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Organization and Summary of Significant Accounting Policies (Impact of Adoption of Topic 606 and Topic 842 on the Consolidated Statements of Operations) (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 28, 2018 | Sep. 28, 2018 | Jun. 29, 2018 | Mar. 30, 2018 | Dec. 29, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 28, 2018 | Dec. 29, 2017 | Dec. 30, 2016
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues | $ 228,602 | $ 225,397 | $ 186,108 | $ 213,719 | $ 120,072 | $ 152,510 | $ 99,008 | $ 80,887 | $ 853,826 | $ 452,477 | $ 191,454
Selling, general and administrative |  |  |  |  |  |  |  |  | 206,366 | 159,362 | 116,145
Total operating expenses |  |  |  |  |  |  |  |  | 414,971 | 286,567 | 219,578
Interest expense |  |  |  |  |  |  |  |  | 0 | (8,679) | (33,060)
Total other income (expense), net |  |  |  |  |  |  |  |  | 13,237 | (7,333) | (42,098)
Income before income taxes |  |  |  |  |  |  |  |  | 452,092 | 158,577 | (70,222)
Income tax benefit (provision) |  |  |  |  |  |  |  |  | 237,978 | (4,350) | 0
Net income (loss) | $ 360,089 | $ 126,630 | $ 87,494 | $ 115,857 | $ 38,489 | $ 81,382 | $ 17,656 | $ 16,700 | $ 690,070 | $ 154,227 | $ (70,222)
Net income per share, basic (in dollars per share) | $ 1.20 | $ 0.42 | $ 0.29 | $ 0.39 | $ 0.13 | $ 0.28 | $ 0.06 | $ 0.06 | $ 2.32 | $ 0.52 | $ (0.28)
Net income per share, diluted (in dollars per share) | $ 1.15 | $ 0.41 | $ 0.28 | $ 0.37 | $ 0.12 | $ 0.26 | $ 0.06 | $ 0.05 | $ 2.21 | $ 0.49 | $ (0.28)
Collaboration revenue |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | $ 234,547 | $ 103,469 | $ 56,079
Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Collaboration revenue |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | 270,429 |  |
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | (35,882) |  |
Income before income taxes |  |  |  |  |  |  |  |  | (35,882) |  |
Income tax benefit (provision) |  |  |  |  |  |  |  |  | (48,325) |  |
Net income (loss) |  |  |  |  |  |  |  |  | $ (84,207) |  |
Net income per share, basic (in dollars per share) |  |  |  |  |  |  |  |  | $ (0.28) |  |
Net income per share, diluted (in dollars per share) |  |  |  |  |  |  |  |  | $ (0.27) |  |
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 | Collaboration revenue |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | $ (35,882) |  |
ASU 2016-02 |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Selling, general and administrative |  |  |  |  |  |  |  |  | 1,204 |  |
Total operating expenses |  |  |  |  |  |  |  |  | 1,204 |  |
Interest expense |  |  |  |  |  |  |  |  | (631) |  |
Total other income (expense), net |  |  |  |  |  |  |  |  | 631 |  |
Income before income taxes |  |  |  |  |  |  |  |  | (573) |  |
Income tax benefit (provision) |  |  |  |  |  |  |  |  | 73 |  |
Net income (loss) |  |  |  |  |  |  |  |  | $ (500) |  |
Net income per share, basic (in dollars per share) |  |  |  |  |  |  |  |  | $ 0.00 |  |
Net income per share, diluted (in dollars per share) |  |  |  |  |  |  |  |  | $ 0.00 |  |
Calculated Under Guidance In Effect Before Topic 606 And Topic 842 [Member] |  |  |  |  |  |  |  |  |  |  |
Revenue, Initial Application Period Cumulative Effect Transition [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | $ 889,708 |  |
Selling, general and administrative |  |  |  |  |  |  |  |  | 205,162 |  |
Total operating expenses |  |  |  |  |  |  |  |  | 413,767 |  |
Interest expense |  |  |  |  |  |  |  |  | 631 |  |
Total other income (expense), net |  |  |  |  |  |  |  |  | 12,606 |  |
Income before income taxes |  |  |  |  |  |  |  |  | 488,547 |  |
Income tax benefit (provision) |  |  |  |  |  |  |  |  | 286,230 |  |
Net income (loss) |  |  |  |  |  |  |  |  | $ 774,777 |  |
Net income per share, basic (in dollars per share) |  |  |  |  |  |  |  |  | $ 2.60 |  |
Net income per share, diluted (in dollars per share) |  |  |  |  |  |  |  |  | $ 2.48 |  |

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