Board will <FONT STYLE="white-space:nowrap">re-evaluate</FONT> the potential adoption of a &#147;claw back&#148; policy after any such rules are promulgated. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Accounting and Tax Considerations </B></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Under FASB ASC 718, we are required to estimate and record an expense for each award of equity compensation (including stock options and RSUs) over the vesting period of the award. As long as stock options and RSUs remain the sole
components of our long-term compensation program, we expect to record stock-based compensation expense on an ongoing basis according to ASC 718. Compensation expense relating to awards subject to performance conditions is recognized if it is
probable that the performance goals will be achieved. The probability of achievement of such goals is assessed on a quarterly basis. The Compensation Committee has considered, and may in the future consider, the grant of restricted stock to our
executive officers in lieu of stock option grants and/or RSU awards. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">46</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Discussion and Analysis </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Section&nbsp;162(m) of the Code, as amended by the Tax Cuts and Jobs Act, limits the deductibility for federal income tax purposes to not more than
$1&nbsp;million of compensation paid to &#147;covered employees&#148; in a calendar year. Prior to the recent enactment of the Tax Cuts and Jobs Act, compensation that qualified as &#147;performance-based compensation&#148; under Section&nbsp;162(m)
of the Code was not subject to this deduction limitation. Pursuant to the Tax Cuts and Jobs Act, this exception for &#147;performance-based compensation&#148; under Section&nbsp;162(m) of the Code was repealed, with respect to taxable years
beginning after December&nbsp;31, 2017, and subject to a transition rule for written binding contracts which were in effect on November&nbsp;2, 2017, and which were not modified in any material respect on or after such date. As a result,
compensation paid to any of our &#147;covered employees&#148; in excess of $1&nbsp;million per taxable year generally will not be deductible unless among other requirements, it is intended to qualify, and is eligible to qualify, as
&#147;performance-based compensation&#148; under Section&nbsp;162(m) of the Code pursuant to the transition relief provided by the Tax Cuts and Jobs Act. Certain equity awards issued prior to the transition date were designed to permit us to qualify
for the performance-based exception, but because of certain ambiguities and uncertainties as to the application and interpretation of Section&nbsp;162(m) of the Code and the regulations issued thereunder, including the uncertain scope of the
transition relief provided by the Tax Cuts and Jobs Act, no assurance can be given that any compensation paid by the Company will be eligible for such transition relief and, therefore, eligible for the &#147;performance-based compensation&#148;
exception under Section&nbsp;162(m) of the Code. To maintain flexibility in compensating our executive officers in a manner designed to promote our objectives, the Compensation Committee has not adopted a policy that requires all compensation to be
deductible. The Compensation Committee is continuing to assess the impact of Section&nbsp;162(m) of the Code, as amended, on its compensation programs, and intends to provide future compensation in a manner consistent with our best interests and
those of our stockholders. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Compensation Policies and Practices as They Relate to Risk Management </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In 2017, the Compensation Committee reviewed our compensation policies and practices and concluded that the mix and design of these policies and
practices are not reasonably likely to encourage our employees to take excessive risks.&nbsp;In connection with its evaluation, the Compensation Committee considered, among other things, the structure, philosophy and design characteristics of our
primary incentive compensation plans and programs in light of our risk management and governance procedures, as well as other factors that may calibrate or balance potential risk-taking incentives.&nbsp;Based on this assessment, the Compensation
Committee concluded that risks arising from our compensation policies and practices for all employees, including executive officers, are not reasonably likely to have a material adverse effect on us. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:arial"><FONT COLOR="#ff4c00">Forward-Looking Statements </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">This
Compensation Discussion and Analysis contains forward-looking statements, including, without limitation, statements related to: our plans to drive the expansion and depth of our product offerings; Genentech&#146;s expectation that <FONT
STYLE="white-space:nowrap">top-line</FONT> results for the IMblaze370 trial are expected during the first half of 2018; potential approval of CABOMETYX as a treatment for patients with previously treated advanced HCC; and other statements that are
not historical fact. Words such as &#147;focused,&#148; &#147;plan,&#148; &#147;intends,&#148; &#147;expected,&#148; &#147;could, &#147;will&#148; or other similar expressions identify forward-looking statements, but the absence of these words does
not necessarily mean that a statement is not forward-looking. In addition, any statements that refer to expectations, projections or other characterizations of future events or circumstances are forward-looking statements. These forward-looking
statements are based upon our current plans, assumptions, beliefs, expectations, estimates and projections. Forward-looking statements involve risks and uncertainties. Actual results and the timing of events could differ materially from those
anticipated in the forward-looking statements as a result of these risks and uncertainties, which include, without limitation: the degree of market acceptance of CABOMETYX, COMETRIQ and COTELLIC and the availability of coverage and reimbursement for
these products; risks and uncertainties related to regulatory review and approval processes and our and our collaborators&#146; compliance with applicable legal and regulatory requirements; risks related to the potential failure of cabozantinib and
cobimetinib, both alone and in combination with other therapies, to demonstrate safety and efficacy in clinical testing; the availability of data at the referenced times;&nbsp;our dependence on our relationship with our collaboration partners,
including the level of their investment in the resources necessary to successfully commercialize cabozantinib and cobimetinib in the territories where they are approved; our ability and the ability of our collaborators to conduct clinical trials of
cabozantinib and cobimetinib, both alone and in combination with other therapies, sufficient to achieve a positive completion; the level of costs associated with our commercialization, research and development,
<FONT STYLE="white-space:nowrap">in-licensing</FONT> or acquisition of product candidates, and other activities; our dependence on third-party vendors; our ability to protect our intellectual property rights; market competition, including the
potential for competitors to obtain approval for generic versions of our marketed products; changes in economic and business conditions, and other factors discussed under the caption &#147;Risk Factors&#148; in our annual report on Form <FONT
STYLE="white-space:nowrap">10-K</FONT> filed with the Securities and Exchange Commission on February&nbsp;26, 2018, and in our future filings with the SEC. The forward-looking statements made in this
</FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">47</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
Compensation Discussion and Analysis speak only as of the date of this proxy statement. We expressly disclaim any duty, obligation or undertaking to release publicly any updates or revisions to
any forward-looking statements contained herein to reflect any change in our expectations with regard thereto or any change in events, conditions or circumstances on which any such statements are based. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">48</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Summary of Compensation </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Summary of Compensation </FONT></P> <P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table shows for the fiscal years ended December&nbsp;29, 2017, December&nbsp;30, 2016 and January&nbsp;1, 2016 (referred to as
fiscal years 2017, 2016 and 2015, respectively), compensation awarded to, paid to or earned by our Chief Executive Officer, our Chief Financial Officer, and our other three most highly compensated executive officers in 2017, which we refer to as our
&#147;Named Executive Officers.&#148; </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Summary Compensation Table </B></FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="41%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name&nbsp;and&nbsp;Principal Position</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Year<BR>(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Salary<BR>($)(2)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Bonus<BR>($)(3)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Stock<BR>Awards<BR>($)(4)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option<BR>Awards<BR>($)(5)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">All Other<BR>Compensation<BR>($)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Total</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B>($)</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">891,781</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">675,750</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,952,800</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">5,911,152</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,100</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">9,439,583</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>President and Chief</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2016</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">841,154</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">800,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">918,600</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">3,700,434</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">7,950</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">6,268,138</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Executive
Officer</I></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">824,423</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">480,001</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2,693,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9,326</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4,007,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">629,493</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">318,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,830,750</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,847,235</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,100</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">4,633,578</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>President, Product Development</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2016</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">591,186</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">375,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">294,800</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,257,579</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,511</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2,527,076</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>and Medical Affairs and Chief</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2015</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">565,800</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">275,092</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,358,996</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">7,950</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2,207,838</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Medical
Officer</I></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner*</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">562,120</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">255,150</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,525,625</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,539,363</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,100</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">3,890,358</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Executive Vice President and</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2016</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">532,923</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">303,750</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">294,800</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,062,084</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">7,950</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2,201,507</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Chief Financial
Officer</I></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">226,923</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(7)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">225,002</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">366,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,809,593</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2,627,518</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">507,067</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">229,970</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,220,500</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,231,490</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">7,076</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">3,196,103</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Executive Vice President and</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2016</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">484,918</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">275,084</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">239,525</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">862,943</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,862,470</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>General
Counsel</I></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">480,332</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">209,588</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,062,021</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,751,941</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">473,190</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">214,245</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,342,550</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,354,639</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,100</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">3,392,724</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Executive Vice President,</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2016</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">453,546</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">258,750</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">239,525</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">967,207</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">7,950</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,926,978</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Scientific Strategy and Chief</I></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">2015</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">437,199</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">190,588</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,028,921</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">9,464</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,666,172</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<I>Scientific
Officer</I></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">*</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Mr.&nbsp;Senner joined Exelixis in July 2015. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The compensation reflected in the Summary Compensation Table reflects a <FONT STYLE="white-space:nowrap">52-week</FONT> period for each of fiscal 2017. 2016 and 2015. </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The amount in this column represents the amount actually paid to each Named Executive Officer for fiscal 2017. For information regarding 2017 base salaries, please see &#147;Compensation Discussion
and Analysis&#151;2017 Compensation Decisions&#151;2017 Base Salaries.&#148; </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The amount in this column represents discretionary cash bonuses awarded for services rendered during the indicated fiscal years by the Named Executive Officers (equity was issued in lieu of cash
for bonuses for 2015). For a description of the company&#146;s discretionary cash bonus program for 2017, see &#147;Compensation Arrangements&#151;Annual Cash Bonuses&#148; following the Grants of Plan Based Awards table. </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(4)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Amounts shown in this column reflect the aggregate grant date fair value in the indicated fiscal year for the RSU awards as computed in accordance with FASB ASC 718. The assumptions used to
calculate the value of RSU awards are set forth in Note 8 of the Notes to Consolidated Financial Statements included in our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, filed
with the SEC on February&nbsp;26, 2018. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(5)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Amounts shown in this column do not reflect compensation actually received or amounts that may be realized in the future by the Named Executive Officers. The amounts shown reflect the aggregate
grant date fair value in the indicated fiscal years for option awards as computed in accordance with FASB ASC 718. The assumptions used to calculate the value of option awards are set forth in Note 8 of the Notes to Consolidated Financial Statements
included in our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, filed with the SEC on February&nbsp;26, 2018. The grant date fair values presented in the table for the
performance-based option awards assume achievement of the highest level of performance conditions, and excludes estimates of forfeiture. There can be no assurance that the stock option awards will ever be exercised (in which case no value will
actually be realized by the executive) or that the value on exercise will be equal to the FASB ASC 718 value shown in this column. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">49</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(6)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Represents the aggregate grant date fair value for the RSU award issued to the Named Executive Officer in lieu of a cash bonus for 2015 as computed in accordance with FASB ASC 718. The assumptions
used to calculate the value of the RSU award is set forth in Note 8 of the Notes to Consolidated Financial Statements included in our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29,
2017, filed with the SEC on February&nbsp;26, 2018. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(7)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Mr.&nbsp;Senner&#146;s base salary for 2015 was $500,000 per year. The amount shown represents the amount of salary he was actually paid in fiscal 2015, taking into account his start date in July
2015. </FONT></TD></TR></TABLE> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Grants of Plan-Based Awards </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table shows for the
fiscal year ended December&nbsp;29, 2017, certain information regarding grants of plan-based awards to the Named Executive Officers: </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT
 COLOR="#3f3f3f"><B>Grants of Plan-Based Awards in Fiscal&nbsp;2017 </B></FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="46%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Grant Date</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">All&nbsp;other&nbsp;stock<BR>awards:<BR>Number of<BR>Shares
of<BR>Stock or Units</FONT></B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">(#)(1)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">All&nbsp;other&nbsp;option<BR>awards:<BR>Number
of<BR>Securities<BR>Underlying<BR>Options</FONT></B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">(#)(2)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right">
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Exercise&nbsp;or<BR>Base&nbsp;Price<BR>of&nbsp;Option</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Awards</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($/Sh)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Grant&nbsp;Date<BR>Fair&nbsp;Value&nbsp;of<BR>Stock
and</FONT></B></FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Awards</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)(3)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">480,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">5,911,152</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">80,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,952,800</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">150,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,847,235</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">75,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,830,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">125,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,539,363</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">62,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,525,625</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">100,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,231,490</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">50,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,220,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">110,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,354,639</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">55,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">1,342,550</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The RSU award was granted pursuant to our 2017 Plan. The RSU award will vest as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the shares subject to the RSU award on
November&nbsp;15, 2018 and thereafter as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the RSU award on each succeeding November&nbsp;15th&nbsp;thereafter until fully vested. Vested shares
will be delivered to the Named Executive Officer on the vesting date, provided that delivery may be delayed pursuant to the terms of the award agreement. Vesting is subject to acceleration as described under the caption &#147;&#151;Potential
Payments Upon Termination or Change in Control&#148; below. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">The option award was granted pursuant to our 2017 Plan and expires seven years from the date of grant or earlier upon termination of service. The option will vest as to 1/4<SUP
STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the <FONT STYLE="white-space:nowrap">one-year</FONT> anniversary of the grant date and will continue to vest thereafter as to 1/48<SUP
STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date. Vesting is subject to acceleration as described under the caption &#147;&#151;Potential Payments
Upon Termination or Change in Control&#148; below. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Amounts shown in this column do not reflect compensation actually received or amounts that may be realized in the future by the Named Executive Officers. The amounts shown in this column reflect
the aggregate grant date fair value in fiscal year 2017 for the option award or the RSU award as computed in accordance with FASB ASC 718. The assumptions used to calculate the value of the option awards and the RSU awards are set forth in Note 8 of
the Notes to Consolidated Financial Statements included in our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, filed with the SEC on February&nbsp;26, 2018. There can be no
assurance that the stock option award will ever be exercised (in which case no value will actually be realized by the executive) or that the value on exercise will be equal to the FASB ASC 718 value shown in this column. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">50</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Arrangements </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Compensation Arrangements </FONT></P> <P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Base Salaries.</I></B> For a description of actions taken by the Compensation Committee with respect to base salaries for our Named
Executive Officers for fiscal 2017, please see &#147;Compensation Discussion and Analysis&#151;2017 Compensation Decisions&#151;2017 Base Salaries&#148; above. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Annual Cash Bonuses.</I></B> Each year the Compensation Committee considers the payment of annual cash bonuses to the Named Executive
Officers for services rendered in the past year. Historically, the payment of bonuses has been entirely within the discretion of the Compensation Committee. While the Compensation Committee established general guidelines related to bonus target
amounts, and the payment of actual cash bonuses was generally aligned with the achievement of our corporate goals and the Compensation Committee&#146;s subjective determination of each Named Executive Officer&#146;s contribution toward the
achievement of such goals, the Compensation Committee exercised broad discretion in determining the amount of cash bonuses and did not attempt to quantify the level of achievement of corporate goals or the extent to which each Named Executive
Officer contributed to Exelixis&#146; overall success. Accordingly, we do not consider the bonuses reported in the Summary Compensation Table to be <FONT STYLE="white-space:nowrap">&#147;Non-Equity</FONT> Incentive Plan Compensation&#148; within the
meaning of applicable SEC rules. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">For additional information with respect to annual bonuses for our Named Executive Officers for fiscal
2017, please see &#147;Compensation Discussion and Analysis&#151;2017 Compensation Decisions&#151;2017 Annual Cash Bonuses&#148; above. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Stock Awards and Option Awards.</I></B> Our 2017 Plan provides for the grant of RSUs and compensatory stock options to our Named Executive
Officers and other employees. In October 2017, we granted time-based stock options and time-based RSU awards to all of our Named Executive Officers to further our longer-term business strategy. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">For information regarding stock option grants to the Named Executive Officers in fiscal 2017, including the number of options granted, the exercise
price and vesting conditions related thereto, please see &#147;Compensation Discussion and Analysis&#151;2017 Compensation Decisions&#151;2017 Equity Incentive Awards&#148; above. As a general matter, the vested portion of options granted to our
Named Executive Officers will expire three months after each Named Executive Officer&#146;s termination of continuous service, subject to extension in certain termination situations or events that can accelerate the vesting, as described under
&#147;Potential Payments Upon Termination or Change in Control&#148; below. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Employment Agreements. </I></B>We have no employment
agreements with our Named Executive Officers. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Change in Control and Severance Benefit Plan.</I></B> Each of our Named Executive
Officers participates in our Change in Control and Severance Benefit Plan, a description of which is included below under the heading &#147;Potential Payments Upon Termination or Change in Control.&#148; </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B><I>Other Compensatory Arrangements.</I></B> Please see &#147;Compensation Discussion and Analysis&#151;Elements of Compensation&#151;Other
Benefits&#148; above for a description of other executive compensatory arrangements, including our 401(k) Plan and other benefits. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">51</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Outstanding Equity Awards at Fiscal Year&#150;End </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table shows certain
information regarding outstanding equity awards at December&nbsp;29, 2017, for the Named Executive Officers. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Outstanding Equity Awards at December&nbsp;29, 2017 </B></FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" ALIGN="center">


<TR>
<TD WIDTH="35%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD COLSPAN="2" VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="14" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option Awards</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Stock Awards</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Grant</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number of<BR>Securities<BR>Underlying<BR>Unexercised<BR>Options<BR>(#)(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number of<BR>Securities<BR>Underlying<BR>Unexercised<BR>Options<BR>(#)(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option<BR>Exercise<BR>Price</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option<BR>Expiration</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number&nbsp;of<BR>Shares<BR>or&nbsp;Units<BR>of&nbsp;Stock<BR>That Have<BR>Not<BR>Vested</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Market<BR>Value&nbsp;of<BR>Shares<BR>or&nbsp;Units<BR>of&nbsp;Stock<BR>That<BR>Have&nbsp;Not<BR>Vested</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Date</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Exercisable</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Unexercisable</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Date</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">(#)(2)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)(3)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.50em; text-indent:-1.00em; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/16/2008</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">50,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.04</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/15/2018</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/26/2009</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">25,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.42</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/25/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/9/2009</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">300,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">7.18</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/8/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/28/2011</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">450,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.50</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/27/2018</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2012</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">402,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.555</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/20/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2013</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">960,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.51</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/17/2020</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/19/2014</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">804,551</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.70</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2021</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/16/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">281,250</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">218,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(4)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.21</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/15/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/11/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">68,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">81,250</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(5)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.20</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/10/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/26/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">112,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">247,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(10)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">15.31</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/25/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/26/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">45,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(7)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1,368,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">480,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(11)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/2/2024</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">80,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">(12)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">2,432,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.50em; text-indent:-1.00em; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/16/2008</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">37,499</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.04</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/15/2018</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/26/2009</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">7,293</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.42</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/25/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/9/2009</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">177,700</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">7.18</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12/8/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/28/2011</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">112,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.50</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/27/2018</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2012</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">123,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.555</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/20/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2013</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">320,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.51</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/17/2020</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/19/2014</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">500,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.70</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2021</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/5/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">250,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.90</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/4/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/16/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">137,812</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">107,188</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(4)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.21</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/15/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/11/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">34,375</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">40,625</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(5)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.20</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/10/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">37,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">82,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">14.74</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">15,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(7)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">456,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">150,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(11)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/2/2024</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">75,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">(12)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">2,280,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.50em; text-indent:-1.00em; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">7/15/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">111,458</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">138,542</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(8)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">3.66</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">7/14/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/16/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">126,562</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">98,438</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(4)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.21</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/15/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">37,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">82,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">14.74</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">15,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(7)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">456,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">125,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(11)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/2/2024</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">62,500</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">(12)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">1,900,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">52</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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<p Style='page-break-before:always'>
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<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Outstanding Equity Awards at Fiscal Year&#150;End </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" ALIGN="center">


<TR>
<TD WIDTH="30%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
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<TD></TD>
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<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
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<TD></TD>
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<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD COLSPAN="2" VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="14" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option Awards</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Stock Awards</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Grant</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number of<BR>Securities<BR>Underlying<BR>Unexercised<BR>Options<BR>(#)(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number of<BR>Securities<BR>Underlying<BR>Unexercised<BR>Options<BR>(#)(1)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option<BR>Exercise<BR>Price</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option<BR>Expiration</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number&nbsp;of<BR>Shares<BR>or&nbsp;Units<BR>of&nbsp;Stock<BR>That Have<BR>Not<BR>Vested</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Market<BR>Value&nbsp;of<BR>Shares<BR>or&nbsp;Units<BR>of&nbsp;Stock<BR>That<BR>Have&nbsp;Not<BR>Vested</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Date</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Exercisable</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Unexercisable</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Date</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">(#)(2)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)(3)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.50em; text-indent:-1.00em; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/10/2014</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">120,416</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9,584</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(9)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">7.27</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/9/2021</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/19/2014</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">145,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.70</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2021</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/5/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">172,698</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.90</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/4/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/16/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">106,875</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">83,125</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(4)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.21</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/15/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">30,468</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">67,032</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">14.74</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12,187</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(7)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">370,485</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(11)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/2/2024</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">50,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">(12)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f">1,520,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.50em; text-indent:-1.00em; font-size:8pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2012</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">123,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.555</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/20/2019</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2013</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">168,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5.51</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/17/2020</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/19/2014</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">400,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.70</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/18/2021</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/5/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">175,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">1.90</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/4/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/16/2015</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">106,875</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">83,125</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(4)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">6.21</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/15/2022</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/11/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">18,333</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">21,667</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(5)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4.20</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2/10/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">30,468</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">67,032</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(6)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">14.74</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/21/2023</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">9/22/2016</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">12,187</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(7)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">370,485</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">110,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">(11)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">24.41</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">10/2/2014</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">10/3/2017</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">55,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">(12)&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">1,672,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option awards granted prior to January&nbsp;26, 2010 were issued under our 2000 Equity Incentive Plan, or 2000 Plan and have vested in full and expire ten years from the date of grant or earlier
upon termination of continuous service. There were no option awards granted to Named Executive Officers on or after January&nbsp;26, 2010 and prior to May&nbsp;18, 2011. Option awards granted on or after May&nbsp;18, 2011, and prior to May&nbsp;28,
2014, were issued under our 2011 Equity Incentive Plan, or 2011 Plan, and are either subject to time-based vesting or were subject to performance-based vesting and expire seven years from the date of grant or earlier upon termination of continuous
service. Vesting of awards granted under the 2011 Plan still subject to vesting is set forth in the applicable footnote accompanying the entry. All option awards granted pursuant to our 2011 Plan subject to time-based vesting have vested in part,
and the remaining unvested portion will vest as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the vesting commencement date. All option awards
granted under our 2011 Plan subject to performance-based vesting have either been cancelled or are vested in full. Option awards granted on or after May&nbsp;28, 2014, and prior to May&nbsp;24, 2017, were issued under our 2014 Plan and are either
subject to time-based vesting or were subject to performance-based vesting and expire seven years from the date of grant or earlier upon termination of continuous service. Vesting of awards granted under the 2014 Plan is set forth in the applicable
footnote accompanying the entry. Option awards granted pursuant to our 2014 Plan subject to time-based vesting vest as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the <FONT
STYLE="white-space:nowrap">one-year</FONT> anniversary of the vesting commencement date and thereafter as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly
anniversary of the vesting commencement date. Option awards granted pursuant to our 2014 Plan subject to performance-based vesting are vested in full. Option awards granted on or after May&nbsp;24, 2017 were issued under our 2017 Plan and are
subject to time-based vesting and expire seven years from the date of grant or earlier upon termination of continuous service. Vesting of awards granted under the 2017 Plan is set forth in the applicable footnote accompanying the entry. Option
awards granted pursuant to our 2017 Plan subject to time-based vesting vest as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the
<FONT STYLE="white-space:nowrap">one-year</FONT> anniversary of the vesting commencement date and thereafter as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly
anniversary of the vesting commencement date. The 2017 Plan also provides for the grant of option awards subject to performance-based vesting, but as of December&nbsp;29, 2017, no such awards have been granted. Vesting of all options issued to our
Named Executive Officers are subject to acceleration as described under the caption &#147;Potential Payments Upon Termination or Change in Control&#148; below. </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">RSU awards granted prior to May&nbsp;28, 2014 were issued under our 2011 Plan, RSU awards granted on or after May&nbsp;28, 2014 and prior to May&nbsp;24, 2017 were issued under our 2014 Plan, and
RSU awards granted on or after May&nbsp;24, 2017 were issued under our 2017 Plan. RSU awards generally vest as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the RSU award on the first
established RSU vesting date following the one year anniversary of the grant date and thereafter as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the RSU award on each anniversary of the
first established RSU vesting date following the one year anniversary of the grant date, until fully-vested. We have established February 15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP>, May
15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP>, August&nbsp;15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> and November&nbsp;15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> as RSU vesting dates. Vested shares will be
delivered to the Named Executive Officer on the applicable vesting date, provided that delivery may be delayed pursuant to the terms of the award agreement. Vesting of all RSU awards issued to our Named Executive Officers is subject to acceleration
as described under the caption &#147;Potential Payments Upon Termination or Change in Control&#148; below. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">53</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">

<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">For purposes of determining market value, we assumed a stock price of $30.40, the closing sale price per share of our common stock on December&nbsp;29, 2017, the last business day of our last
fiscal year. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(4)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final
vesting date of September&nbsp;16, 2019 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(5)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the <FONT STYLE="white-space:nowrap">one-year</FONT>
anniversary of the grant date and thereafter as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final vesting date of
February&nbsp;11, 2020 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(6)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the <FONT STYLE="white-space:nowrap">one-year</FONT>
anniversary of the grant date and thereafter as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final vesting date of
September&nbsp;22, 2020 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(7)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">RSUs vest as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the RSU award on each November
15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> with a final vesting date of November&nbsp;15, 2020 (assuming that such RSUs are not accelerated). </FONT></TD></TR></TABLE>
<P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(8)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final
vesting date of July&nbsp;15, 2019 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(9)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final
vesting date of February&nbsp;10, 2018 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(10)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the <FONT STYLE="white-space:nowrap">one-year</FONT>
anniversary of the grant date and thereafter as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final vesting date of
September&nbsp;26, 2020 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(11)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Option vests as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on the <FONT STYLE="white-space:nowrap">one-year</FONT>
anniversary of the grant date and thereafter as to 1/48<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the option on each monthly anniversary of the grant date with a final vesting date of
October&nbsp;3, 2021 (assuming that such options are not accelerated). </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:8pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(12)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">RSUs vest as to 1/4<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> of the original number of shares subject to the RSU award on each November
15<SUP STYLE="font-size:85%; vertical-align:top">th</SUP> with a final vesting date of November&nbsp;15, 2021 (assuming that such RSUs are not accelerated). </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Option Exercises and Stock Vested </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table includes certain
information with respect to stock options exercised and stock awards that vested during the fiscal year ended December&nbsp;29, 2017. </FONT></P> <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT
 COLOR="#3f3f3f"><B>Options Exercised and Stock Vested in Fiscal 2017 </B></FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="56%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Option Awards</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Stock Awards</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number of<BR>Shares<BR>Acquired&nbsp;on<BR>Exercise(#)</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Value</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Realized&nbsp;on<BR>Exercise($)(1)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Number of</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Shares</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Acquired&nbsp;on</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Vesting(#)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Value</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Realized&nbsp;on</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Vesting($)(2)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael M. Morrissey, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">970,449</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">19,617,032</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">15,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">371,250</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">262,508</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">3,704,392</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">123,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">2,313,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">5,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">123,750</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">182,302</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">3,222,445</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">4,063</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">100,559</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">185,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">2,110,367</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">4,063</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #ff4c00">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00" ALIGN="right"><FONT COLOR="#3f3f3f">100,559</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #ff4c00"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;Value Realized on Exercise&#148; reflects the price at which the shares acquired upon exercise (the closing market price of our common stock on the exercise date) of the stock options were
sold, net of the exercise price for acquiring the shares. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">&#147;Value Realized on Vesting&#148; reflects the product of the fair market value of our common stock on the applicable vesting date multiplied by the number of units vested and does not
necessarily reflect proceeds actually received by the Named Executive Officers. </FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">54</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Potential Payments Upon Termination or Change in Control </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">Potential Payments Upon Termination or Change in Control </FONT></P>
<P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Change in Control and Severance
Benefit Plan</B> </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In December&nbsp;2005, the Board, upon recommendation of the Compensation Committee, adopted a Change in Control and
Severance Benefit Plan that provides for certain severance benefits to our officers in connection with specified termination events. Eligible plan participants may include any employee having a rank of vice president or above, which includes the
Named Executive Officers. We amended our Change in Control and Severance Benefit Plan in December 2008 and again in December 2010 to bring the plan into compliance with Section&nbsp;409A of the Code and other rules governing such plans. We further
amended our Change in Control and Severance Benefit Plan in September 2017 to, among other compliance-related changes, increase the cash payments and COBRA benefits for plan participants, including our Named Executive Officers, following termination
events not in connection with a change in control. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">If a Named Executive Officer&#146;s employment terminates due to an involuntary
termination without cause or a constructive termination, or Covered Termination, during a period starting one month prior to and ending 13 months following a change in control, or a Change in Control Termination, then the Named Executive Officer
would be entitled to the following benefits under the plan: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">a cash payment paid in installments pursuant to our regularly scheduled payroll periods equal to the sum of the Named Executive Officer&#146;s base salary and target bonus for (i)&nbsp;18 months
for Named Executive Officers (other than the Chief Executive Officer) and (ii)&nbsp;24 months for the Chief Executive Officer; </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">the vesting of up to all of the Named Executive Officer&#146;s options and RSUs will accelerate in full, and the exercise period of such options will be extended to the later of: (i)&nbsp;12 months
after the later of (x)&nbsp;the participant&#146;s termination date, or (y)&nbsp;the change in control; and (ii)&nbsp;the post-termination exercise period provided for in the applicable option agreement; the plan also provides that any reacquisition
or repurchase rights held by us in respect of common stock issued or issuable pursuant to any stock awards granted under any of our equity incentive plans shall lapse; </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">payment of COBRA premiums, or the cash equivalent thereof, for any health, dental or vision plan sponsored by Exelixis for a period of up to (i)&nbsp;18 months for Named Executive Officers (other
than the Chief Executive Officer) and (ii)&nbsp;24 months for the Chief Executive Officer; and </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">payment of outplacement services for (i)&nbsp;18 months for Named Executive Officers (other than the Chief Executive Officer), subject to a $30,000 limit and (ii)&nbsp;24 months for the Chief
Executive Officer, subject to a $50,000 limit. </FONT></TD></TR></TABLE> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">In the event of a Covered Termination of a Named Executive Officer that is
not also a Change in Control Termination, such Named Executive Officer would be entitled to receive a cash severance benefit under the plan equal to 12 months of base salary paid in installments pursuant to our regularly scheduled payroll periods.
In such circumstances, we would also pay for a period of up to 12 months such Named Executive Officer&#146;s COBRA premiums, or the cash equivalent thereof, for any health, dental or vision plan that we sponsored and that the Named Executive Officer
is enrolled in. However, such Named Executive Officer would not be entitled to any vesting acceleration benefits by virtue of such termination. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">The payments and benefits described above are subject to certain reductions and offsets if, for example, the Named Executive Officer received other severance benefits from us pursuant to a written employment agreement. In addition,
if any of the severance benefits payable under the plan would constitute a &#147;parachute payment&#148; subject to the excise tax imposed by Section&nbsp;4999 of the Code, a Named Executive Officer may receive a reduced amount of the affected
severance benefits, The plan does not provide for the gross up of any excise taxes imposed by Section&nbsp;4999 of the Code. No Named Executive Officer would receive benefits under the plan if (i)&nbsp;the Named Executive Officer has entered into an
individually negotiated employment agreement that provides for severance or change in control benefits, (ii)&nbsp;the Named Executive Officer voluntarily terminates employment with us to accept employment with another entity that is controlled by us
or is otherwise affiliated with us or (iii)&nbsp;the Named Executive Officer does not confirm in writing that he or she is subject to agreements with us relating to proprietary and confidential information. In addition, as a general matter, to be
eligible to receive benefits under the plan and if requested by Exelixis, a Named Executive Officer must execute a general waiver and release of claims, and such release must become effective in accordance with its terms. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Treatment of Equity Awards</B> </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Pursuant to our 2000 Plan, 2011 Plan, 2014 Plan and 2017 Plan, in the event of an asset sale, merger or consolidation in which we are not the
surviving corporation, or a reverse merger in which we are the surviving corporation but our common stock is converted by virtue of the merger into other property, then any surviving or acquiring corporation may assume
</FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">55</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">
outstanding stock awards or substitute similar stock awards for those under the plan. If any surviving or acquiring corporation refuses to assume such outstanding stock awards or substitute
similar stock awards, stock awards held by participants whose service has not terminated will be accelerated in full. In addition, if any person, entity or group acquires beneficial ownership of more than 50% of our combined voting power, then stock
awards held by participants whose service has not terminated will be accelerated in full. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table sets forth the potential
severance payments and benefits under our Change in Control and Severance Benefit Plan to which a Named Executive Officer would be entitled in connection with specified termination events, as if such Named Executive Officers&#146; employment
terminated as of December&nbsp;29, 2017, the last day of our last fiscal year. In addition, the table sets forth the amounts to which such Named Executive Officers would be entitled under our equity plans either (i)&nbsp;in connection with a change
in control transaction in which the successor corporation did not assume or substitute outstanding stock awards, or (ii)&nbsp;an entity or group acquired more than 50% of our combined voting power, in each case, as of December&nbsp;29, 2017. There
are no other agreements, arrangements or plans that entitle any of the above-mentioned Named Executive Officers to severance, perquisites or other enhanced benefits upon termination of employment, other than certain extensions of the termination
date to avoid violation of registration requirements under the Securities Act of 1933, as amended, or for such Named Executive Officer&#146;s death or disability. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><B>Potential Payments Table</B> </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The following table shows the potential payments upon termination of employment or a change in control for the Named Executive Officers. The table
assumes that the triggering event took place on December&nbsp;29, 2017, the last day of our 2017 fiscal year. </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="center"><FONT COLOR="#3f3f3f"><B>Potential Payments Upon Termination or Change in Control Table </B></FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="31%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD WIDTH="29%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" ROWSPAN="2" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ROWSPAN="2"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Benefit</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Change&nbsp;in&nbsp;Control&nbsp;and&nbsp;Severance</FONT></B></FONT><br><FONT COLOR="#ffffff"><B><FONT
 COLOR="#ffffff">Benefit Plan</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Equity Plans</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Involuntary</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Without</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Cause&nbsp;or</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Constructive</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination&nbsp;in</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Connection</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">with&nbsp;a Change</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">of&nbsp;Control&nbsp;($)(1)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Involuntary</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Without</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Cause or</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Constructive</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination&nbsp;Not</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">in&nbsp;Connection</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">with a Change</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">in Control ($)(2)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Certain</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Change of</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Control</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Transactions</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">without</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)(3)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Michael&nbsp;M.&nbsp;Morrissey,&nbsp;Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Base&nbsp;Salary</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,802,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">901,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Bonus</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">1,351,500</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Vesting&nbsp;Acceleration<SUP STYLE="font-size:85%; vertical-align:top">(4)</SUP></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">17,830,288</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">17,830,288</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">COBRA Payments</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">60,672</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">30,336</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Outplacement Services</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">50,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<B>Benefit
Total</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>21,094,460</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>931,336</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>17,830,288</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Gisela M. Schwab, M.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Base Salary</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">954,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">636,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Bonus</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">477,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Vesting&nbsp;Acceleration<SUP STYLE="font-size:85%; vertical-align:top">(4)</SUP></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,583,703</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">8,583,703</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">COBRA Payments</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">51,019</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">34,013</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Outplacement Services</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">30,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<B>Benefit
Total</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>10,095,722</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>670,013</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>8,583,703</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Christopher J. Senner</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Base Salary</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">850,500</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">567,000</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Bonus</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">382,725</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Vesting&nbsp;Acceleration<SUP STYLE="font-size:85%; vertical-align:top">(4)</SUP></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10,482,528</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">10,482,528</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">COBRA Payments</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">45,504</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">30,336</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Outplacement&nbsp;Services</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">30,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<B>Benefit
Total</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>11,791,257</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>597,336</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>10,482,528</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD></TR></TABLE>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">56</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

</DIV></Center>


<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">


<Center><DIV STYLE="width:8.5in" align="left">
 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Potential Payments Upon Termination or Change in Control </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="32%"></TD>
<TD VALIGN="bottom" WIDTH="4%"></TD>
<TD WIDTH="30%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD></TD>
<TD></TD>
<TD VALIGN="bottom" WIDTH="3%"></TD></TR>

<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom" ROWSPAN="2" STYLE="BORDER-LEFT:1px solid #ff4c00; padding-left:8pt">
<P STYLE=" margin-top:0pt ; margin-bottom:0pt; text-indent:0.50em; font-size:8pt; font-family:arial"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Name</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" ROWSPAN="2"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Benefit</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="6" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Change&nbsp;in&nbsp;Control&nbsp;and&nbsp;Severance</FONT></B></FONT><br><FONT COLOR="#ffffff"><B><FONT
 COLOR="#ffffff">Benefit Plan</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right" STYLE="border-bottom:1.00px solid #ffffff"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Equity Plans</FONT></B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>
<TR BGCOLOR="#ff4c00" STYLE="page-break-inside:avoid ; font-family:arial; font-size:8pt">
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Involuntary</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Without</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Cause&nbsp;or</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Constructive</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination&nbsp;in</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Connection</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">with&nbsp;a Change</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">of&nbsp;Control&nbsp;($)(1)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Involuntary</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Without</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Cause or</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Constructive</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination&nbsp;Not</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">in&nbsp;Connection</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">with a Change</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">in Control ($)(2)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" COLSPAN="2" ALIGN="right"> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Certain</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Change of</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Control</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Transactions</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">without</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">Termination</FONT></B></FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:arial" ALIGN="right"><FONT COLOR="#ffffff"><B><FONT COLOR="#ffffff">($)(3)</FONT></B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Jeffrey J. Hessekiel, J.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Base Salary</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">766,568</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">511,045</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Bonus</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">344,955</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Vesting&nbsp;Acceleration<SUP STYLE="font-size:85%; vertical-align:top">(4)</SUP></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">5,771,678</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">5,771,678</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">COBRA Payments</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">28,647</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">19,098</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Outplacement Services</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">30,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<B>Benefit
Total</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>6,941,848</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>530,143</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>5,771,678</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Peter Lamb, Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Base Salary</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">714,150</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">476,100</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Bonus</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">321,368</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">Vesting&nbsp;Acceleration<SUP STYLE="font-size:85%; vertical-align:top">(4)</SUP></FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">6,329,575</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">6,329,575</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">COBRA Payments</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">17,729</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">11,819</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">Outplacement Services</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">30,000</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1px solid #b2b2b2">&nbsp;&nbsp;</TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2" ALIGN="right"><FONT COLOR="#3f3f3f">&#151;</FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1px solid #b2b2b2"><FONT COLOR="#3f3f3f">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:arial; font-size:10pt">
<TD VALIGN="top" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.40em; text-indent:-1.00em; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;<B>Benefit
Total</B></FONT></P></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>7,412,822</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>487,919</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE=" BORDER-BOTTOM:1.00pt solid #3f3f3f">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD>
<TD VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f" ALIGN="right"><FONT COLOR="#3f3f3f"><B>6,329,575</B></FONT></TD>
<TD NOWRAP VALIGN="bottom" STYLE="BORDER-BOTTOM:1.00pt solid #3f3f3f"><FONT COLOR="#3f3f3f"><B>&nbsp;</B></FONT></TD></TR>
</TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(1)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">These benefits would be payable under the Change in Control and Severance Benefit Plan if the involuntary termination without cause or constructive termination occurred during a period starting one
month prior to and ending 13 months following the change in control. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(2)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">These benefits would be payable under the Change in Control and Severance Benefit Plan if the involuntary termination without cause occurred more than one month before the change in control or if
the involuntary termination without cause or a constructive termination occurred more than 13 months following the change in control. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(3)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">These benefits would be payable under the 2000 Plan and/or the 2011 Plan and/or the 2014 Plan and/or the 2017 Plan if either (i)&nbsp;a successor corporation does not assume outstanding stock
awards in a change of control transaction or (ii)&nbsp;a person, entity or group acquires beneficial ownership of more than 50% of our combined voting power, and, in each case, the Named Executive Officers do not terminate employment in connection
with such a transaction or event. </FONT></TD></TR></TABLE> <P STYLE="font-size:3pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:arial; font-size:10pt" BORDER="0" CELLPADDING="0" CELLSPACING="0" WIDTH="100%">
<TR style = "page-break-inside:avoid">
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">(4)</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">Assumes that the triggering event occurred on December&nbsp;29, 2017, the last day of our last fiscal year, when the closing sale price per share of our common stock was $30.40. The amount of the
vesting acceleration is determined by: (i)&nbsp;aggregating for all accelerated options, the amount equal to (A)&nbsp;the excess, if any, of $30.40 over the relevant exercise price of the option, multiplied by (B)&nbsp;the number of shares
underlying unvested options at such exercise price as of December&nbsp;29, 2017; and (ii)&nbsp;aggregating for all accelerated RSUs, the amount equal to (X) $30.40 multiplied by (Y)&nbsp;the number of shares underlying the unvested RSUs. There can
be no assurance that a similar triggering event would produce the same or similar results as those estimated if such event occurs on any other date or at a time when our closing sale price is different. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:14pt; font-family:arial"><FONT COLOR="#3f3f3f">CEO Pay Ratio </FONT></P> <P STYLE="line-height:4.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt solid #ff4c00">&nbsp;</P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">We believe that we provide fair and equitable compensation to our employees through a combination of competitive base pay, incentives, retirement
plans and other benefits. In accordance with Item 402(u) of Regulation <FONT STYLE="white-space:nowrap">S-K,</FONT> promulgated by the Dodd Frank Act, we determined the ratio of: (a)&nbsp;the annual total compensation of our Chief Executive Officer;
to (b)&nbsp;the median of the annual total compensation of all of our employees, except for our Chief Executive Officer, both calculated in accordance with the requirements of Item 402(c)(2)(x) of Regulation
<FONT STYLE="white-space:nowrap">S-K.</FONT> </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">To determine the median of the annual total compensation of all of our employees, except
for our Chief Executive Officer, we used the following methodology: </FONT></P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">To identify our employee population, we used tax and payroll records to determine all full-time, part-time, temporary and seasonal employees, excluding our Chief Executive Officer, who were
employed as of October&nbsp;31, 2017. </FONT></TD></TR></TABLE> <P STYLE="font-size:6pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">57</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">To identify the median of the annual total compensation of all of our employees from our employee population, we calculated each employee&#146;s &#147;target total direct compensation,&#148; which
consists of: (i)&nbsp;fiscal 2017 base salary (using a reasonable estimate of the hours worked and overtime actually paid during fiscal 2017 for hourly employees); (ii)&nbsp;target cash bonus; and (iii)&nbsp;the grant date fair value of any equity
awards granted during fiscal 2017 (using the same methodology that we use for estimating the value of the equity awards granted to our Named Executive Officers and reported in our Summary Compensation Table). </FONT></TD></TR></TABLE>
<P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD WIDTH="3%">&nbsp;</TD>
<TD WIDTH="4%" VALIGN="top" ALIGN="left"><FONT COLOR="#3f3f3f">&#155;</FONT><FONT COLOR="#ff4c00">&#155;</FONT></TD>
<TD ALIGN="left" VALIGN="top"><FONT COLOR="#3f3f3f">In making this determination, we annualized the base salary and target cash bonus for employees who were employed by us for less than the entirety of fiscal 2017. </FONT></TD></TR></TABLE>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Because the median employee we initially identified had anomalous compensation characteristics, we substituted another employee with substantially
similar compensation to the originally identified median employee during fiscal 2017. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Once our representative median employee was
identified in the manner described above, we calculated the annual total compensation of the representative median employee using the same methodology that we used to determine the annual total compensation of our Chief Executive Officer, as
reported in the Summary Compensation Table included in this proxy statement. For fiscal 2017, the median of the annual total compensation of our employees (other than our Chief Executive Officer) was $275,254 and the annual total compensation of our
Chief Executive Officer, as reported in the Summary Compensation Table included in this Proxy Statement, was $9,439,583. Based on this information, the ratio of the annual total compensation of our Chief Executive Officer to the median of the annual
total compensation of all employees was 34 to 1. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">This pay ratio represents our reasonable estimate calculated in a manner consistent
with Item 402(u) of Regulation <FONT STYLE="white-space:nowrap">S-K</FONT> and applicable guidance, which provide significant flexibility in how companies identify the median employee. Each company may use a different methodology and make different
assumptions particular to that company. As a result, and as explained by the SEC when it adopted these rules, in considering the pay ratio disclosure, stockholders should keep in mind that the rule was not designed to facilitate comparisons of pay
ratios among different companies, even companies within the same industry, but rather to allow stockholders to better understand and assess each particular company&#146;s compensation practices and pay ratio disclosures. Neither the Compensation
Committee nor our management used our fiscal 2017 Chief Executive Officer to median employee pay ratio in making compensation decisions. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">58</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">Compensation of Executive Officers&nbsp;</FONT><FONT
STYLE="font-family:arial" COLOR="#ff4c00">|</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;Compensation Committee Report </FONT></P> <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">COMPENSATION COMMITTEE REPORT </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f"><I>The material in this report is not &#147;soliciting material,&#148; is not deemed &#147;filed&#148; with the Securities and Exchange Commission
and is not deemed to be incorporated by reference in any filing of Exelixis under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, as amended, whether made before or after the date hereof and irrespective of any
general incorporation language in any such filing. </I></FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Compensation Committee of the Board of Directors of Exelixis, Inc.,
consisting solely of independent directors, has reviewed and discussed with management the Compensation Discussion and Analysis contained in this Proxy Statement and, based on this review and discussion, the Compensation Committee recommended to the
Board of Directors that the Compensation Discussion and Analysis be included in this Proxy Statement and incorporated into our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the year ended December&nbsp;29, 2017. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Compensation Committee: </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Charles
Cohen, Chairman </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Carl B. Feldbaum </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT
 COLOR="#3f3f3f">Vincent T. Marchesi </FONT></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Julie A. Smith </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Lance Willsey </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">59</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">COMPENSATION COMMITTEE INTERLOCKS AND INSIDER PARTICIPATION </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">During 2017, the Compensation Committee comprised Drs. Cohen, Marchesi and Willsey, Mr.&nbsp;Feldbaum and Ms.&nbsp;Smith. None of the members of
the Compensation Committee during 2017 has at any time been an officer or employee of Exelixis, except that Dr.&nbsp;Cohen served as our acting Chief Scientific Officer from December 1995 to April 1997, and was named an officer of one of our former
subsidiaries from 2001 through March 2005, for which he did not receive any compensation. No interlocking relationship exists between the Board or Compensation Committee and the board of directors or compensation committee of any other company, nor
has any interlocking relationship existed in the past. </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">CERTAIN RELATIONSHIPS AND RELATED PARTY TRANSACTIONS </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Board recognizes that related party transactions can present a heightened risk of potential or actual conflicts of interests. The Board
adopted a written Statement of Policy with respect to transactions entered into with related parties. Under this policy, the Audit Committee has been tasked with responsibility to review and approve related party transactions. The policy provides
that management shall present related party transactions to the Audit Committee for approval. The policy does not prevent management from entering into any related party transaction without prior approval of the Audit Committee, so long as such
related party transaction is thereafter presented to the Audit Committee for ratification. If ratification is not forthcoming, then management shall make all reasonable efforts to cancel or annul such transaction. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Under the policy, a &#147;related party&#148; includes: any senior officer (including each executive officer or officer subject to Section&nbsp;16
of the Securities Exchange Act of 1934, as amended) or director of Exelixis; a person who is an immediate family member of a senior officer, director or director nominee; a security holder who is known to own of record or beneficially more than 5%
percent of any class of our securities; a person who is an immediate family member of such security holder; or an entity which is owned or controlled by one of the aforementioned persons, or an entity in which one of the aforementioned persons has a
substantial ownership interest in or control over such entity. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">All related party transactions shall be disclosed in our applicable
filings with the SEC as required under SEC rules. </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">SECTION 16(a) BENEFICIAL OWNERSHIP REPORTING COMPLIANCE </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Section&nbsp;16(a) of the Securities Exchange Act of 1934, as amended, requires our directors and executive officers and persons who own more than
ten percent of a registered class of our equity securities to file with the SEC initial reports of ownership and reports of changes in ownership of our common stock and other equity securities of Exelixis. Officers, directors and greater than ten
percent stockholders are required by SEC regulation to furnish us with copies of all Section&nbsp;16(a) forms they&nbsp;file. </FONT></P> <P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">To our
knowledge, based solely on a review of the copies of such reports furnished to us and written representations that no other reports were required, during the fiscal year ended December&nbsp;29, 2017, all Section&nbsp;16(a) filing requirements
applicable to our officers, directors and greater than ten percent beneficial owners were complied with, except as follows: certain shares of our common stock held by Mr.&nbsp;Haley were inadvertently omitted from Mr.&nbsp;Haley&#146;s&nbsp;Form 3,
originally filed on December&nbsp;21, 2016,&nbsp;and the number of shares beneficially owned by Mr.&nbsp;Haley was corrected in a subsequent Form 5 filing for the fiscal year ended December&nbsp;29, 2017. </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT STYLE="font-family:arial" COLOR="#ff4c00">60</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f">&nbsp;&nbsp;&nbsp;&nbsp;Exelixis, Inc. </FONT></P>

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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">HOUSEHOLDING OF PROXY MATERIALS </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The SEC has adopted rules that permit companies and intermediaries (e.g., brokers, banks and other fiduciaries) to satisfy the delivery
requirements for Notices of Internet Availability of Proxy Materials or other Annual Meeting materials with respect to two or more stockholders sharing the same address by delivering a single Notice or other Annual Meeting materials addressed to
those stockholders. This process, which is commonly referred to as &#147;householding,&#148; potentially means extra convenience for stockholders and cost savings for companies. </FONT></P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">This year, a number of brokers with account holders who are our stockholders will be householding proxy materials. A single Notice will be
delivered to multiple stockholders sharing an address unless contrary instructions have been received from the affected stockholders. Once you have received notice from your broker that they will be householding communications to your address,
householding will continue until you are notified otherwise or until you revoke your consent. If, at any time, you no longer wish to participate in householding and would prefer to receive a separate Notice, please notify your broker or direct your
written request to Investor Relations, Exelixis, Inc., 210 East Grand Avenue, South San Francisco, California 94080 or contact Exelixis, Inc., Investor Relations at <FONT STYLE="white-space:nowrap">(650)&nbsp;837-7000.</FONT> Stockholders who
currently receive multiple copies of the Notice at their address and would like to request householding of their communications should contact their broker. </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">ANNUAL REPORT ON FORM <FONT STYLE="white-space:nowrap">10-K</FONT> </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">A copy of our Annual Report on Form <FONT STYLE="white-space:nowrap">10-K</FONT> for the fiscal year ended December&nbsp;29, 2017, including the
consolidated financial statements, schedules and list of exhibits, and any particular exhibit specifically requested, is available without charge upon written request to: Investor Relations, Exelixis, Inc., 210 East Grand Avenue, South San
Francisco, California 94080. </FONT></P> <P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:18pt; font-family:arial"><FONT COLOR="#ff4c00">OTHER MATTERS </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">The Board knows of no other matters that will be presented for consideration at the Annual Meeting. If any other matters are properly brought
before the meeting, it is the intention of the persons named in the accompanying proxy to vote on such matters in accordance with their best judgment. </FONT></P>
<P STYLE="margin-top:18pt; margin-bottom:0pt; margin-left:68%; text-indent:-2%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">By Order of the Board of Directors </FONT></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt; margin-left:68%; text-indent:-2%">


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 </P> <P STYLE="margin-top:4pt; margin-bottom:0pt; margin-left:68%; text-indent:-2%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">JEFFREY J. HESSEKIEL </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:68%; text-indent:-2%; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">Executive Vice President and General Counsel </FONT></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">South San Francisco, California </FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial"><FONT COLOR="#3f3f3f">April&nbsp;12, 2018 </FONT></P>
 <p STYLE="margin-top:0pt;margin-bottom:0pt ; font-size:8pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:arial" ALIGN="right"><FONT COLOR="#3f3f3f">2018 Proxy
Statement&nbsp;&nbsp;&nbsp;&nbsp;</FONT><FONT STYLE="font-family:arial" COLOR="#ff4c00">61</FONT><FONT STYLE="font-family:arial" COLOR="#3f3f3f"> </FONT></P>

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<B>www.investorvote.com/EXEL</B></P> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:3.00em; text-indent:-1.00em; font-size:8pt; font-family:Times New Roman">&#149;&#8194;&#8202;Or scan the QR code with your smartphone</P>
<P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:3.00em; text-indent:-1.00em; font-size:8pt; font-family:Times New Roman">&#149;&#8194;&#8202;Follow the steps outlined on
the secure website</P></TD>
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<TD VALIGN="top" COLSPAN="3"> <P STYLE="font-size:6pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman"><B>Vote by telephone</B></P>
<P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.63em; text-indent:-1.00em; font-size:8pt; font-family:Times New Roman">&#149;&#8194;&#8202;Call toll free 1-800-652-VOTE
(8683) within the USA, US territories &amp; Canada on a touch tone telephone</P> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.63em; text-indent:-1.00em; font-size:8pt; font-family:Times New Roman">&#149;&#8194;&#8202;Follow the instructions provided by the recorded message</P></TD>
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<TD VALIGN="top"> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman">Using a <B><U>black ink</U></B> pen, mark your votes with an <B>X</B>
as shown in this example. Please do not write outside the designated areas.</P></TD>
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<TD VALIGN="top"><FONT STYLE="font-size:24pt">&#9746;</FONT><FONT STYLE="font-size:20pt">&nbsp;&nbsp;</FONT></TD>
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<IMG SRC="g489684img004a.jpg" ALT="LOGO">
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<TD VALIGN="top" STYLE="BORDER-BOTTOM:1px dashed #000000"> <P STYLE="font-size:4pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman" ALIGN="center"><B></B><FONT
STYLE="FONT-FAMILY:'WINGDINGS 3'">&#113;</FONT><B></B><B>&nbsp;&nbsp;IF YOU HAVE NOT VOTED VIA THE INTERNET <U>OR</U> TELEPHONE, FOLD ALONG THE PERFORATION, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE.&nbsp;&nbsp;</B><FONT
STYLE="FONT-FAMILY:'WINGDINGS 3'">&#113;</FONT><B></B><B></B></P> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:1pt" align="left">&nbsp;</P></TD>
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<TD VALIGN="middle" BGCOLOR="#000000"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman"><FONT COLOR="#FFFFFF"><B>&nbsp;A&nbsp;</B></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="middle" ROWSPAN="2"> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:5.80em; text-indent:-5.80em; font-size:8pt; font-family:Times New Roman"><B>Proposals &#151; The Board of Directors recommends a vote <U>FOR</U> all the
nominees listed in Proposal 1 and <U>FOR</U> Proposals 2 and 3.</B></P> <P STYLE="font-size:8pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD>
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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:10pt">
<TD VALIGN="middle" COLSPAN="3"><FONT STYLE="font-size:8pt">1. To elect the three Class I nominees for director named in the accompanying Proxy Statement to hold office until the 2021 Annual Meeting of Stockholders</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom" ALIGN="right"><FONT STYLE="font-size:25pt"><B>+</B></FONT></TD></TR>
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<TD VALIGN="top"></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>For</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>Against</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>Abstain</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>For</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>For</B></TD>
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<TD VALIGN="top"> <P STYLE="font-size:4pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;01&nbsp;-&nbsp;Charles&nbsp;Cohen,&nbsp;Ph.D.</FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></P></TD>
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<TD VALIGN="top"> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></P></TD>
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<TD VALIGN="top"> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" NOWRAP> <P STYLE="font-size:4pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Times New Roman"><FONT STYLE="white-space:nowrap">02&nbsp;-&nbsp;George</FONT>
Poste, DVM,</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Ph.D., FRS</P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></P></TD>
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<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></P></TD>
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<TD VALIGN="top"> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></P></TD>
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<TD VALIGN="top"> <P STYLE="font-size:4pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman">03&nbsp;-&nbsp;Jack L. Wyszomierski</P></TD>
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<TD VALIGN="bottom">&nbsp;</TD>
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<TD VALIGN="bottom" ALIGN="center"><B>For</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>Against</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>Abstain</B></TD>
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<TD VALIGN="bottom" ALIGN="center"><B>&nbsp;Abstain</B></TD></TR>


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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:8pt; font-family:Times New Roman">2.&#8201;To ratify the selection by the Audit Committee of the Board of Directors of Ernst &amp;
Young LLP as Exelixis&#146; independent registered public accounting firm for the fiscal year ending December 28, 2018.</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></TD>
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<TD VALIGN="top" ALIGN="center"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></TD>
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<TD VALIGN="top"> <P STYLE=" margin-top:0pt ; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:8pt; font-family:Times New Roman">3.&#8201;To approve, on an advisory basis, the compensation of Exelixis&#146; named executive
officers, as disclosed in the accompanying Proxy Statement.</P></TD>
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<TD VALIGN="middle" BGCOLOR="#000000"><FONT COLOR="#FFFFFF"><B>&nbsp;B&nbsp;</B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><B>Non-Voting Items</B></TD>
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<TR STYLE="page-break-inside:avoid ; font-family:Times New Roman; font-size:8pt">
<TD VALIGN="top" NOWRAP><B>Change of Address</B> &#151; Please print your new address below.</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"><B>Comments</B> &#151; Please print your comments below.</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"><B>Meeting Attendance</B></TD>
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<TD VALIGN="top" STYLE="BORDER:1px solid #000000; padding-left:8pt"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"></TD>
<TD VALIGN="bottom" STYLE=" BORDER-LEFT:1px solid #000000; BORDER-TOP:1px solid #000000; BORDER-BOTTOM:1px solid #000000">&nbsp;</TD>
<TD VALIGN="bottom" STYLE="BORDER-TOP:1px solid #000000; BORDER-RIGHT:1px solid #000000; BORDER-BOTTOM:1px solid #000000"><FONT SIZE="1">&nbsp;</FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top">Mark the box to the right if you plan to attend the Annual Meeting.</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"><FONT STYLE="font-size:20pt"><FONT STYLE="font-size:16pt">&#9744;</FONT></FONT></TD></TR>
</TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" BGCOLOR="#000000"><FONT COLOR="#FFFFFF"><B>&nbsp;C&nbsp;</B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="top"><B>Authorized Signatures &#151; This section must be completed for your vote to be counted. &#151; Date and Sign Below</B></TD>
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<TD VALIGN="middle" COLSPAN="3"> <P STYLE="font-size:2pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt; margin-bottom:1pt; font-size:8pt; font-family:Times New Roman"><B>NOTE: Please sign as name appears hereon. Joint
owners should each sign. When signing as attorney, executor, administrator, trustee or guardian, please give full title as such.</B></P></TD>
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</TABLE></DIV> <P STYLE="margin-top:6pt; margin-bottom:0pt; text-indent:17%; font-size:8pt; font-family:Times New Roman">02TAYA </P>

<p Style='page-break-before:always'>
<HR  SIZE="3" style="COLOR:#999999" WIDTH="100%" ALIGN="CENTER">

 <P STYLE="margin-top:120pt; margin-bottom:0pt; margin-left:8%; font-size:10pt; font-family:Times New Roman"><B>Important notice regarding the Internet availability of proxy materials for the 2018 Annual
Meeting of Stockholders. </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:8%; font-size:10pt; font-family:Times New Roman">The Proxy Statement and the 2017 Annual Report to Stockholders are available at: </P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:8%; font-size:10pt; font-family:Times New Roman"><B><U>http://exel-annualstockholdermeeting.com</U></B> </P> <P STYLE="font-size:120pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:6pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B></B><FONT STYLE="FONT-FAMILY:'WINGDINGS 3'">&#113;</FONT><B></B><B> IF YOU HAVE NOT VOTED VIA THE INTERNET <U>OR</U> TELEPHONE, FOLD ALONG
THE PERFORATION, DETACH AND RETURN THE BOTTOM PORTION IN THE ENCLOSED ENVELOPE. </B><FONT STYLE="FONT-FAMILY:'WINGDINGS 3'">&#113;</FONT><B></B><B> </B></P> <P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="line-height:1.0pt;margin-top:0pt;margin-bottom:2pt;border-bottom:1.00pt dashed #000000">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt">


<IMG SRC="g489684img006.jpg" ALT="LOGO">
 </P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD VALIGN="top" STYLE="BORDER-TOP:1.50pt solid #000000; BORDER-BOTTOM:1.50pt solid #000000"> <P STYLE="font-size:4pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>Proxy &#151; EXELIXIS, INC.</B></P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD></TR>
</TABLE> <P STYLE="margin-top:24pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>PROXY SOLICITED BY THE BOARD OF DIRECTORS </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>FOR THE ANNUAL MEETING OF STOCKHOLDERS </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman" ALIGN="center"><B>TO BE HELD ON MAY 23, 2018 </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; text-indent:4%; font-size:10pt; font-family:Times New Roman">The undersigned hereby appoints Michael M. Morrissey, Christopher J. Senner and Jeffrey J. Hessekiel, and each of them, as attorneys and
proxies of the undersigned, with full power of substitution, to vote all of the shares of stock of Exelixis, Inc. that the undersigned may be entitled to vote at the Annual Meeting of Stockholders of Exelixis, Inc. to be held at the offices of
Exelixis, Inc. at 210 East Grand Avenue, South San Francisco, CA 94080 on Wednesday, May 23, 2018, at 8:00 a.m. (local time), and at any and all postponements, continuations and adjournments thereof, with all powers that the undersigned would
possess if personally present, upon and in respect of the following matters and in accordance with the following instructions, with discretionary authority as to any and all other matters that may properly come before the meeting. </P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>UNLESS A CONTRARY DIRECTION IS INDICATED, THIS PROXY WILL BE VOTED &#147;FOR&#148; ALL NOMINEES LISTED IN PROPOSAL 1 AND &#147;FOR&#148; PROPOSALS 2 AND 3,
AS MORE SPECIFICALLY DESCRIBED IN THE PROXY STATEMENT. IF SPECIFIC INSTRUCTIONS ARE INDICATED, THIS PROXY WILL BE VOTED IN ACCORDANCE THEREWITH. </B></P>
<P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:10pt; font-family:Times New Roman"><B>(Continued and to be marked, dated and signed, on the other side) </B></P>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
