<SEC-DOCUMENT>0000939767-19-000006.txt : 20190104
<SEC-HEADER>0000939767-19-000006.hdr.sgml : 20190104
<ACCEPTANCE-DATETIME>20190104205035
ACCESSION NUMBER:		0000939767-19-000006
CONFORMED SUBMISSION TYPE:	4
PUBLIC DOCUMENT COUNT:		1
CONFORMED PERIOD OF REPORT:	20190102
FILED AS OF DATE:		20190104
DATE AS OF CHANGE:		20190104

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			MORRISSEY MICHAEL
		CENTRAL INDEX KEY:			0001202096

	FILING VALUES:
		FORM TYPE:		4
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		19512017

	MAIL ADDRESS:	
		STREET 1:		C/O EXELIXIS INC
		STREET 2:		170 HARBOR WAY
		CITY:			SAN FRANCISCO
		STATE:			CA
		ZIP:			94083

	FORMER NAME:	
		FORMER CONFORMED NAME:	MORRISSEY MICHAEL M
		DATE OF NAME CHANGE:	20030512

	FORMER NAME:	
		FORMER CONFORMED NAME:	MORRISSEY MICHAEL R
		DATE OF NAME CHANGE:	20021029

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1228

	BUSINESS ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106
</SEC-HEADER>
<DOCUMENT>
<TYPE>4
<SEQUENCE>1
<FILENAME>wf-form4_154665301832587.xml
<DESCRIPTION>FORM 4
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        <issuerName>EXELIXIS, INC.</issuerName>
        <issuerTradingSymbol>EXEL</issuerTradingSymbol>
    </issuer>

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            <rptOwnerName>MORRISSEY MICHAEL</rptOwnerName>
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            <rptOwnerStreet1>C/O EXELIXIS, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>1851 HARBOR BAY PARKWAY</rptOwnerStreet2>
            <rptOwnerCity>ALAMEDA</rptOwnerCity>
            <rptOwnerState>CA</rptOwnerState>
            <rptOwnerZipCode>94502</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
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            <isOfficer>1</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
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            <officerTitle>President and CEO</officerTitle>
            <otherText></otherText>
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                <directOrIndirectOwnership>
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                <natureOfOwnership>
                    <value>By 401(k)</value>
                </natureOfOwnership>
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        </nonDerivativeHolding>
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        <derivativeTransaction>
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            <transactionDate>
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                <equitySwapInvolved>0</equitySwapInvolved>
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                <transactionPricePerShare>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2013-09-21</value>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2019-09-20</value>
            </expirationDate>
            <underlyingSecurity>
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                </underlyingSecurityShares>
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                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>3571</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
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                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
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            <exerciseDate>
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                <underlyingSecurityShares>
                    <value>3571.0</value>
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                <sharesOwnedFollowingTransaction>
                    <value>392383</value>
                </sharesOwnedFollowingTransaction>
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                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
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        </derivativeTransaction>
        <derivativeTransaction>
            <securityTitle>
                <value>Common Stock</value>
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            <conversionOrExercisePrice>
                <value>5.56</value>
            </conversionOrExercisePrice>
            <transactionDate>
                <value>2019-01-04</value>
            </transactionDate>
            <transactionCoding>
                <transactionFormType>4</transactionFormType>
                <transactionCode>M</transactionCode>
                <equitySwapInvolved>0</equitySwapInvolved>
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            <transactionAmounts>
                <transactionShares>
                    <value>30383</value>
                </transactionShares>
                <transactionPricePerShare>
                    <value>0</value>
                </transactionPricePerShare>
                <transactionAcquiredDisposedCode>
                    <value>D</value>
                </transactionAcquiredDisposedCode>
            </transactionAmounts>
            <exerciseDate>
                <value>2013-09-21</value>
                <footnoteId id="F7"/>
            </exerciseDate>
            <expirationDate>
                <value>2019-09-20</value>
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                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>30383.0</value>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>362000</value>
                </sharesOwnedFollowingTransaction>
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            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>D</value>
                </directOrIndirectOwnership>
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    <footnotes>
        <footnote id="F1">On November 27, 2018, the reporting person gifted 17,647 shares to Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Trust dated July 21, 1994, as amended.</footnote>
        <footnote id="F2">Includes 90,000 shares of Exelixis, Inc. common stock that will be issued to the Reporting Person upon vesting of restricted stock units.</footnote>
        <footnote id="F3">Shares held by Michael M. Morrissey and Meghan D. Morrissey, Trustees of the Morrissey Family Living Trust dated July 21, 1994, as amended.</footnote>
        <footnote id="F4">The sales reported on this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the Reporting Person on November 29, 2018.</footnote>
        <footnote id="F5">Represents the weighted average sales price. The shares were sold in multiple transactions at prices ranging from $20.00 to $20.38. Reporting Person undertakes to provide Exelixis, Inc., any security holder of Exelixis, Inc., or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in footnote 5 to this Form 4.</footnote>
        <footnote id="F6">Represents shares of Exelixis, Inc. common stock under the Exelixis, Inc. 401(k) Plan, pursuant to a plan statement dated as of January 2, 2019.</footnote>
        <footnote id="F7">The option, representing the right to purchase a total of 402,000 shares of Exelixis, Inc. common stock, became fully exercisable on September 21, 2016.</footnote>
    </footnotes>

    <remarks></remarks>

    <ownerSignature>
        <signatureName>/s/ Jennifer Drimmer Rokovich, Attorney in Fact</signatureName>
        <signatureDate>2019-01-04</signatureDate>
    </ownerSignature>
</ownershipDocument>
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</SEC-DOCUMENT>
