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Condensed Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 27, 2019 | Sep. 28, 2018
Statement of Cash Flows [Abstract] |  |  |
Net income |  | $ 252,269 | $ 329,981
Adjustments to reconcile net income to net cash provided by operating activities: |  |  |
Depreciation and amortization |  | 6,088 | 2,876
Stock-based compensation |  | 40,747 | 28,330
401(k) matching contributions made in common stock |  | 4,079 | 3,232
Amortization and other changes in right-of-use assets |  | (6,367) | 2,732
Deferred income taxes |  | 56,339 | 0
Gain on other equity investments |  | (730) | (209)
Accretion of investments, net and other |  | (3,970) | (1,423)
Changes in operating assets and liabilities: |  |  |
Trade receivables, net |  | (7,017) | (12,707)
Other receivables |  | 2,469 | (2,938)
Inventory, net |  | (3,528) | (3,776)
Current portion of unbilled collaboration revenue |  | (2,640) | (32,673)
Prepaid expenses and other current assets |  | 527 | (3,529)
Other long-term assets |  | (6,294) | (542)
Accounts payable |  | (2,708) | (1,248)
Accrued compensation and benefits |  | (429) | 6,210
Accrued clinical trial liabilities |  | 12,099 | (891)
Rebates and fees due customers |  | 1,828 | 4,124
Accrued collaboration liability |  | 554 | (577)
Current and long-term deferred revenue |  | 3,592 | (1,548)
Long-term portion of lease liabilities |  | 6,087 | (974)
Other current and long-term liabilities |  | 15,940 | (3,321)
Net cash provided by operating activities |  | 368,935 | 311,129
Cash flows from investing activities: |  |  |
Purchases of property and equipment |  | (5,575) | (30,403)
Proceeds from sale of property and equipment |  | 0 | 308
Purchases of investments |  | (887,698) | (368,304)
Proceeds from maturities of investments |  | 422,419 | 231,204
Proceeds from sale of investments |  | 13,078 | 11,935
Proceeds from other equity investments |  | 730 | 209
Net cash used in investing activities |  | (457,046) | (155,051)
Cash flows from financing activities: |  |  |
Proceeds from exercise of stock options |  | 14,811 | 10,390
Proceeds from employee stock purchase plan |  | 4,145 | 3,650
Taxes paid related to net share settlement of equity awards |  | (3,369) | (3,205)
Principal payments on financing lease obligation |  | (34) | 0
Net cash provided by financing activities |  | 15,553 | 10,835
Net (decrease) increase in cash, cash equivalents and restricted cash |  | (72,558) | 166,913
Cash, cash equivalents and restricted cash at beginning of period |  | 315,875 | 188,314
Cash, cash equivalents and restricted cash at end of period |  | 243,317 | 355,227
Supplemental cash flow disclosure: |  |  |
Right-of-use assets obtained in exchange for lease obligations | [1] | 12,944 | 17,180
Unpaid liabilities incurred to acquire Property and equipment |  | 159 | 1,281
Unpaid liabilities incurred to acquire investments |  | $ 8,961 | $ 0
[1] | Amounts for the nine months ended September 30, 2019 include receipt of a tenant incentive payment and an amendment to our existing lease for office and research space. Amounts for the nine months ended September 30, 2018 include the transition adjustment for the adoption of Topic 842.

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- Definition Amount of noncash expense (reversal of expense) for pension and other postretirement benefits. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3602-108585 + Details
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- Definition Amount of cash inflow from maturity, prepayment and call of investment in debt security measured at fair value with change in fair value recognized in other comprehensive income (available-for-sale). + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118954083&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3151-108585 Reference 3: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow associated with the sale and maturity (principal being due) of other investments, prepayment and call (request of early payment) of other investments not otherwise defined in the taxonomy. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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- Definition The cash inflow from the sale of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3179-108585 + Details
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