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Revenues - Revenues by Disaggregated Category (Details) - USD ($) $ in Thousands | 3 Months Ended
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Mar. 29, 2019 | Mar. 30, 2018
Disaggregation of Revenue [Line Items] |  |
Total revenues | $ 215,487 | $ 213,719
Collaborative Arrangement with Ipsen |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | $ 21,868 | 53,809
GSK | Collaborative Arrangement with Ipsen |  |
Disaggregation of Revenue [Line Items] |  |
Percent of royalty on net sale | 3.00% |
Net product revenues |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | $ 179,581 | 134,272
Gross product revenues |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | 223,750 | 159,436
Discounts and allowances |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | 44,169 | 25,164
Total collaboration revenues |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | 35,906 | 79,447
License revenues |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | 24,509 | 69,030
Research and development services revenues |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | 11,928 | 10,099
Other collaboration revenues |  |
Disaggregation of Revenue [Line Items] |  |
Total revenues | $ (531) | $ 318

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