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Collaboration Agreements (Collaboration Revenues - Genentech) (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Jan. 03, 2020	Sep. 27, 2019	Jun. 28, 2019	Mar. 29, 2019	Dec. 28, 2018	Sep. 29, 2018	Jun. 29, 2018	Mar. 31, 2018	Jan. 03, 2020	Dec. 28, 2018	Dec. 29, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Total revenues	$ 240,310	$ 271,703	$ 240,275	$ 215,487	$ 228,602	$ 225,397	$ 186,108	$ 213,719	$ 967,775	$ 853,826	$ 452,477
Collaborative Arrangement with Genentech | Cotellic
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaborative Arrangement, Income (Loss) From Agreement									4,615	8,084	(2,140)
Total revenues									$ 5,679	$ 5,564	$ 6,398

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Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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-Name Accounting Standards Codification
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