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Collaboration Agreements (Takeda Collaboration, Narrative) (Details) - USD ($)	3 Months Ended								12 Months Ended
	Jan. 03, 2020	Sep. 27, 2019	Jun. 28, 2019	Mar. 29, 2019	Dec. 28, 2018	Sep. 29, 2018	Jun. 29, 2018	Mar. 31, 2018	Jan. 03, 2020	Dec. 28, 2018	Dec. 29, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments earned	$ 15,100,000	$ 50,600,000	$ 20,400,000	$ 10,000,000.0	$ 29,600,000	$ 42,600,000	$ 25,800,000	$ 66,500,000
Remaining performance obligation	63,100,000								$ 63,100,000
Collaborative arrangement with Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Sales volume period									6 years
Upfront payments											$ 50,000,000.0
Milestone payments earned to date	26,000,000.0								$ 26,000,000.0
Milestone payments earned									16,000,000.0	$ 10,000,000.0
Eligible payment from collaboration for development and regulatory milestone achievement under collaborations agreement	10,000,000.0								10,000,000.0
Maximum amount eligible for development and regulatory milestones	20,000,000.0								20,000,000.0
Maximum amount eligible for commercial milestones under collaborations agreement	155,000,000.0								155,000,000.0
Net contract liability	24,600,000				$ 18,000,000.0				24,600,000	$ 18,000,000.0	$ 14,800,000
Remaining performance obligation	$ 18,100,000								$ 18,100,000
Collaborative arrangement with Takeda | Global
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Research and development arrangement performed for others, reimbursement for costs incurred, percent									20.00%
Collaborative arrangement with Takeda | Japan
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration period to achieve specified levels of commercial performance									2 years
Research and development arrangement performed for others, reimbursement for costs incurred, percent									100.00%
Collaborative arrangement with Takeda | Initial
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Royalty tier									$ 300,000,000.0
Collaborative arrangement with Takeda | Minimum | Initial
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percent of royalty on net sale									15.00%
Collaborative arrangement with Takeda | Minimum | Final tier
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percent of royalty on net sale									20.00%
Collaborative arrangement with Takeda | Maximum | Initial
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percent of royalty on net sale									24.00%
Collaborative arrangement with Takeda | Maximum | Final tier
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percent of royalty on net sale									30.00%
ASU 2014-09 | Adjustments Due to the Adoption of Topic 606 | EMA Filing Acceptance - HCC | Collaborative arrangement with Takeda
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payments earned								$ 10,000,000.0

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