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Subsequent Event (Details)
 12 Months Ended
Apr. 29, 2019
USD ($)
Apr. 15, 2019
USD ($)
ft²
Dec. 28, 2018
USD ($)
Apr. 01, 2019
USD ($)
ft²
Collaborative Arrangement with Takeda        
Subsequent Event [Line Items]        
Milestone payments earned     $ 10,000,000  
Subsequent Event | Collaborative Arrangement with Takeda        
Subsequent Event [Line Items]        
Limit on reimbursement per year $ 1,000,000      
Increase in maximum amount eligible for development and regulatory milestones 12,000,000      
Maximum amount eligible for development and regulatory milestones 102,000,000      
Milestone payments earned 16,000,000      
Increase in maximum amount eligible for commercial milestones under collaborations agreement 3,000,000      
Maximum amount eligible for commercial milestones under collaborations agreement $ 86,000,000      
Subsequent Event | Corporate Headquarters, Alameda, California        
Subsequent Event [Line Items]        
Operating lease, expansion (in square feet) | ft²       37,544
Operating lease, surrendered (in square feet) | ft²       2,703
Tenant improvement allowance       $ 1,700,000
Area of lease property (in square feet) | ft²   169,606    
Aggregate contractual base rent   $ 34,600,000    
Subsequent Event | Corporate Headquarters, Alameda, California | Minimum        
Subsequent Event [Line Items]        
Monthly base rent   224,505    
Operating lease, not yet commenced, monthly base rent   71,334    
Subsequent Event | Corporate Headquarters, Alameda, California | Maximum        
Subsequent Event [Line Items]        
Monthly base rent   283,933    
Operating lease, not yet commenced, monthly base rent   $ 90,481