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Condensed Consolidated Statements of Income - USD ($)
shares in Thousands, $ in Thousands
 3 Months Ended 9 Months Ended
Sep. 27, 2019
Sep. 28, 2018
Sep. 27, 2019
Sep. 28, 2018
Total revenues $ 271,703 $ 225,397 $ 727,465 $ 625,224
Operating expenses:        
Cost of goods sold 7,537 7,360 22,577 18,996
Research and development 97,295 44,741 242,516 124,986
Selling, general and administrative 51,265 48,120 170,218 153,989
Total operating expenses 156,097 100,221 435,311 297,971
Income from operations 115,606 125,176 292,154 327,253
Other income (expense), net:        
Interest income 7,191 3,507 20,253 8,099
Other, net (140) 271 688 368
Total other income (expense), net: 7,051 3,778 20,941 8,467
Income before income taxes 122,657 128,954 313,095 335,720
Provision for income taxes (25,205) (2,324) (60,826) (5,739)
Net income $ 97,452 $ 126,630 $ 252,269 $ 329,981
Net income per share, basic (in dollars per share) $ 0.32 $ 0.42 $ 0.84 $ 1.11
Net income per share, diluted (in dollars per share) $ 0.31 $ 0.41 $ 0.80 $ 1.05
Shares used in computing net income per share, basic (in shares) 303,268 298,416 301,999 297,700
Shares used in computing net income per share, diluted (in shares) 315,453 312,346 315,046 313,200
Net product revenues        
Total revenues $ 191,768 $ 162,946 $ 565,024 $ 443,054
Collaboration revenue        
Total revenues $ 79,935 $ 62,451 $ 162,441 $ 182,170