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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 28, 2018
Dec. 29, 2017
Dec. 30, 2016
Cash flows from operating activities:      
Net income (loss) $ 690,070 $ 154,227 $ (70,222)
Adjustments to reconcile net loss to net cash provided by (used in) operating activities:      
Depreciation and amortization 4,915 1,187 1,002
Stock-based compensation 40,626 23,938 22,912
401(k) matching contributions made in common stock 3,696 1,640 1,036
Right-of-Use Asset, Amortization 2,854 0 0
Deferred taxes (244,111) 0 0
Loss on extinguishment of debt 0 6,239 13,901
Amortization of debt discounts and debt issuance costs 0 182 8,432
Interest paid in kind 0 (11,825) 8,008
Gain on other equity investments (209) (2,980) (2,494)
Other (2,358) (51) 562
Changes in operating assets and liabilities:      
Trade and other receivables (85,471) (43,299) (38,680)
Other receivables (4,410) 2,460 3,362
Inventory, net (3,181) (3,319) (722)
Prepaid expenses and other current assets (3,029) (3,268) (1,610)
Other long-term assets (1,086) 430 1,077
Accounts payable 856 3,010 164
Accrued compensation and benefits 11,069 739 16,705
Accrued clinical trial liabilities (1,618) 5,718 (3,940)
Rebates and fees due customers 7,389 4,145 3,866
Accrued collaboration liabilities (1,555) 6,928 (10,938)
Deferred revenue 271 13,745 256,759
Long-term portion of lease liabilities (1,225) 14,938 0
Other current and long-term liabilities 2,227 (9,173) 1,224
Net cash used in operating activities 415,720 165,611 210,404
Cash flows from investing activities:      
Purchases of property and equipment (33,297) (21,143) (1,703)
Proceeds from sale of property and equipment 308 164 97
Purchases of investments (557,832) (319,090) (369,187)
Proceeds from maturities of investments 280,826 336,590 151,485
Proceeds from sale of investments 11,936 37,294 2,266
Proceeds from other equity investments 209 2,980 2,494
Net cash (used in) provided by investing activities (297,850) 36,795 (214,548)
Cash flows from financing activities:      
Proceeds from exercise of stock options 12,076 17,555 25,327
Proceeds from employee stock purchase plan 5,202 4,868 2,187
Taxes paid related to net share settlement of equity awards (7,574) (6,563) (4,108)
Principal payments on financing lease obligation (13) 0 0
Principal repayments of debt 0 (185,788) (575)
Payments on conversion of convertible notes 0 0 (7,135)
Net cash provided by financing activities 9,691 (169,928) 15,696
Net increase in cash, cash equivalents and restricted cash 127,561 32,478 11,552
Cash, cash equivalents and restricted cash at beginning of period 188,314 155,836 144,284
Cash, cash equivalents and restricted cash at end of period 315,875 188,314 155,836
Supplemental cash flow disclosure:      
Cash paid for interest 0 20,460 21,044
Cash paid for taxes 10,677 538 190
Non-cash investing and financing activity:      
Property and equipment deemed to have been acquired in build-to-suit lease 0 14,530 0
Right-of-use assets obtained in exchange for lease obligations [1] 17,180 0 0
Unpaid liabilities incurred to acquire Property and equipment 802 524 0
Issuance of common stock in settlement of convertible notes $ 0 $ 0 $ 286,925
[1] Amounts for the year ended December 31, 2018 include the transition adjustment for the adoption of Topic 842.