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Organization and Summary of Significant Accounting Policies (Narrative) (Details)
12 Months Ended 35 Months Ended
Dec. 30, 2017
USD ($)
Dec. 28, 2018
USD ($)
segment
product
Dec. 29, 2017
USD ($)
Dec. 30, 2016
USD ($)
Dec. 28, 2018
USD ($)
Organization And Summary Of Significant Policies [Line Items]          
Number of products that entered in the commercial marketplace | product   4      
Number of operating segments | segment   1      
Increase in net cash provided by investing activities   $ (297,850,000) $ 36,795,000 $ (214,548,000)  
Accumulated deficit $ 1,570,433,000 $ 880,363,000 1,829,172,000   $ 880,363,000
Number of reportable segments | segment   1      
Impairment charge on goodwill   $ 0 0 0  
Percent discount for prompt payment   2.00%      
Discount expected to be earned   100.00%      
Inventory expensed as research and development, not capitalized as inventory   $ 0     0
Collaborative Arrangement with Ipsen          
Organization And Summary Of Significant Policies [Line Items]          
Milestone payments earned   $ 140,000,000     $ 275,000,000
Collaborative Arrangement with Ipsen | Collaborative Arrangement with GlaxoSmithKline          
Organization And Summary Of Significant Policies [Line Items]          
Percent of royalty on net sale   3.00%      
ASU 2016-18          
Organization And Summary Of Significant Policies [Line Items]          
Increase in net cash provided by investing activities     $ 1,000,000 $ 1,500,000  
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606          
Organization And Summary Of Significant Policies [Line Items]          
Accumulated deficit (258,505,000)        
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 | Collaborative Arrangement with Ipsen | EMA Filing Acceptance - HCC          
Organization And Summary Of Significant Policies [Line Items]          
Milestone payments earned 10,000,000        
ASU 2016-02 | Restatement          
Organization And Summary Of Significant Policies [Line Items]          
Accumulated deficit $ (234,000)        
Commercial Presence in Markets Worldwide          
Organization And Summary Of Significant Policies [Line Items]          
Number of products that entered in the commercial marketplace | product   3      
Products Derived from Cabozantinib          
Organization And Summary Of Significant Policies [Line Items]          
Number of products that entered in the commercial marketplace | product   2