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Collaboration Agreements - Royalty Revenues under the Collaboration Agreement with Genentech (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 29, 2019 | Mar. 30, 2018
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Royalty revenues on ex-U.S. sales | $ 215,487 | $ 213,719
COTELLIC | Collaborative Arrangement with Genentech |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |
Royalty revenues on ex-U.S. sales | 1,490 | 1,349
Profits and losses on U.S. commercialization | $ 1,055 | $ 1,373

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