<SEC-DOCUMENT>0000939767-19-000108.txt : 20190501
<SEC-HEADER>0000939767-19-000108.hdr.sgml : 20190501
<ACCEPTANCE-DATETIME>20190501160823
ACCESSION NUMBER:		0000939767-19-000108
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20190501
ITEM INFORMATION:		Results of Operations and Financial Condition
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20190501
DATE AS OF CHANGE:		20190501

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			EXELIXIS, INC.
		CENTRAL INDEX KEY:			0000939767
		STANDARD INDUSTRIAL CLASSIFICATION:	SERVICES-COMMERCIAL PHYSICAL & BIOLOGICAL RESEARCH [8731]
		IRS NUMBER:				043257395
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			0103

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	000-30235
		FILM NUMBER:		19787518

	BUSINESS ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502
		BUSINESS PHONE:		6508377000

	MAIL ADDRESS:	
		STREET 1:		1851 HARBOR BAY PARKWAY
		CITY:			ALAMEDA
		STATE:			CA
		ZIP:			94502

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS INC
		DATE OF NAME CHANGE:	20000207

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	EXELIXIS PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20000106
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>exel8-kq12019earningsrelea.htm
<DESCRIPTION>8-K
<TEXT>
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<div><a name="s2CFD84865A485C6FBFD62DFC93AA74BC"></a></div><div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></div><div><br></div><div style="line-height:120%;padding-top:4px;text-align:center;font-size:16pt;"><font style="font-family:Calibri,sans-serif;font-size:16pt;font-weight:bold;">UNITED STATES</font></div><div style="line-height:120%;text-align:center;font-size:16pt;"><font style="font-family:Calibri,sans-serif;font-size:16pt;font-weight:bold;">SECURITIES AND EXCHANGE COMMISSION</font></div><div style="line-height:120%;text-align:center;font-size:12pt;"><font style="font-family:Calibri,sans-serif;font-size:12pt;font-weight:bold;">Washington, D.C. 20549</font><font style="font-family:Calibri,sans-serif;font-size:9pt;">&#160;</font></div><div style="line-height:120%;text-align:center;font-size:16pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;margin-left:auto;margin-right:auto;width:300px;border-collapse:collapse;text-align:left;"><tr><td colspan="1"></td></tr><tr><td style="width:300px;"></td></tr><tr><td style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="padding-top:2px;text-align:center;font-size:16pt;"><font style="font-family:Calibri,sans-serif;font-size:16pt;font-weight:bold;">FORM 8-K</font></div></td></tr></table></div></div><div style="line-height:120%;padding-top:6px;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">CURRENT REPORT </font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">PURSUANT TO SECTION 13 OR 15(d) OF THE </font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">SECURITIES EXCHANGE ACT OF 1934 </font></div><div style="line-height:120%;padding-top:12px;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">Date of Report (Date of earliest event reported): </font><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">May&#160;1, 2019</font></div><div style="line-height:120%;text-align:center;font-size:16pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;margin-left:auto;margin-right:auto;width:300px;border-collapse:collapse;text-align:left;"><tr><td colspan="1"></td></tr><tr><td style="width:300px;"></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;"><img src="exellogo18q3a02.jpg" alt="exellogo18q3a02.jpg" style="height:64px;width:190px;"></div></td></tr><tr><td style="vertical-align:top;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-top:2px;text-align:center;font-size:16pt;"><font style="font-family:Calibri,sans-serif;font-size:16pt;font-weight:bold;">EXELIXIS, INC.</font></div><div style="text-align:center;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;">(Exact name of registrant as specified in its charter)</font></div></td></tr></table></div></div><div style="line-height:100%;text-align:center;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;margin-left:auto;margin-right:auto;width:100%;border-collapse:collapse;text-align:left;"><tr><td colspan="3"></td></tr><tr><td style="width:34%;"></td><td style="width:33%;"></td><td style="width:33%;"></td></tr><tr><td style="vertical-align:top;padding-left:2px;padding-top:2px;padding-bottom:1px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">Delaware</font></div></td><td style="vertical-align:top;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">000-30235</font></div></td><td style="vertical-align:top;padding-left:2px;padding-top:2px;padding-bottom:1px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">04-3257395</font></div></td></tr><tr><td style="vertical-align:top;padding-left:2px;padding-top:2px;padding-bottom:1px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;text-indent:2px;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;">(State or Other Jurisdiction  <br>of Incorporation)</font></div></td><td style="vertical-align:top;padding-left:2px;padding-top:2px;padding-bottom:1px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;text-indent:2px;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;">(Commission  <br>File Number)</font></div></td><td style="vertical-align:top;padding-left:2px;padding-top:2px;padding-bottom:1px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;text-indent:2px;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;">(IRS Employer  <br>Identification No.)</font></div></td></tr></table></div></div><div style="line-height:120%;text-align:center;font-size:12pt;"><font style="font-family:Calibri,sans-serif;font-size:12pt;"><br></font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">1851 Harbor Bay Parkway</font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">Alameda, California 94502</font></div><div style="line-height:120%;text-align:center;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;">(Address of principal executive offices) (Zip Code)</font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;"><br></font></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">(650) 837-7000</font></div><div style="line-height:120%;text-align:center;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;">(Registrant&#8217;s telephone number, including area code) </font></div><div style="line-height:120%;padding-top:12px;text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions (see General Instruction A.2. below): </font></div><table cellpadding="0" cellspacing="0" style="padding-top:12px;font-family:Times New Roman; font-size:10pt;"><tr><td style="width:33px;"></td><td></td></tr><tr><td style="vertical-align:top"><div style="line-height:120%;font-size:10pt;padding-left:1px;"><font style="font-family:Wingdings;font-size:10pt;">&#168;</font></div></td><td style="vertical-align:top;"><div style="line-height:120%;text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425) </font></div></td></tr></table><table cellpadding="0" cellspacing="0" style="padding-top:12px;font-family:Times New Roman; font-size:10pt;"><tr><td style="width:33px;"></td><td></td></tr><tr><td style="vertical-align:top"><div style="line-height:120%;font-size:10pt;padding-left:1px;"><font style="font-family:Wingdings;font-size:10pt;">&#168;</font></div></td><td style="vertical-align:top;"><div style="line-height:120%;text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12) </font></div></td></tr></table><table cellpadding="0" cellspacing="0" style="padding-top:12px;font-family:Times New Roman; font-size:10pt;"><tr><td style="width:33px;"></td><td></td></tr><tr><td style="vertical-align:top"><div style="line-height:120%;font-size:10pt;padding-left:1px;"><font style="font-family:Wingdings;font-size:10pt;">&#168;</font></div></td><td style="vertical-align:top;"><div style="line-height:120%;text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b)) </font></div></td></tr></table><table cellpadding="0" cellspacing="0" style="padding-top:12px;font-family:Times New Roman; font-size:10pt;"><tr><td style="width:33px;"></td><td></td></tr><tr><td style="vertical-align:top"><div style="line-height:120%;font-size:10pt;padding-left:1px;"><font style="font-family:Wingdings;font-size:10pt;">&#168;</font></div></td><td style="vertical-align:top;"><div style="line-height:120%;text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c)) </font></div></td></tr></table><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div><div style="line-height:120%;text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter). Emerging growth company</font><font style="font-family:inherit;font-size:10pt;">&#32;</font><font style="font-family:Wingdings;font-size:10pt;">&#168;</font></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div><div style="line-height:120%;text-align:justify;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section 13(a) of the Exchange Act.</font><font style="font-family:inherit;font-size:10pt;">&#32;</font><font style="font-family:Wingdings;font-size:10pt;">&#168;</font></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div><div><br></div><div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></div><hr style="page-break-after:always"><div><a name="s1393011D7261537087DEBF2B21FBB7AA"></a></div><div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></div><div><br></div><div style="line-height:120%;-sec-extract:summary;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">Item 2.02.  Results of Operations and Financial Condition.</font></div><div style="line-height:120%;padding-top:12px;text-align:left;text-indent:48px;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">On </font><font style="font-family:Calibri,sans-serif;font-size:10pt;">May&#160;1, 2019</font><font style="font-family:Calibri,sans-serif;font-size:10pt;">, Exelixis, Inc. (&#8220;Exelixis&#8221;) issued a press release announcing its financial results for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:10pt;">March&#160;29, 2019</font><font style="font-family:Calibri,sans-serif;font-size:10pt;">, and providing a corporate update. A copy of such press release is furnished herewith as Exhibit 99.1 and is incorporated herein by reference. </font></div><div style="line-height:120%;padding-top:12px;text-align:left;text-indent:48px;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">The information in this report, including the exhibit hereto, shall not be deemed &#8220;filed&#8221; for purposes of Section&#160;18 of the Securities Exchange Act of 1934, as amended, or otherwise subject to the liabilities of that section or Sections 11 and 12(a)(2) of the Securities Act of 1933, as amended. The information contained in this report and in the accompanying exhibit shall not be incorporated by reference into any filing with the U.S. Securities and Exchange Commission made by Exelixis, whether made before or after the date hereof, regardless of any general incorporation language in such filing. </font></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;"><br></font></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">Item 9.01.  Financial Statements and Exhibits.</font></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;"><br></font></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">(d) &#160;&#160;&#160;&#160;Exhibits.</font></div><div style="line-height:120%;text-align:left;padding-left:0px;text-indent:0px;font-size:10pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:59.523809523809526%;border-collapse:collapse;text-align:left;"><tr><td colspan="3"></td></tr><tr><td style="width:23%;"></td><td style="width:2%;"></td><td style="width:75%;"></td></tr><tr><td style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;font-weight:bold;">Exhibit Number</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;font-weight:bold;">Exhibit Description</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">99.1</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="font-size:10pt;"><a style="text-decoration:underline;color:#0000FF;-sec-extract:exhibit;" href="exel20190331exhibit991.htm"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Press Release issued May 1, 2019.</font></a></div></td></tr></table></div></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;"><br></font></div><div><br></div><div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></div><hr style="page-break-after:always"><div><a name="s5714DE42C33A587A95F578E3A2B28794"></a></div><div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></div><div><br></div><div style="line-height:120%;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;font-weight:bold;">SIGNATURES </font></div><div style="line-height:120%;padding-top:12px;text-align:left;text-indent:48px;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized. </font></div><div style="line-height:120%;text-align:right;font-size:10pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;text-align:-moz-right;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:71.42857142857143%;border-collapse:collapse;text-align:left;margin-left:auto;margin-right:0;"><tr><td colspan="4"></td></tr><tr><td style="width:28%;"></td><td style="width:8%;"></td><td style="width:8%;"></td><td style="width:56%;"></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">E</font><font style="font-family:Calibri,sans-serif;font-size:8pt;">XELIXIS, </font><font style="font-family:Calibri,sans-serif;font-size:10pt;">I</font><font style="font-family:Calibri,sans-serif;font-size:8pt;">NC.</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:18px;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:18px;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:18px;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;height:18px;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td></tr><tr><td style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">May&#160;1, 2019</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="padding-bottom:1px;text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">/s/ J</font><font style="font-family:Calibri,sans-serif;font-size:8pt;">EFFREY</font><font style="font-family:Calibri,sans-serif;font-size:10pt;">&#160;J. H</font><font style="font-family:Calibri,sans-serif;font-size:8pt;">ESSEKIEL</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Date</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;font-size:8pt;"><font style="font-family:Calibri,sans-serif;font-size:8pt;font-weight:bold;">Jeffrey J. Hessekiel</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Executive Vice President and General Counsel</font></div></td></tr></table></div></div><div style="line-height:120%;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;"><br></font></div><div><br></div><div><div style="line-height:120%;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></div>	</body>
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<DESCRIPTION>EXHIBIT 99.1
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<div><a name="s43B9165D166C5C5D99DA62604595A47B"></a></div><div><div style="line-height:120%;padding-top:16px;text-align:left;text-indent:48px;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;"><br></font></div><div style="line-height:120%;padding-top:12px;text-align:left;text-indent:666px;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#ff0000;font-weight:bold;">&#160;&#160;&#160;&#160;</font></div></div><div><br></div><div style="line-height:120%;padding-top:12px;text-align:left;text-indent:0px;"><img src="exellogo18q3a02.jpg" alt="exellogo18q3a02.jpg" style="height:60px;width:177px;"></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">Contacts:</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">Chris Senner</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">Chief Financial Officer</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">Exelixis, Inc.</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">650-837-7240</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ba6;font-style:italic;text-decoration:underline;">csenner@exelixis.com</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">Susan Hubbard</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">EVP, Public Affairs &amp; Investor Relations</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">Exelixis, Inc.</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;">650-837-8194</font></div><div style="line-height:120%;padding-top:0px;text-align:right;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ba6;font-style:italic;text-decoration:underline;">shubbard@exelixis.com</font></div><div style="line-height:120%;padding-top:12px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">EXELIXIS </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">ANNOUNCES FIRST QUARTER 2019 FINANCIAL </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">RESULTS AND PROVIDES CORPORATE UPDATE</font></div><div style="line-height:120%;padding-top:12px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">- Total Revenue of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">$215.5</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">&#32;Million, Cabozantinib Franchise Revenue of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">$179.6</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">&#32;Million -</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">- GAAP Diluted EPS of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">$0.24</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">, Non-GAAP Diluted EPS of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">$0.27</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">&#32;-</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-style:italic;font-weight:bold;">- Conference Call and Webcast Today at 5:00 PM Eastern Time -</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">ALAMEDA, CA. - </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May&#160;1, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-style:italic;font-weight:bold;">-</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;Exelixis, Inc. (Nasdaq: EXEL) today reported financial results for the first quarter of 2019 and provided an update on progress toward fulfilling its key corporate objectives, as well as commercial and clinical development milestones.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#8220;The first quarter of 2019 was a very productive start to the year, with strong execution across all aspects of our business,&#8221; said Michael M. Morrissey, Ph.D., President and Chief Executive Officer of Exelixis. &#8220;We continued our efforts to maximize the commercial and clinical potential of cabozantinib through the U.S. launch in advanced hepatocellular cancer in January, as well as the initiation of the COSMIC-313 study announced today.&#8221;</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Dr. Morrissey continued: &#8220;The financial stability provided by our growing revenue base across product and collaboration revenue provides Exelixis with an effective foundation upon which to pursue long-term growth. We have ambitious plans for the rest of 2019: we intend to start additional cabozantinib pivotal trials, bring new assets into our development organization through internal drug discovery and external business development, and advance our early-stage pipeline, including XL092. As we move through our 25</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;"><sup style="vertical-align:top;line-height:120%;font-size:pt">th</sup></font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;anniversary year, not only is our commitment to helping patients with cancer stronger than ever, but our ability to do so is notably stronger as well.&#8221; </font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">First Quarter 2019 Financial Results</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Total revenues </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;were </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$215.5 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$213.7 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Total revenues included net product revenues of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$179.6 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$134.3 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. The increase in net product revenues reflected the continued growth of CABOMETYX&#174; (cabozantinib) in the U.S. for the treatment of patients with advanced renal cell carcinoma (RCC), as well as the U.S. launch of CABOMETYX for the treatment of patients with hepatocellular carcinoma (HCC) who have been previously treated with sorafenib, following its approval by the U.S. Food and Drug Administration (FDA) in January 2019.</font></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">2</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">CABOMETYX net product revenues </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;were</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$175.9 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to $171.6 million for the quarter ended December 31, 2018. CABOMETYX net product revenues</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, as compared to the preceding quarter, were </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">impacted by higher discounts and allowances of $7.2 million, driven by increased uptake in the government payor channel. In addition, as of March 31, 2019, the quantity of CABOMETYX inventory in the U.S. wholesaler distribution channel was approximately $2.3 million lower than it was as of December 31, 2018.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Total revenues for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;also include collaboration revenues of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$35.9 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$79.4 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. The decrease in collaboration revenues was primarily the result of a decrease in revenues from milestones recognized from Exelixis&#8217; collaboration agreements, which was partially offset by increases in royalty revenues on net sales of cabozantinib by Ipsen Pharma SAS (Ipsen) outside of the U.S. and Japan, and development cost reimbursements by Ipsen and Takeda Pharmaceutical Company Ltd. (Takeda).</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Research and development expenses</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;were </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$63.3 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$37.8 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. The increase in research and development expenses was primarily related to increases in clinical trial costs, personnel expenses and stock-based compensation. The increase in clinical trial costs was primarily due to costs associated with the expanding clinical trial program for cabozantinib that now includes four phase 3 pivotal studies (CheckMate 9ER, COSMIC-311, COSMIC-312 and COSMIC-313), as well as the multi-cohort phase 1b study, COSMIC-021. The increases in personnel expenses and stock-based compensation were primarily due to increases in headcount to support Exelixis&#8217; expanded discovery and development efforts. </font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Selling, general and administrative expenses</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;were </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$60.1 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$54.0 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. The increase in selling, general and administrative expenses was primarily related to increases in consulting and outside services, personnel expenses, marketing costs and stock-based compensation. The increases in personnel expenses and stock-based compensation were primarily due to increases in general and administrative headcount to support the company&#8217;s commercial and research and development organizations. The increase in consulting and outside services and marketing expenses was primarily due to i</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">ncreases in marketing activities in support of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">the </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">CABOMETYX </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">launch in HCC</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;and continued support of the product in an increasingly competitive RCC market</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Provision for income taxes </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;was </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$14.9 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;and Exelixis&#8217; effective tax rate was </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">16.4%</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$2.5 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;and </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2.1%</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, respectively, for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. The provision for income taxes relating to Exelixis&#8217; pre-tax income for the </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">three months ended</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;text-decoration:none;">March&#160;31, 2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;was largely offset by a valuation allowance against its net operating loss carryforwards and other deferred tax assets. At December 31, 2018, Exelixis released substantially all of the remaining valuation allowance against Exelixis&#8217; deferred tax assets, after Exelixis determined that it was more likely than not that these deferred tax assets would be realized.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">GAAP net income </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;was </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$75.8 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, or </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.25</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, basic and </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.24</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, diluted, compared to GAAP net income of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$115.9 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, or </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.39</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, basic and </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.37</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, diluted, for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. The decrease in net income was primarily related to the decrease in milestone-related revenues and the increases in research and development expenses, selling, general and administrative expenses and the provision for income taxes; those changes were partially offset by the increases in net product revenues and royalty revenues recognized from Exelixis&#8217; collaboration agreements.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">3</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Non-GAAP net income </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">for the quarter ended </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;was </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$85.5 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, or </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.28</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, basic and </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.27</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, diluted, compared to non-GAAP net income of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$125.0 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, or </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.42</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, basic and </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$0.40</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;per share, diluted, for the comparable period in </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. Non-GAAP net income excludes stock-based compensation and adjusts for the related income tax effect.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Cash and cash equivalents, short- and long-term investments and long-term restricted cash and investments </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">totaled </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$1,019.4 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;at </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, compared to </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$851.6 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;at </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">December&#160;31, 2018</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">Non-GAAP Financial Measures</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">To supplement Exelixis&#8217; financial results presented in accordance with GAAP, Exelixis uses certain non-GAAP financial measures in this press release. In particular, Exelixis presents non-GAAP net income (and the related per share measures), which exclude from GAAP net income (and the related per share measures) stock-based compensation expense and adjust for the related income tax effect of this non-GAAP adjustment. </font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Exelixis believes that the presentation of these non-GAAP financial measures provides useful supplementary information to, and facilitates additional analysis by, investors. In particular, Exelixis believes that each of these non-GAAP financial measures, when considered together with its financial information prepared in accordance with GAAP, can enhance investors&#8217; and analysts&#8217; ability to meaningfully compare Exelixis&#8217; results from period to period, and to identify operating trends in Exelixis&#8217; business. Exelixis has excluded stock-based compensation expense because it is a non-cash expense that may vary significantly from period to period as a result of changes not directly or immediately related to the operational performance for the periods presented. Exelixis also regularly uses these non-GAAP financial measures internally to understand, manage and evaluate its business and to make operating decisions. </font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">These non-GAAP financial measures are in addition to, not a substitute for, or superior to, measures of financial performance prepared in accordance with GAAP. Exelixis encourages investors to carefully consider its results under GAAP, as well as its supplemental non-GAAP financial information and the reconciliation between these presentations, to more fully understand Exelixis&#8217; business. Reconciliations between GAAP and non-GAAP results are presented in the tables of this release.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">2019 Financial Guidance </font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Exelixis is maintaining the following financial guidance for 2019. Cost of goods sold is expected to be between 4% and 5% of net product revenues. Research and development expenses are expected to be between $285 million and $315 million and include non-cash expenses related to stock-based compensation of $20 million. Selling, general and administrative expenses are expected to be between $220 million and $240 million and include non-cash expenses related to stock-based compensation of $35 million. Guidance for the effective tax rate in 2019 is between 21% and 23%.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">Cabozantinib Highlights</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Strong Growth in Cabozantinib Franchise Net Revenues and Royalties.</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;Net product revenues generated by the cabozantinib franchise were&#160;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$179.6 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;during the quarter ended&#160;March 31, 2019, an increase of </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">34%</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;year-over-year. During the first quarter of 2019, CABOMETYX generated&#160;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$175.9 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;in net product revenues and COMETRIQ&#174; (cabozantinib) capsules for the treatment of patients with progressive, metastatic medullary thyroid cancer generated an additional&#160;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">$3.7 million</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;in net product revenues. </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Based upon our partner Ipsen&#8217;s cabozantinib-related revenues in the first quarter of 2019 of approximately $63 million, Exelixis earned $14.0 million in royalty revenues at the 22% royalty rate. CABOMETYX continues to expand its global footprint, where it is currently approved and commercially available in 41 and 28 countries, respectively.</font></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">4</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">FDA Approval of CABOMETYX Tablets for Previously Treated HCC.&#160;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">In&#160;January,&#160;Exelixis&#160;announced the&#160;FDA&#160;approval of CABOMETYX for the treatment of patients with HCC who have been previously treated with sorafenib. The FDA&#8217;s approval of CABOMETYX was based on results from the CELESTIAL phase 3 pivotal trial.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Cabozantinib Data at the 2019&#160;American Society for Clinical Oncology Gastrointestinal Cancers Symposium&#160;(ASCO-GI).</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;In&#160;January, data from clinical trials of cabozantinib were featured in five presentations at ASCO-GI in&#160;San Francisco, including further analyses from the CELESTIAL trial.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Takeda&#8217;s Application to the Japanese Ministry of Health, Labour and Welfare (MHLW) for CABOMETYX as a Treatment for Advanced RCC. </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">In April, Takeda, Exelixis&#8217; partner in cabozantinib&#8217;s development and commercialization in Japan, announced that it applied to the Japanese MHLW for approval to manufacture and sell CABOMETYX as a treatment for unresectable and metastatic RCC in Japan. Per the terms of the exclusive licensing agreement the two companies entered into in 2017, Exelixis will receive a $10.0 million milestone payment as a result of this regulatory filing. Exelixis is eligible for additional development, regulatory and first-sales milestone payments, as well as royalties on sales of cabozantinib in Japan.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Completion of Enrollment in CheckMate 9ER. </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">In April, CheckMate 9ER, the phase 3 pivotal trial evaluating the combination of cabozantinib and nivolumab versus sunitinib in patients with previously untreated advanced or metastatic RCC completed enrollment, including in Japan where the last few patients are in the process of being randomized. </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">CheckMate 9ER is sponsored by </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Bristol-Myers Squibb Company (BMS) and co-funded by Exelixis, and Exelixis&#8217; partners Ipsen and Takeda.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Initiation of COSMIC-313, Phase 3 Pivotal Trial Evaluating the Triplet Combination of Cabozantinib, Nivolumab and Ipilimumab Versus the Combination of Nivolumab and Ipilimumab in Patients with Previously Untreated Advanced Intermediate- or Poor-Risk RCC.</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;Today, Exelixis announced the initiation of COSMIC-313, a multicenter, randomized, double-blinded, controlled phase 3 pivotal trial that aims to enroll approximately 676 patients at 150 sites globally. The primary endpoint of the trial is progression-free survival, and the secondary endpoints are overall survival and objective response rate. COSMIC-313 will be conducted in collaboration with BMS</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">,</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;which is providing nivolumab and ipilimumab for use in this trial</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">Corporate Highlights</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">MINNEBRO&#8482; Receives Regulatory Approval for the Treatment of Hypertension in&#160;Japan.</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;In&#160;January, Exelixis&#8217; partner&#160;Daiichi Sankyo&#160;Company, Limited (Daiichi Sankyo) announced that MINNEBRO&#8482; (esaxerenone) tablets had received approval from the&#160;Japanese MHLW&#160;as a treatment for patients with hypertension. MINNEBRO is a compound identified during the prior research collaboration between&#160;Exelixis&#160;and&#160;Daiichi Sankyo, which the companies entered into in&#160;March 2006, and has been subsequently developed by&#160;Daiichi Sankyo. Per the collaboration agreement,&#160;Exelixis&#160;will receive a&#160;$20.0 million&#160;milestone payment upon the first commercial sale of MINNEBRO in&#160;Japan.&#160;Exelixis&#160;is eligible for additional commercialization milestone payments, as well as low double-digit royalties on sales of MINNEBRO.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">Start of Phase 1 Development for XL092.&#160;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">In February, Exelixis&#160;announced it had submitted an investigational new drug (IND) application to the&#160;FDA&#160;for XL092, a next-generation small molecule tyrosine kinase inhibitor targeting VEGF receptors, MET and other kinases implicated in cancer&#8217;s growth and spread. Following the FDA&#8217;s acceptance of the IND filing, Exelixis initiated a phase 1 dose escalation trial evaluating the pharmacokinetics, safety and tolerability of XL092 in patients with advanced solid tumors, with the primary objective of determining a dose for daily oral administration of XL092 suitable for further evaluation. Assuming positive data from the initial phase of the trial, the expansion phase is designed to further explore the selected dose of XL092 in </font></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">5</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">individual tumor cohorts, where safety, tolerability and initial clinical activity would be evaluated. XL092 is the first clinical candidate to emerge from Exelixis&#8217; in-house laboratories since Exelixis resumed drug discovery activities.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">Basis of Presentation</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Exelixis has adopted a 52- or 53-week fiscal year that generally ends on the Friday closest to December 31</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;"><sup style="vertical-align:top;line-height:120%;font-size:pt">st</sup></font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. For convenience, references in this press release as of and for the fiscal periods ended March 29, 2019, December 28, 2018 and March 30, 2018 are indicated as being as of and for the periods ended March 31, 2019, December 31, 2018 and March 31, 2018, respectively. </font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">Conference Call and Webcast</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Exelixis management will discuss the company&#8217;s financial results for the first quarter of 2019 and provide a general business update during a conference call beginning at 5:00 p.m. EDT / 2:00 p.m. PDT today, Wednesday, May 1, 2019.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">To access the webcast link, log onto </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;font-style:italic;text-decoration:underline;">www.exelixis.com</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;and proceed to the News &amp; Events / Event Calendar page under the Investors &amp; Media heading. Please connect to the company&#8217;s website at least 15 minutes prior to the conference call to ensure adequate time for any software download that may be required to listen to the webcast. Alternatively, please cal</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">l </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;text-decoration:underline;">855-793-2457</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;(domestic) or </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;text-decoration:underline;">631-485-4921</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;(inte</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">rnational) and provide the conference call passcode </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">4774486 </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">to join by phone.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">A telephone replay will be available until 8:00 p.m. EDT on May 3</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, 2019</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. Access numbers for the telephone re</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">play are: </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;text-decoration:underline;">855-859-2056</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;(domestic) and </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;text-decoration:underline;">404-537-3406</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;(inte</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">rnational); the passcode is </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">4774486</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">. A webcast replay will also be archived on </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;font-style:italic;text-decoration:underline;">www.exelixis.com</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;for one year.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">About Exelixis</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">Founded in 1994,&#160;Exelixis, Inc.&#160;(Nasdaq: EXEL) is a commercially successful, oncology-focused biotechnology company that strives to accelerate the discovery, development and commercialization of new medicines for difficult-to-treat cancers. Following early work in model genetic systems, we established a broad drug discovery and development platform that has served as the foundation for our continued efforts to bring new cancer therapies to patients in need. Our discovery efforts have resulted in four approved products, CABOMETYX&#174; </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">(cabozantinib), COMETRIQ</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#174;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#160;(cabozantinib), COTELLIC</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#174; </font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">(cobimetinib) and MINNEBRO</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#8482;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">&#32;(esaxerenone), and we have entered into partnerships with leading pharmaceutical companies to bring these important medicines to patients worldwide. Supported by revenues from our marketed products and collaborations, we are committed to prudently reinvesting in our business to maximize the potential of our pipeline. We are supplementing our existing therapeutic assets with targeted business development activities and internal drug discovery - all to deliver the next generation of&#160;Exelixis&#160;medicines and help patients recover stronger and live longer.&#160;Exelixis&#160;is a member of Standard &amp; Poor&#8217;s (S&amp;P) MidCap 400 index, which measures the performance of profitable mid-sized companies. For more information about&#160;Exelixis, please visit&#160;</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#006ebf;font-style:italic;text-decoration:underline;">www.exelixis.com</font><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">, follow @ExelixisInc on Twitter or like Exelixis, Inc. on Facebook.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;text-decoration:underline;">Forward-Looking Statements</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">This press release contains forward-looking statements, including, without limitation, statements related to: Exelixis&#8217; ambitious plans for the rest of 2019, including Exelixis&#8217; intention to start additional cabozantinib pivotal trials, bring new assets into Exelixis&#8217; development organization through internal drug discovery and external business development, and advance Exelixis&#8217; early-stage pipeline, including XL092; Exelixis&#8217; guidance for 2019 </font></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">6</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">cost of goods sold, research and development expenses (including non-cash expenses related to stock-based compensation), selling, general and administrative expenses (including non-cash expenses related to stock-based compensation), and effective tax rate; Exelixis&#8217; receipt of a $10.0 million milestone payment from Takeda for Takeda&#8217;s submission of an application to the Japanese MHLW for approval to manufacture and sell CABOMETYX as a treatment for unresectable and metastatic RCC in Japan; Exelixis&#8217; eligibility for additional development, regulatory and first-sale milestone payments, as well as royalties on sales under its collaboration with Takeda; the anticipated timing for receipt of a&#160;$20.0 million&#160;milestone payment from&#160;Daiichi Sankyo&#160;upon the first commercial sale of MINNEBRO in&#160;Japan; Exelixis&#8217; eligibility for additional commercialization milestone payments, as well as low double-digit royalties on sales of MINNEBRO; Exelixis&#8217; plans for further explorations of XL092 in the expansion phase of the phase 1 dose escalation trial should data from the initial phase prove positive; and Exelixis&#8217; plans to reinvest in its business to maximize the potential of the company&#8217;s pipeline, including through targeted business development activities and internal drug discovery.&#160;Any statements that refer to expectations, projections or other characterizations of future events or circumstances are forward-looking statements and are based upon Exelixis&#8217; current plans, assumptions, beliefs, expectations, estimates and projections. Forward-looking statements involve risks and uncertainties. Actual results and the timing of events could differ materially from those anticipated in the forward-looking statements as a result of these risks and uncertainties, which include, without limitation: the degree of market acceptance of CABOMETYX, COMETRIQ, COTELLIC and MINNEBRO in the territories where they are approved, and Exelixis&#8217; ability to obtain or maintain coverage and reimbursement for these products; the effectiveness of CABOMETYX, COMETRIQ, COTELLIC and MINNEBRO in comparison to competing products; the level of costs associated with Exelixis&#8217; commercialization, research and development, in-licensing or acquisition of product candidates, and other activities; the potential failure of cabozantinib, cobimetinib, esaxerenone and other&#160;Exelixis&#160;product candidates, both alone and in combination with other therapies, to demonstrate safety and/or efficacy in clinical testing; uncertainties inherent in the drug discovery and product development process; Exelixis&#8217; dependence on its relationships with its collaboration partners, including their pursuit of regulatory approvals for partnered compounds in new indications, their adherence to their obligations under relevant collaboration agreements and the level of their investment in the resources necessary to complete clinical trials or successfully commercialize partnered compounds in the territories where they are approved; risks and uncertainties related to regulatory review and approval processes, including that regulatory authorities may not approve Exelixis&#8217; products as treatments for the indications in which approval has been sought; Exelixis&#8217; continuing compliance with applicable legal and regulatory requirements; unexpected concerns that may arise as a result of the occurrence of adverse safety events or additional data analyses of clinical trials evaluating cabozantinib, cobimetinib or esaxerenone; Exelixis&#8217; dependence on third-party vendors for the manufacture and supply of its products; Exelixis&#8217; ability to protect its intellectual property rights; market competition, including the potential for competitors to obtain approval for generic versions of Exelixis&#8217; marketed products; changes in economic and business conditions; and other factors discussed under the caption &#8220;Risk Factors&#8221; in Exelixis&#8217; Annual Report on Form 10-K filed with the&#160;Securities and Exchange Commission&#160;(SEC) on&#160;February 22, 2019, and in Exelixis&#8217; future filings with the&#160;SEC, including, without limitation, Exelixis&#8217; Quarterly Report on Form 10-Q expected to be filed with the&#160;SEC&#160;on&#160;May 1, 2019. All forward-looking statements in this press release are based on information available to&#160;Exelixis&#160;as of the date of this press release,&#160;and Exelixis&#160;undertakes no obligation to update or revise any forward-looking statements contained herein.</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:174%;padding-top:0px;text-align:center;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-style:italic;">Exelixis, the Exelixis logo, CABOMETYX, COMETRIQ and COTELLIC are registered U.S. trademarks.</font></div><div style="line-height:120%;padding-top:0px;text-align:center;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-style:italic;">MINNEBRO is a Japanese trademark.</font></div><div style="line-height:120%;padding-top:12px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">-see attached financial tables-</font></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><a name="s51745232DDF850ADA6A0265115E80317"></a></div><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">7</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">EXELIXIS, INC.</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">CONDENSED CONSOLIDATED STATEMENTS OF INCOME</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(in thousands, except per share amounts)</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(unaudited)</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:center;font-size:11pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;margin-left:auto;margin-right:auto;width:100%;border-collapse:collapse;text-align:left;"><tr><td colspan="8"></td></tr><tr><td style="width:71%;"></td><td style="width:1%;"></td><td style="width:12%;"></td><td style="width:1%;"></td><td style="width:1%;"></td><td style="width:1%;"></td><td style="width:12%;"></td><td style="width:1%;"></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="7" style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">Three Months Ended March 31,</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">2019</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">2018</font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Revenues:</font></div></td><td colspan="3" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Net product revenues</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">179,581</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">134,272</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Collaboration revenues</font></div></td><td colspan="2" style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">35,906</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">79,447</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:36px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Total revenues</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;border-top:1px solid #000000;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">215,487</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;border-top:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;border-top:1px solid #000000;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">213,719</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;border-top:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Operating expenses:</font></div></td><td colspan="3" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Cost of goods sold</font></div></td><td colspan="2" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">7,501</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">5,639</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Research and development</font></div></td><td colspan="2" style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">63,289</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">37,757</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Selling, general and administrative</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">60,138</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">54,016</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:36px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Total operating expenses</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">130,928</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">97,412</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Income from operations</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">84,559</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">116,307</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Other income (expense), net:</font></div></td><td colspan="3" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td></tr><tr><td style="vertical-align:middle;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Interest income</font></div></td><td colspan="2" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">6,087</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">1,895</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Other, net</font></div></td><td colspan="2" style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">25</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">169</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:36px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Total other income (expense), net</font></div></td><td colspan="2" style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">6,112</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">2,064</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Income before income taxes</font></div></td><td colspan="2" style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">90,671</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">118,371</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Provision for income taxes</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(14,896</font></div></td><td style="vertical-align:middle;border-bottom:1px solid #000000;padding-right:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">)</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(2,514</font></div></td><td style="vertical-align:middle;border-bottom:1px solid #000000;padding-right:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">)</font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:12px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;text-indent:24px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Net income</font></div></td><td style="vertical-align:middle;border-bottom:3px double #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;border-bottom:3px double #000000;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">75,775</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;border-bottom:3px double #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;border-bottom:3px double #000000;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">115,857</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Net income per share, basic </font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.25</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.39</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Net income per share, diluted </font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.24</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.37</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Shares used in computing net income per share, basic </font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">300,542</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">296,421</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Shares used in computing net income per share, diluted</font></div></td><td colspan="2" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">314,644</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">313,691</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr></table></div></div><div><br></div><div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:312px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;">- more -</font></div></div><hr style="page-break-after:always"><div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:left;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">Exelixis First Quarter 2019 Financial Results&#160;&#160;&#160;&#160;Page </font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">8</font><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">&#32;of 8</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:justify;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;font-weight:bold;">May 1, 2019</font></div></div><div><br></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">EXELIXIS, INC.</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">CONDENSED CONSOLIDATED BALANCE SHEET DATA</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(in thousands)</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(unaudited)</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:center;font-size:11pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;margin-left:auto;margin-right:auto;width:100%;border-collapse:collapse;text-align:left;"><tr><td colspan="8"></td></tr><tr><td style="width:73%;"></td><td style="width:1%;"></td><td style="width:11%;"></td><td style="width:1%;"></td><td style="width:1%;"></td><td style="width:1%;"></td><td style="width:11%;"></td><td style="width:1%;"></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">March&#160;31, <br>2019</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:center;text-indent:2px;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">December 31, 2018 </font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;"><sup style="vertical-align:top;line-height:120%;font-size:pt">(1)</sup></font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Cash and investments </font><font style="font-family:Calibri,sans-serif;font-size:11pt;"><sup style="vertical-align:top;line-height:120%;font-size:pt">(2)</sup></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">1,019,369</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">851,621</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Working capital</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">821,166</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">791,544</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Total assets</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">1,541,794</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">1,422,286</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Total stockholders&#8217; equity</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">1,385,020</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">1,287,453</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr></table></div></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:left;padding-left:48px;text-indent:-24px;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">_______________________________________</font></div><table cellpadding="0" cellspacing="0" style="padding-top:0px;padding-bottom:0px;font-family:Times New Roman; font-size:10pt;"><tr><td style="width:48px;"></td><td></td></tr><tr><td style="vertical-align:top"><div style="line-height:120%;font-size:9pt;padding-left:24px;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">&#32;(1)</font></div></td><td style="vertical-align:top;"><div style="line-height:120%;text-align:left;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">Derived from the audited consolidated financial statements.</font></div></td></tr></table><table cellpadding="0" cellspacing="0" style="padding-top:0px;padding-bottom:0px;font-family:Times New Roman; font-size:10pt;"><tr><td style="width:48px;"></td><td></td></tr><tr><td style="vertical-align:top"><div style="line-height:120%;font-size:9pt;padding-left:24px;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">&#32;(2)</font></div></td><td style="vertical-align:top;"><div style="line-height:120%;text-align:left;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">Cash and investments include cash and cash equivalents, short- and long-term investments and long-term restricted cash and investments. Long-term restricted cash and investments totaled </font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">$1.1 million</font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">&#32;as of </font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">March&#160;31, 2019</font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">&#32;and </font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">December&#160;31, 2018</font><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;">.</font></div></td></tr></table><div><a name="sE2C96431F6445D91A11DEED0FA67E598"></a></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;"><br></font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">EXELIXIS, INC.</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;font-weight:bold;">RECONCILIATION OF GAAP NET INCOME TO NON-GAAP NET INCOME </font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(in thousands, except per share amounts)</font></div><div style="line-height:120%;padding-top:0px;text-align:center;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(unaudited)</font></div><div style="line-height:120%;padding-bottom:0px;padding-top:0px;text-align:left;font-size:11pt;"><div style="padding-left:0px;text-indent:0px;line-height:normal;padding-top:10px;"><table cellpadding="0" cellspacing="0" style="font-family:Times New Roman;font-size:10pt;width:100%;border-collapse:collapse;text-align:left;"><tr><td colspan="8"></td></tr><tr><td style="width:71%;"></td><td style="width:1%;"></td><td style="width:12%;"></td><td style="width:1%;"></td><td style="width:1%;"></td><td style="width:1%;"></td><td style="width:12%;"></td><td style="width:1%;"></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="7" style="vertical-align:bottom;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">Three Months Ended March 31,</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">2019</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:middle;border-bottom:1px solid #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;border-top:1px solid #000000;"><div style="text-align:center;font-size:9pt;"><font style="font-family:Calibri,sans-serif;font-size:9pt;color:#000000;font-style:normal;font-weight:bold;text-decoration:none;">2018</font></div></td></tr><tr><td style="vertical-align:middle;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">GAAP net income</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">75,775</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">115,857</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Adjustments:</font></div></td><td colspan="3" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="3" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Stock-based compensation - research and development expenses</font></div></td><td colspan="2" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">4,306</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">3,033</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Stock-based compensation - selling, general and administrative expenses</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">8,223</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">6,272</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:20px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:10pt;"><font style="font-family:Calibri,sans-serif;font-size:10pt;">Income tax effect of the above adjustments</font></div></td><td colspan="2" style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(2,809</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;padding-right:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">)</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">(200</font></div></td><td style="vertical-align:bottom;border-bottom:1px solid #000000;background-color:#cceeff;padding-right:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">)</font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Non-GAAP net income</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">85,495</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">124,962</font></div></td><td style="vertical-align:bottom;border-bottom:3px double #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">GAAP net income per share, basic</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;border-top:3px double #000000;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-top:2px;padding-bottom:2px;border-top:3px double #000000;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.25</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;border-top:3px double #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;border-top:3px double #000000;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-top:2px;padding-bottom:2px;border-top:3px double #000000;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.39</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;border-top:3px double #000000;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">GAAP net income per share, diluted</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.24</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.37</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Non-GAAP net income per share, basic</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.28</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;background-color:#cceeff;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.42</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Non-GAAP net income per share, diluted</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.27</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td style="vertical-align:middle;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">$</font></div></td><td style="vertical-align:middle;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">0.40</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Shares used in computing net income per share, basic </font></div></td><td colspan="2" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">300,542</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;background-color:#cceeff;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">296,421</font></div></td><td style="vertical-align:bottom;background-color:#cceeff;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr><tr><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="text-align:left;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">Shares used in computing net income per share, diluted</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">314,644</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td><td style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;padding-right:2px;"><div style="overflow:hidden;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;">&#160;</font></div></td><td colspan="2" style="vertical-align:bottom;padding-left:2px;padding-top:2px;padding-bottom:2px;"><div style="text-align:right;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;">313,691</font></div></td><td style="vertical-align:bottom;"><div style="text-align:left;font-size:10pt;"><font style="font-family:inherit;font-size:10pt;"><br></font></div></td></tr></table></div></div><div style="line-height:120%;padding-top:12px;text-align:center;padding-left:0px;text-indent:0px;font-size:11pt;"><font style="font-family:Calibri,sans-serif;font-size:11pt;color:#000000;"># # #</font></div><div><br></div>	</body>
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##__9

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
