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Organization and Summary of Significant Accounting Policies (Impact of Adoption of Topic 606 and Topic 842 on the Consolidated Statements of Operations) (Details) - USD ($)
$ / shares in Units, $ in Thousands
 3 Months Ended 12 Months Ended
Dec. 28, 2018
Sep. 28, 2018
Jun. 29, 2018
Mar. 30, 2018
Dec. 29, 2017
Sep. 30, 2017
Jun. 30, 2017
Mar. 31, 2017
Dec. 28, 2018
Dec. 29, 2017
Dec. 30, 2016
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Total revenues $ 228,602 $ 225,397 $ 186,108 $ 213,719 $ 120,072 $ 152,510 $ 99,008 $ 80,887 $ 853,826 $ 452,477 $ 191,454
Selling, general and administrative                 206,366 159,362 116,145
Total operating expenses                 414,971 286,567 219,578
Interest expense                 0 (8,679) (33,060)
Total other income (expense), net                 13,237 (7,333) (42,098)
Income before income taxes                 452,092 158,577 (70,222)
Income tax benefit (provision)                 237,978 (4,350) 0
Net income (loss) $ 360,089 $ 126,630 $ 87,494 $ 115,857 $ 38,489 $ 81,382 $ 17,656 $ 16,700 $ 690,070 $ 154,227 $ (70,222)
Net income per share, basic (in dollars per share) $ 1.20 $ 0.42 $ 0.29 $ 0.39 $ 0.13 $ 0.28 $ 0.06 $ 0.06 $ 2.32 $ 0.52 $ (0.28)
Net income per share, diluted (in dollars per share) $ 1.15 $ 0.41 $ 0.28 $ 0.37 $ 0.12 $ 0.26 $ 0.06 $ 0.05 $ 2.21 $ 0.49 $ (0.28)
Collaboration revenue                      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Total revenues                 $ 234,547 $ 103,469 $ 56,079
Calculated under Revenue Guidance in Effect before Topic 606 [Member] | Collaboration revenue                      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Total revenues                 270,429    
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606                      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Total revenues                 (35,882)    
Income before income taxes                 (35,882)    
Income tax benefit (provision)                 (48,325)    
Net income (loss)                 $ (84,207)    
Net income per share, basic (in dollars per share)                 $ (0.28)    
Net income per share, diluted (in dollars per share)                 $ (0.27)    
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 | Collaboration revenue                      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Total revenues                 $ (35,882)    
ASU 2016-02                      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Selling, general and administrative                 1,204    
Total operating expenses                 1,204    
Interest expense                 (631)    
Total other income (expense), net                 631    
Income before income taxes                 (573)    
Income tax benefit (provision)                 73    
Net income (loss)                 $ (500)    
Net income per share, basic (in dollars per share)                 $ 0.00    
Net income per share, diluted (in dollars per share)                 $ 0.00    
Calculated Under Guidance In Effect Before Topic 606 And Topic 842 [Member]                      
Revenue, Initial Application Period Cumulative Effect Transition [Line Items]                      
Total revenues                 $ 889,708    
Selling, general and administrative                 205,162    
Total operating expenses                 413,767    
Interest expense                 631    
Total other income (expense), net                 12,606    
Income before income taxes                 488,547    
Income tax benefit (provision)                 286,230    
Net income (loss)                 $ 774,777    
Net income per share, basic (in dollars per share)                 $ 2.60    
Net income per share, diluted (in dollars per share)                 $ 2.48