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v3.10.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 28, 2018 | Dec. 29, 2017 | Dec. 30, 2016
Cash flows from operating activities: |  |  |  |
Net income (loss) |  | $ 690,070 | $ 154,227 | $ (70,222)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: |  |  |  |
Depreciation and amortization |  | 4,915 | 1,187 | 1,002
Stock-based compensation |  | 40,626 | 23,938 | 22,912
401(k) matching contributions made in common stock |  | 3,696 | 1,640 | 1,036
Right-of-Use Asset, Amortization |  | 2,854 | 0 | 0
Deferred taxes |  | (244,111) | 0 | 0
Loss on extinguishment of debt |  | 0 | 6,239 | 13,901
Amortization of debt discounts and debt issuance costs |  | 0 | 182 | 8,432
Interest paid in kind |  | 0 | (11,825) | 8,008
Gain on other equity investments |  | (209) | (2,980) | (2,494)
Other |  | (2,358) | (51) | 562
Changes in operating assets and liabilities: |  |  |  |
Trade and other receivables |  | (85,471) | (43,299) | (38,680)
Other receivables |  | (4,410) | 2,460 | 3,362
Inventory, net |  | (3,181) | (3,319) | (722)
Prepaid expenses and other current assets |  | (3,029) | (3,268) | (1,610)
Other long-term assets |  | (1,086) | 430 | 1,077
Accounts payable |  | 856 | 3,010 | 164
Accrued compensation and benefits |  | 11,069 | 739 | 16,705
Accrued clinical trial liabilities |  | (1,618) | 5,718 | (3,940)
Rebates and fees due customers |  | 7,389 | 4,145 | 3,866
Accrued collaboration liabilities |  | (1,555) | 6,928 | (10,938)
Deferred revenue |  | 271 | 13,745 | 256,759
Long-term portion of lease liabilities |  | (1,225) | 14,938 | 0
Other current and long-term liabilities |  | 2,227 | (9,173) | 1,224
Net cash used in operating activities |  | 415,720 | 165,611 | 210,404
Cash flows from investing activities: |  |  |  |
Purchases of property and equipment |  | (33,297) | (21,143) | (1,703)
Proceeds from sale of property and equipment |  | 308 | 164 | 97
Purchases of investments |  | (557,832) | (319,090) | (369,187)
Proceeds from maturities of investments |  | 280,826 | 336,590 | 151,485
Proceeds from sale of investments |  | 11,936 | 37,294 | 2,266
Proceeds from other equity investments |  | 209 | 2,980 | 2,494
Net cash (used in) provided by investing activities |  | (297,850) | 36,795 | (214,548)
Cash flows from financing activities: |  |  |  |
Proceeds from exercise of stock options |  | 12,076 | 17,555 | 25,327
Proceeds from employee stock purchase plan |  | 5,202 | 4,868 | 2,187
Taxes paid related to net share settlement of equity awards |  | (7,574) | (6,563) | (4,108)
Principal payments on financing lease obligation |  | (13) | 0 | 0
Principal repayments of debt |  | 0 | (185,788) | (575)
Payments on conversion of convertible notes |  | 0 | 0 | (7,135)
Net cash provided by financing activities |  | 9,691 | (169,928) | 15,696
Net increase in cash, cash equivalents and restricted cash |  | 127,561 | 32,478 | 11,552
Cash, cash equivalents and restricted cash at beginning of period |  | 188,314 | 155,836 | 144,284
Cash, cash equivalents and restricted cash at end of period |  | 315,875 | 188,314 | 155,836
Supplemental cash flow disclosure: |  |  |  |
Cash paid for interest |  | 0 | 20,460 | 21,044
Cash paid for taxes |  | 10,677 | 538 | 190
Non-cash investing and financing activity: |  |  |  |
Property and equipment deemed to have been acquired in build-to-suit lease |  | 0 | 14,530 | 0
Right-of-use assets obtained in exchange for lease obligations | [1] | 17,180 | 0 | 0
Unpaid liabilities incurred to acquire Property and equipment |  | 802 | 524 | 0
Issuance of common stock in settlement of convertible notes |  | $ 0 | $ 0 | $ 286,925
[1] | Amounts for the year ended December 31, 2018 include the transition adjustment for the adoption of Topic 842.

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- Definition Amount of cash inflow (outflow) from operating activities, including discontinued operations. Operating activity cash flows include transactions, adjustments, and changes in value not defined as investing or financing activities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 25 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3536-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 24 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3521-108585 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3602-108585 + Details
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- Definition Amount of cash outflow to satisfy an employee's income tax withholding obligation as part of a net-share settlement of a share-based award. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3291-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 25 -Paragraph 19A -URI http://asc.fasb.org/extlink&oid=107668666&loc=SL79513924-113897 + Details
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- Definition Amount of cash inflow from maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109979856&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3151-108585 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=109223946&loc=d3e3179-108585 + Details
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