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Collaboration Agreements (Tables)
9 Months Ended
Sep. 27, 2019
Organization, Consolidation and Presentation of Financial Statements [Abstract]  
Schedule of Collaborative Revenues Under Collaboration Agreement
Collaboration revenues under the collaboration agreement with Takeda were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2019
 
2018
 
2019
 
2018
Takeda collaboration revenues
$
1,187

 
$
1,940

 
$
14,245

 
$
6,843


Collaboration revenues under the collaboration agreement with Ipsen were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2019
 
2018
 
2019
 
2018
Ipsen collaboration revenues
$
76,016

 
$
57,186

 
$
120,133

 
$
145,038


Profits on U.S. commercialization and Royalty revenues on ex-U.S. sales were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2019
 
2018
 
2019
 
2018
Profits on U.S. commercialization
$
1,102

 
$
1,935

 
$
3,507

 
$
6,004

Royalty revenues on ex-U.S. sales
$
1,614

 
$
1,390

 
$
4,426

 
$
4,285


Collaboration revenues under the collaboration agreement with Daiichi Sankyo were as follows (in thousands):
 
Nine Months Ended September 30,
 
2019
 
2018
Daiichi Sankyo collaboration revenues
$
20,130

 
$
20,000


Such royalties accruing to GSK were as follows (in thousands):
 
Three Months Ended September 30,
 
Nine Months Ended September 30,
 
2019
 
2018
 
2019
 
2018
Royalties accruing to GSK
$
7,964

 
$
6,268

 
$
23,079

 
$
17,021