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Collaboration Agreements (Takeda Collaboration, Narrative) (Details) - USD ($) | 1 Months Ended | 12 Months Ended
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Feb. 28, 2017 | Dec. 28, 2018
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Sales volume period |  | 6 years
Collaborative arrangement with Takeda |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Upfront payment(s) | $ 50,000,000 |
Milestone payments earned |  | $ 10,000,000
Maximum amount eligible for development and regulatory milestones |  | 90,000,000
Maximum amount eligible for commercial milestones under collaborations agreement |  | 83,000,000
Remaining performance obligation |  | 25,600,000
Net contract liability |  | $ 2,600,000
Collaborative arrangement with Takeda | Global |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 20.00%
Collaborative arrangement with Takeda | Japan |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  | 100.00%
Collaboration period to achieve specified levels of commercial performance |  | 2 years
Collaborative arrangement with Takeda | Initial |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Royalty tier |  | $ 300,000,000.0
Collaborative arrangement with Takeda | Minimum | Initial |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 15.00%
Collaborative arrangement with Takeda | Minimum | Final tier |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 20.00%
Collaborative arrangement with Takeda | Maximum | Initial |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 24.00%
Collaborative arrangement with Takeda | Maximum | Final tier |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Percent of royalty on net sale |  | 30.00%

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