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Collaboration Agreements (Ipsen Collaboration, Narrative) (Details)
3 Months Ended 12 Months Ended
Jan. 03, 2020
USD ($)
Sep. 27, 2019
USD ($)
Jun. 28, 2019
USD ($)
Mar. 29, 2019
USD ($)
Dec. 28, 2018
USD ($)
Sep. 29, 2018
USD ($)
Jun. 29, 2018
USD ($)
Mar. 31, 2018
USD ($)
Jan. 03, 2020
USD ($)
Jan. 03, 2020
CAD ($)
Dec. 28, 2018
USD ($)
Dec. 29, 2017
USD ($)
Dec. 30, 2016
USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Milestone payments earned $ 15,100,000 $ 50,600,000 $ 20,400,000 $ 10,000,000.0 $ 29,600,000 $ 42,600,000 $ 25,800,000 $ 66,500,000          
Remaining performance obligation 63,100,000               $ 63,100,000        
Collaborative Arrangement with GlaxoSmithKline                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Collaboration agreement percent of royalty on net sale                 3.00% 3.00%      
Collaborative arrangement with Ipsen                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Collaboration period to achieve specified levels of commercial performance                 10 years 10 years      
Upfront payments                         $ 210,000,000.0
Milestone payments earned to date 330,000,000.0               $ 330,000,000.0        
Milestone payments earned                 55,000,000.0   $ 140,000,000.0    
Eligible payment from collaboration for development and regulatory milestone achievement under collaborations agreement 79,000,000.0               79,000,000.0        
Maximum amount eligible for commercial milestones under collaborations agreement 470,400,000               $ 470,400,000        
Research and development arrangement performed for others, reimbursement for costs incurred, percent                 35.00% 35.00%      
Net contract liability 152,800,000       182,900,000       $ 152,800,000   182,900,000 $ 69,800,000  
Remaining performance obligation 45,000,000.0               $ 45,000,000.0        
Collaborative arrangement with Ipsen | Final tier                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Royalty tier                   $ 30,000,000.0      
Collaborative arrangement with Ipsen | Minimum | Final tier                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Percent of royalty on net sale                 22.00% 22.00%      
Collaborative arrangement with Ipsen | Maximum | Final tier                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Percent of royalty on net sale                 26.00% 26.00%      
Collaborative arrangement with Takeda                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Upfront payments                       50,000,000.0  
Milestone payments earned to date 26,000,000.0               $ 26,000,000.0        
Milestone payments earned                 16,000,000.0   10,000,000.0    
Eligible payment from collaboration for development and regulatory milestone achievement under collaborations agreement 10,000,000.0               10,000,000.0        
Maximum amount eligible for commercial milestones under collaborations agreement 155,000,000.0               155,000,000.0        
Net contract liability 24,600,000       $ 18,000,000.0       24,600,000   $ 18,000,000.0 $ 14,800,000  
Remaining performance obligation $ 18,100,000               18,100,000        
Collaborative arrangement with Takeda | Initial                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Royalty tier                 $ 300,000,000.0        
Collaborative arrangement with Takeda | Minimum | Final tier                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Percent of royalty on net sale                 20.00% 20.00%      
Collaborative arrangement with Takeda | Minimum | Initial                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Percent of royalty on net sale                 15.00% 15.00%      
Collaborative arrangement with Takeda | Maximum | Final tier                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Percent of royalty on net sale                 30.00% 30.00%      
Collaborative arrangement with Takeda | Maximum | Initial                          
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]                          
Percent of royalty on net sale                 24.00% 24.00%