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Collaboration Agreements (Ipsen Collaboration, Narrative) (Details) - Collaborative arrangement with Ipsen |  | 1 Months Ended | 6 Months Ended | 12 Months Ended | 35 Months Ended
--- | --- | --- | --- | --- | ---
Dec. 30, 2017 USD ($) | Feb. 29, 2016 USD ($) | Jun. 29, 2018 USD ($) | Dec. 28, 2018 USD ($) | Dec. 28, 2018 CAD ($) | Dec. 28, 2018 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Collaboration period to achieve specified levels of commercial performance |  |  |  | 10 years | 10 years |
Upfront payment(s) |  | $ 210,000,000 |  |  |  |
Milestone payments earned |  |  |  | $ 140,000,000 |  | $ 275,000,000
Eligible payment from collaboration for development and regulatory milestone achievement under collaborations agreement |  | 84,000,000 |  |  |  |
Maximum amount eligible for commercial milestones under collaborations agreement |  | $ 519,500,000 |  |  |  |
Remaining performance obligation |  |  |  | $ 48,000,000 |  | 48,000,000
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  |  |  | 35.00% | 35.00% |
Net contract liability |  |  |  | $ 13,300,000 |  | $ 13,300,000
Collaborative Arrangement with GlaxoSmithKline |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Percent of royalty on net sale |  |  |  | 3.00% | 3.00% |
Final tier |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Royalty tier |  |  | $ 150,000,000 |  | $ 30,000,000.0 |
Initial |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Percent of royalty on net sale |  |  | 2.00% |  |  |
Second |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Percent of royalty on net sale |  |  | 12.00% |  |  |
Minimum | Final tier |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Percent of royalty on net sale |  |  |  | 22.00% | 22.00% |
Maximum | Final tier |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Percent of royalty on net sale |  |  |  | 26.00% | 26.00% |
EMA Filing Acceptance - HCC | Adjustments Due to the Adoption of Topic 606 | ASU 2014-09 |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |
Milestone payments earned | $ 10,000,000 |  |  |  |  |

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