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Collaboration Agreements (Ipsen Collaboration, Narrative) (Details) - Collaborative arrangement with Ipsen
1 Months Ended 6 Months Ended 12 Months Ended 35 Months Ended
Dec. 30, 2017
USD ($)
Feb. 29, 2016
USD ($)
Jun. 29, 2018
USD ($)
Dec. 28, 2018
USD ($)
Dec. 28, 2018
CAD ($)
Dec. 28, 2018
USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Collaboration period to achieve specified levels of commercial performance       10 years 10 years  
Upfront payment(s)   $ 210,000,000        
Milestone payments earned       $ 140,000,000   $ 275,000,000
Eligible payment from collaboration for development and regulatory milestone achievement under collaborations agreement   84,000,000        
Maximum amount eligible for commercial milestones under collaborations agreement   $ 519,500,000        
Remaining performance obligation       $ 48,000,000   48,000,000
Research and development arrangement performed for others, reimbursement for costs incurred, percent       35.00% 35.00%  
Net contract liability       $ 13,300,000   $ 13,300,000
Collaborative Arrangement with GlaxoSmithKline            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Percent of royalty on net sale       3.00% 3.00%  
Final tier            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Royalty tier     $ 150,000,000   $ 30,000,000.0  
Initial            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Percent of royalty on net sale     2.00%      
Second            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Percent of royalty on net sale     12.00%      
Minimum | Final tier            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Percent of royalty on net sale       22.00% 22.00%  
Maximum | Final tier            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Percent of royalty on net sale       26.00% 26.00%  
EMA Filing Acceptance - HCC | Adjustments Due to the Adoption of Topic 606 | ASU 2014-09            
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]            
Milestone payments earned $ 10,000,000