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Condensed Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 29, 2019
Mar. 30, 2018
Statement of Cash Flows [Abstract]    
Net income $ 75,775 $ 115,857
Adjustments to reconcile net income (loss) to net cash provided by operating activities:    
Depreciation and amortization 1,962 371
Stock-based compensation expense 12,529 9,305
401(k) matching contributions made in common stock 2,469 1,880
Amortization and other right-of-use assets (7,730) 0
Gain on other equity investments 0 (209)
Other (1,415) (158)
Changes in assets and liabilities:    
Trade receivables, net 55,101 (10,819)
Other receivables 8,741 64
Inventory, net (305) (906)
Unbilled collaboration revenue (7,753) (38,014)
Prepaid expenses and other current assets 871 1,900
Other long-term assets (4,854) (346)
Accounts payable (1,294) (183)
Accrued compensation and benefits (9,592) (317)
Accrued clinical trial liabilities 4,824 (4,498)
Rebates and fees due customers 4,754 4,424
Accrued collaboration liabilities 137 (1,000)
Current and long-term deferred revenue (1,313) (2,652)
Long-term portion of lease liabilities 7,517 (35)
Other current and long-term liabilities 21,169 (2,856)
Net cash provided by operating activities 161,593 71,808
Cash flows from investing activities:    
Purchases of Property and equipment and other, net (2,307) (2,947)
Purchases of investments (239,869) (116,537)
Proceeds from maturities of investments 129,820 87,504
Proceeds from sale of investments 4,699 6,238
Proceeds from other equity investments 0 209
Net cash used in investing activities (107,657) (25,533)
Cash flows from financing activities:    
Proceeds from exercise of stock options 6,817 1,875
Taxes paid related to net share settlement of equity awards (1,580) (2,129)
Principal payments on financing lease obligation (11) 0
Net cash provided by (used in) financing activities 5,226 (254)
Net increase in cash, cash equivalents and restricted cash 59,162 46,021
Cash, cash equivalents and restricted cash at beginning of period 315,875 188,314
Cash, cash equivalents and restricted cash at end of period 375,037 234,335
Supplemental cash flow disclosure    
Right-of-use assets obtained in exchange for lease obligations [1] 8,170 17,180
Unpaid liabilities incurred to acquire Property and equipment $ 141 $ 6,608
[1] Amounts for the three months ended March 31, 2019 include receipt of a tenant inventive payment. Amounts for the three months ended March 31, 2018 include the transition adjustment for the adoption of Accounting Standards Codification (ASC) Topic 842, Leases.