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Collaboration Agreements (Royalty Revenues under the Collaboration Agreement with GSK) (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 28, 2018 | Dec. 29, 2017 | Jan. 01, 2016
Collaborative Arrangements with Glaxo Smith Kline |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Royalty expense | $ 23,950 | $ 12,413 | $ 4,334
Collaborative Arrangement with GlaxoSmithKline | Collaborative Arrangement with Ipsen |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |
Percent of royalty on net sale | 3.00% |  |

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- Definition Amount of expense related to royalty payments under a contractual arrangement such as payment for mineral and drilling rights and use of technology or intellectual property. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03.3) -URI http://asc.fasb.org/extlink&oid=115205541&loc=SL114868664-224227 + Details
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