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Collaboration Agreements (Takeda Collaboration, Narrative) (Details) - USD ($) $ in Millions | 3 Months Ended | 12 Months Ended
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Jan. 01, 2021 | Oct. 02, 2020 | Jul. 03, 2020 | Apr. 03, 2020 | Jan. 03, 2020 | Sep. 27, 2019 | Jun. 28, 2019 | Mar. 29, 2019 | Jan. 01, 2021 | Jan. 03, 2020 | Dec. 28, 2018 | Dec. 31, 2017
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments earned to date | $ 350.0 |  |  |  |  |  |  |  | $ 350.0 |  |  |
Milestone payments earned | 29.4 | $ 13.5 | $ 43.5 | $ 0.1 | $ 15.1 | $ 50.6 | $ 20.4 | $ 10.0 |  |  |  |
Remaining performance obligation | 86.1 |  |  |  |  |  |  |  | $ 86.1 |  |  |
Collaborative Arrangement with GlaxoSmithKline |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Collaboration agreement percent of royalty on net sale |  |  |  |  |  |  |  |  | 3.00% |  |  |
Collaborative arrangement with Takeda |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Sales volume period |  |  |  |  |  |  |  |  | 6 years |  |  |
Upfront payments |  |  |  |  |  |  |  |  |  |  |  | $ 50.0
Milestone payments earned to date | 92.0 |  |  |  |  |  |  |  | $ 92.0 |  |  |
Milestone payments earned |  |  |  |  |  |  |  |  | 66.0 | $ 16.0 | $ 10.0 |
Milestone payments, yet to be earned | 15.0 |  |  |  |  |  |  |  | 15.0 |  |  |
Maximum amount eligible for commercial milestones under collaborations agreement | 139.0 |  |  |  |  |  |  |  | 139.0 |  |  |
Remaining performance obligation | $ 44.8 |  |  |  |  |  |  |  | 44.8 |  |  |
Collaborative arrangement with Takeda | Initial |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Royalty tier |  |  |  |  |  |  |  |  | $ 300.0 |  |  |
Collaborative arrangement with Takeda | Initial | Minimum |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  |  |  |  |  | 15.00% |  |  |
Collaborative arrangement with Takeda | Initial | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  |  |  |  |  | 24.00% |  |  |
Collaborative arrangement with Takeda | Final tier | Minimum |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  |  |  |  |  | 20.00% |  |  |
Collaborative arrangement with Takeda | Final tier | Maximum |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Percent of royalty on net sale |  |  |  |  |  |  |  |  | 30.00% |  |  |
Collaborative arrangement with Takeda | Japan |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Research and development arrangement performed for others, reimbursement for costs incurred, percent |  |  |  |  |  |  |  |  | 100.00% |  |  |
Collaboration period to achieve specified levels of commercial performance |  |  |  |  |  |  |  |  | 2 years |  |  |

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